Back issues No.1 - 1996  
  Current Topics in Melanin Pigmentation and its Application to the Management and Pathophysiology of Pigmentary Diseases
Kowichi Jimbow
Dermatol Sinica 14: 1-14, 1996

Mechanisms involved in the biosynthesis of melanin pigments and melanosomes, and their structural organization are not well understood. However, elucidation of the molecular events involved in these processes would be important in understanding the biology and pathophysiology of normal and abnormal melanin pigmentation in the skin. This elucidation would also provide the basis of developing the targeted depigmenting and melanocytotoxic agents of hyperpigmented skin and pigmentary tumors. It also ..................More
  Original Study
  Factor X IIIa and CD34 in the Differential Diagnosis of Dermatofibroma and Dermatofibrosarcoma Protuberans
Hsiu-Chin Chen, Bee-Fan Chen, Jeng-Jer Chen, Hsin-Yi Su
Dermatol Sinica 14: 15-21, 1996

We use anti-Factor XIIIa and anti-CD34 antibodies for the differential diagnosis for dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP). We stained 24 DFs and 24 DFSPs. 21 DFs (87.5%) contained>10% Factor XIIIa reactive tumor cells. In DFSP, most cases (>90%) had no reactive tumor cells. Human progenitor cell antigen (CD34) was found in 22 DFSPs (>90%) that had>10% reactive tumor cells. In DF, the reactivity of most cases for CD34 was negative (75%) , and only 6 cases had<10% positiv ..................More
  Treat Cutaneous Hyperpigmentation with Chemical Peeling
Chun-Min Wang, Heng-Leong Chan
Dermatol Sinica 14: 22-26, 1996

We treated twelve cases of cutaneous hyperpigmentation with chemical peeling. These cases included five cases of melasma, one case of solar lentigines, two cases of periorbital hyperpigmentation, two cases of freckles and two cases of postinflammatory hyperpigmentation. The reagents of treatments included 50% glycolic acid and 18% to 25% trichloroacetic acid. In the melasma group, three patients had excellent results (improvement>75%) two patients got good results (improvement>50%) , the patient ..................More
  Case Report
  Borderline Tuberculoid leprosy with Late Beversal Reaction
Pa-Fan Hsiao, Hsin-Yi Su, Hsiu-Chin Chen, Yu-Hung Wu
Dermatol Sinica 14: 27-31, 1996

We report a case of borderline tuberculoid leprosy with late onset of reversal reaction. A 44-year-old Taiwanese male had an annular anesthetic plaque on his right thigh and was diagnosed as leprosy in 1987. He received antileprosy therapy for one year and skin smear became negative. However, the lesion became erythematous and indurated in March 1994. The skin biopsy specimen revealed typical changes of reversal reaction which was consitent with the results of skin smear and lepromin test. He wa ..................More
  Dystrophic Epidermolysis Bullosa
Chen-Yi Wu, Chian-Chou Chen, Wen-Jen Wang, Chao Huei Chen, William L. Ho
Dermatol Sinica 14: 32-37, 1996

A 3-month-old male baby presented with multiple recurrent tense bullae on the oral and nasal mucosa, trunk and four limbs since birth. The bullae occurred after minor trauma and healed with atrophic scars and milia formation. Nails showed dystrophic change and lost progressively. Cornea examination revealed epitheliopathy. Abnormality of the big toe of right foot was also noted. Skin biopsy showed subepidermal bullae formation. Immunofluorescence staining with antitype IV collagen antibody showe ..................More
  Pseudomonas Septicemia with Ecthyma Gangrenosum and Nodular Cellulitis
Fang-I Huang, Hsiu-Chin Chen, Hsin-Yi Su
Dermatol Sinica 14: 38-41, 1996

Pseudomonas aeruginosa is an important pathogen in immunocompromised patients. Septicemia can be rapidly fatal in infants and requires prompt diagnosis and aggressive treatment. We report a case of pseudomonas septicemia with typical ecthyma gangrenosum and uncommon nodular cellulitis, accompanied by hypogammaglobulinemia. It is recommended to incise and drain the persistent subcutaneous nodules in addition to systemic antibiotic therapy. Fulminant pseudomonas septicemia in previously healthy in ..................More
  Syringocystadenoma Papilliferum and Unusual Basal Cell Neoplasm Arising in Naevus Sebaceus
Wen-Wei Lin, Hao-Chiung Lin, Kit-Ching Wong
Dermatol Sinica 14: 42-46, 1996

Two small nodules with erosion developed in the plaque of nevus sebaceus in the 42 year-old male patient.Histopathological findings included two kinds of skin tumors except typical naevus sebaceus. One of the two neoplasms was consistent with syringocystadenoma papilliferum. The other was composed of numerous basaloid cell islands with areas differentiated toward hair follicles, sebaceous glands and apocrine glands. Unusual benign basal cell neoplasm was the impression. Few similar cases were no ..................More
  Inflammatory Linear Verrucous Epidermal Nevus (ILVEN)
His-Ching Wang, Jui-Lung Shen, Wen-Jen Wang
Dermatol Sinica 14: 47-50, 1996

ILVEN is a rare skin disorder. We report a typical case, consisting of linear verrucous morphology and early age onset. Histopathology reveals a psoriasiform picture, inflammatory elements and alternating areas of parakeratosis with agranulosis and hyperkeratosis with a distinct granular layer. ..................More
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