Back issues No.4 - 1995  
  Original Study
  Low-dose Cyclosporin A in Psoriasis
Tien-Yi Tzung, J. Yu-Yun Lee
Dermatol Sinica 13: 197-204, 1995

A total of 11 patients with severe psoriasis, including 8 plaque type and 3 erythrodermic type, with a baseline of psoriasis area and severe index (PASI) of at least 15 were treated with low-dose cyclosporin A (CysA) ranging from 3 to 4.5 mg/kg/day for 16 weeks. The treatment was classified as "successful" if the PASI was reduced to 25% or less of the baselinee value or below 8. Six of the patients having<50% reduction of PASI at weeks 6 were regarded as "non-responders" and CysA treatment was d ..................More
  Evaluation of the Result of Surgical Treatment
Kao-Chia Yang
Dermatol Sinica 13: 205-212, 1995

Basal cell carcinoma is a kind of malignant skin tumor. Surgery is one of the methods of treatment, but recurrence of the tumor is a troublesome problem to doctors. During the 10 years between 1981 and 1990 in Changhua Christian Hospital, 45 cases of primary and solitary basal cell carcinoma were noted. After surgical treatment, they had been followed up for about 6 months to 11 years. The surgical methods in our cases include simple closures, local rotation flaps and skin grafts after wide exci ..................More
  Case Report
  Epidermolysis Bullosa Pruriginosa
Yu-Fu Chen, Tee-Ming Tang, Pang-Liang Lee, Chih-Cheng Chang, J. Yu-Yun Lee
Dermatol Sinica 13: 213-222, 1995

We herein report a case with a highly distinctive phenotype of dystrophic epidermolysis bullosa (DEB). A 31-year-old woman who had experienced moderate to severe pruritus for the past 20 years. Blisters, erosions and subesquent striking anastomosing linear raised scars, lichenified or nodular prurigo-like lesions were present mainly on the shins and the extensor of forearms. Her father and a youndger brother have similar but less severe lesions. DEB was confirmed by electron microscopy and immun ..................More
  Congenital Plate-lide Cutaneous Osteoma
Hsiang-Kai Chao, Han-Nan Liu, Chu-Kwan Wong
Dermatol Sinica 13: 223-229, 1995

Cutaneous ossification is a rare disease. Plate-like cutaneous osteoma was first described by Worret and Burgdorf in 1978. We report a typical case of congenital plate-like cutaneous osteoma without Albright's hereditary osteodystrophy. A seven-month-old female infant presents with mutliple hard, plate-like or papular lesions mainly over the limbs, trunk and inguinal area noted for five months. ..................More
  Albrights Hereditary Osteodystrophy
Ya-Ching Chang, Yu-Shung Lee, Heng-Leong Chan, Huei-Shyong Wang
Dermatol Sinica 13: 231-240, 1995

Albright's hereditary osteodystrophy (AHO) is a rare genetic disorder. It is characterized by short stature, obesity, round face, brachydactyly, mental retardation and ectopic calcification. It can occur in patients in which a peripheral resistance to parathyroid hormone can be demonstrated (pseudohypoparathyroidism) or in subjects who do not show abormalities in calcium and phosphate metabolism (pseudo-pseudohypoparathyroidism).We report a case of AHO presenting with hypocalcemic siezures. She ..................More
  Subngual Squamous Cell Carcinoma
Fang-I Huang, Ren-Chun Liao, Hsiu-Chin Chen, Hsin-Yi Su
Dermatol Sinica 13: 241-247, 1995

A 64-year-old man with a history of long-term recurrent paronychia developed one erythematous granulation tissue beneath the nail plate of L't thumb since 2 years ago. Tenderness and partial destruction of the nail plate were noted. Pyogenic granuloma was suspected and a nail bed biopsy was performed. Histopathology revealed well-defferentiated squamous cell carcinoma. X-ray of left thumb was normal. Simple excision by CO2 laser was done. Unfortunately, disarticulation of the distal phalanx was ..................More
  Erythropoietic Protoporphyria
Wei-Ming Wang, Run-Yee Lin, Sheng-Lueng Du
Dermatol Sinica 13: 249-255, 1995

Erythropoietic protoporphyia is an inherited metabolic disorder of heme biosynthesis with its onset during the age of 1-4 years. We report a patient with a late onset of the diagnostic features of clinical, pathological, and biochemical manifestations of erythropoietic protoporphyria, and then discuss the differential diagnosis. ..................More
  von Recklinghausens Disease Associated with Neurofibrosarcoma
Yih-Shun Chen, Yong-Chai Lee, Su-Tzu Huang, Kuo-Chia Yang, Kun-Tu Yeh
Dermatol Sinica 13: 257-263, 1995

This 25-year-old male patient had presented with typical cutaneous features of von Recklinghausen's disease for more than ten years. Rcently, he noted a new skin lesion over left infra-scapular area, which had clinical characteristics of more rapid growth, deeper situation, larger size and harder consistency in comparison with other neurofibromas. Histopathologic examination revealed neurofibrosarcoma with chondroid and osseous metaplasia. Sarcomatous change within a neurofibroma is not common. ..................More
  Bullous Pemphigoid Occurring in Psoriasis
Shao-Yei Liu, Chen-Nai Wang, Heng-Leong Chan, Tseng-tong Kuo
Dermatol Sinica 13: 265-271, 1995

A 47-year-old man with a 21-year history of psoriasis was admitted to Chanf gung Memorial Hospital for an acute bullous eruption. About one month prior to admission, several small tense vesicles on the psoriatic plagues were noted on the trunk, which then rapidly spread to the extensor surfce of limbs. A biopsy specimen for hematoxylin-eosin stain revealed typical histologic findings of psoriasis.A subepidermal blister containing fibrin, leukocytes and eosinophils was also seen. Direct immunoflu ..................More
  Human Immunodeficiency Virus-Associated Eosinophilic Folliculitis
Jiang-Tsun Lin, Hsu-Po Yeh
Dermatol Sinica 13: 273-280, 1995

We report a case of HIV-associated eosinophilic folliculitis. A 47-year-old asymptomatic HIV carrier presented with multiplee, intensely pruritic, skin-colored or erythematous, discrete urticarial papules on the face, neck, upper trunk and proximal portions of upper extremities. Some of them are follicle-corresponding and topped with pustules. Laboratory examinations revealesd peripheral eosinophilia, elevated serum IgE levels and low CD4 counts. Histopathological study showed perifollicular inf ..................More
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