Back issues No.1 - 1995  
  Case Report
  Skin Carcinoma With Neuroendocrine Differentiation
Eric J. Gagne, W. P. Daniel Su, Mark R. Pittekow
Dermatol Sinica 13: 1-12, 1995

A rapidly growing tumor on the face of an 87-year-old woman was excised for histopathologic evaluation. The tumor consisted of a poorly differentiated carcinoma with unusual neuroendocrine differentiation. Focal and prominent immunoreactivity for neuron-specific enolase, synaptophysin, and chromogranin was among the distinctive features. Ultrastructural examination demonstrated neurosecretory granules. Additional morphologic findings included clusters of clear cell differentiation. These finding ..................More
  Diabetic Nephropathy with Kyrle's Disease
Huey-Kuang Huang, Tsong-Liang Lee, Ruey-Yi Lin, Herng-Ming Leu Kwang-Rhong Cheng
Dermatol Sinica 13: 13-22, 1995

We report a case of Kyrle's disease with diabetic nephropathy. A 53-year-old female patient had suffered from multiple pruritic papular skin eruptions over both legs and thighs for 4 months. Physical examination showed multiple discrete brownish 2-8 mm hyperkeratotic papules with central keratotic plugs present over both sides of legs, knees and thighs. Histopathological examination revealed an epidermal invagination filled with parakeratotic column and basophilic debris without demonstratabl ..................More
  Nodular Primary Cutaneous Amyloidosis
Yao-Kun Chiu, Miaw-Shyun Chang Lai, Ji-Chen Ho, Wei-Jen Chen
Dermatol Sinica 13: 23-32, 1995

We herein report a case of primary cutaneous nodular amyloidosis. A 38-year-old man had developed confluent brownish-red, soft, waxy papuloplaques on his left nasolabial fold for 4 months. Histopathology revealed bundles of amorphous, eosinophilic substance occupying the entire dermis with surrounding fibroblasts. Electromicroscopic examination showed long, straight amyloid filaments having close spatial relation with collagen fibrils in the masses.Origin of amyloid fibrils of nodular amyloid ..................More
  Clear Cell Squamous Cell Carcinoma
Chung-Wen Ko, Ching-Nan Lin
Dermatol Sinica 13: 33-39, 1995

A 72-year-old male developed a protruding, round-shaped, smooth, and erythematous nodule on the anterior chest wall of 18 months duration. Histopathological examination revealed lobules of 'clear' tumor cells and focal areas of keratinization; with special stains, these clear cells were negative with PAS and alcian blue staining, and oil red O staining on residual formalin-fixed wet tissue also failed to indicate any lipid deposition in the cytoplasm. Immunohistochemically, the tumor cells mos ..................More
  Tuberous Sclerosis with Renal Angiomyolipoma and Chronic Renal Failure
Mei-Ling Tsai, Yung-Chuan Hsu, Boon-Sang Lee
Dermatol Sinica 13: 41-51, 1995

A 53-year-old female patient, was admitted on account of fever and abdominal pain for 2 days. Physical examination revealed mutiple pinkish to skin-colored, firm papules located on the nose, nasolabial fold and cheeks, and several skin-colored, conical papules around the nails of the fingers and toes were also found. Histopathology of a papule on the nose revealed a picture of angiofibroma. Laboratory data showed anemia, urinary-tract infection and chronic renal falure. Abdominal sonogram and ..................More
  Subungual Melanoma
En-Yuang Liu, Tsai-Yuan Chang, Ming-Chu Liu
Dermatol Sinica 13: 53-59, 1995

A 37 year old male was noted to have nail bed ulcer, onycholysis and a rapid-growing nodule over nail root of left index since 6 months ago. Histopathology study showed the malignant melanocytes occupied the upper dermis and S-100 protein stain showed positive result. Subungual melanoma was a variant of acral -lentiginous melanoma. ..................More
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