Back issues No.2 - 1996  
  Original Study
  Annular Elastolytic Granuloma: A Clinicopathologic Study of 15 Cases and a Literature Review
Chin-Yao Eric Wang, Ramon M. Pujol, Hei-Hwa Lee, W. P. Daniel Su
Dermatol Sinica 14: 51-64, 1996

Background: Annular elastolytic granuloma (AEG) is a cutaneous granuloma that can be misdiagnosed as granuloma annulare, necrobiosis lipoidica, sarcoidosis as well as other granulomas.Objective: To determine the clinicopathologic characteristics of annular elastolytic granuloma (AEG), and to discuss the etiopathogenesis and differential diagnosis.Methods: A retrospective clinical and histopathologic study in 15 patients with AEG.Results: The total patients ranged in age from 52 to 79 years (10 m ..................More
  A Double-blind, Randomized, Parallel and Controlled Study to Evaluate Fluticasone Propionate 0.05% Cream Applied Twice Daily in the Treatment of Psoriasis
Heng-Leong Chan, Chung-Li Huang
Dermatol Sinica 14: 65-70, 1996

The safety and efficacy of fluticasone propionate (CutivateTM) cream 0.05% was studied in 50 psoriatic patients. The patients were enrolled in a double blind, randomized, parallel and controlled trial. Patients who met the inclusion criteria were given fluticasone propionate 0.05% or betamethasone valerate 0.1%. Assessment criteria included the clinical signs and symptoms of the target lesion (pruritus, erythema, plaques and scaling), physician's gross assessment of response to therapy, subjecti ..................More
  Comparing the Efficiency of Chemotherapy between Multidrug Therapy and Dapsone Monotherapy in Multibacillary Leprosy
Hsin-Yi Su, Yang-Jyh Lin, Hsiu-Chin Chen
Dermatol Sinica 14: 71-75, 1996

In this study we compared the efficiency of chemotherapy between dapsone monotherapy and multidrug therapy in multibacillary leprosy outpatients.Thirty-four cases received DDS monotherapy and 38 cases received multidrug therapy. The annual mean bacterial index fell within the first three years were 0.94±0.40, 0.69±0.31 and 0.59±0.30 in the DDS group, in the multidrug therapy group they were 1.38±0.52, 0.94±0.54 and 0.86±0.56 respectively. The difference between these two groups were all si ..................More
  Microbiologic Evaluation of Cellulitis
Jia-Sheng Bair, Shao-Yin Ma, Jung-Luh Wang
Dermatol Sinica 14: 76-81, 1996

Thirty-five patients with cellulitis were studied. Clinical manifestation and laboratory data were recorded. Bacteria cultures were performed via five sampling methods: needle aspiration, tissue biopsy, vesicle aspiration, venous blood collection or swab culture from abscess or ulcer. The most common site of lesion was lower limbs (32 cases, 91.4%), especially legs (22 cases, 62.8%). Twenty-three patients were victims of tinea pedis (71.9% of patients with lesions over lower limbs) and seven pat ..................More
  Case Report
  Symmetrical Peripheral Gangrene of Sudden Onset-A Paraneoplastic Syndrome?
Shih-Tsung Hsu, Yu-Yun Lee, Ming-Fei Liu
Dermatol Sinica 14: 82-88, 1996

Symmetrical acral ischemia or gangrene of precipitous onset is rather uncommon and usually is seen in the setting of disseminated intravascular coagulation, sepsis, purpura fulminans, low cardiac output state, collagen vascular disease or antiphospholipid syndrome. Rarely, it may be the presenting manifestation of malignancy or heralds its recurrence or metastasis. We report a 58 year-old man with history of nasopharyngeal carcinoma presented with symmetrical Raynaud's phenomenon of sudden onset ..................More
  Madelungs Disease
Jiunn-Yih Chen, Sheau-Chiou Chao, J. Yu-Yun Lee
Dermatol Sinica 14: 89-94, 1996

Madelung's disease (benign symmetric lipomatosis) is a rare disease of undetermined cause charactrized by symmetric diffuse deposits of adipose tissue around the neck, suboccipital region, proximal extremities, and upper trunk. This disease usually affects middle-aged, non-obese alcoholic men.A 59-year-old man with a history of alcoholism and alcoholic liver disease noticed progressive enlargement of the arms and upper trunk in the past 2 months. Physical examination showed symmetric, diffuse, n ..................More
  Median Raphe Canals of the Genitoperineum
Cheng-Kun Wang, J. Yu-Yun Lee, Hui-Peng Huang
Dermatol Sinica 14: 95-99, 1996

Congenital anomalies of the genitoperineal median raphe are uncommon. They manifest cysts and canals which may occur at any point along the median raphe extending from the glans penis to the anus. Though usually asymptomatic, median raphe canals (MRCs) may become infected by gonococcus or S. aureus resulting in swelling, tenderness and purulent discharge. MRCs are almost always lined by squamous epithelium. We report an unusual case of MRC occurring in a 4-month-old boy. The lining was of the ra ..................More
  Transfusion-Associated Graft-versus-host Disease
Yu-Chang Chan, Yuh-Chiau Chiang, Chi-Cheng Lin, Ren-Feng Lee, Hsu-Po Yeh
Dermatol Sinica 14: 100-106, 1996

Transfusion-associated graft-versus-host disease (TA-GVHD) is a hazardous, often fatal complication to the transfusion of blood components. It often occurs in immunocompromised patients and those who have received blood from related donors. The clinical features of TA-GVHD are characterized by skin rash, diarrhea, hepatic dysfunction and severe bone marrow suppression often during the first two weeks after transfusion. Here we report a case of a full-term female neonate, who developed TA-GVHD af ..................More
  Linear IgA Disease Associated with Pregnancy
Chih-Tsao Chen, Jauh-Jhy Hurng, Tsu-Chyang Chen
Dermatol Sinica 14: 107-112, 1996

A healthy 30-year-old G2P1 female was admitted in the fourth month of pregnancy with pruritic bullous eruption on the back of one month's duration. Skin biopsy showed a subepidermal blister with infiltration of neutrophils and lymphocytes in the surrounding dermal papillae. Direct immunofluorescent study of perilesional skin on the back revealed linear deposition of IgA along the dermo-epidermal junction. Indirect immunofluorescent study detected binding of IgA to the epidermal aspect of 1M NaCl ..................More
  Pachyonychia Congenita
Shao-Yin Ma, Jia-Sheng Bair
Dermatol Sinica 14: 113-117, 1996

Pachyonychia congenita is a rare hereditary disease characterized mainly by nail hypertrophy and dyskeratoses of skin and mucous membrane. We herein report a case of male patient who has had nail dystrophy since childhood. Hyperkeratosis over soles and tiny keratotic papules are noted on dorsal aspect of fingers and toes. Biopsy from plantar lesions revealed marked orthokeratosis, acanthosis, hypergranulosis with coarse keratohyaline granules. ..................More
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