Back issues No.1 - 1999  
  Original Study
  Abnormal Expression of Epidermal Terminal Differentiation and Functional Abnormalities of the Stratum Corneum in Patients with Keratoderma Tylodes Palmaris Progressiva
Ying-Chang Chen, Meng-Ying Hsieh, Chee-Yin Chai, Jui-Chen Tsai, Hamm-Ming Sheu
Dermatol Sinica 17: 1-15, 1999

Keratoderma tylodes palmaris progressiva (KTPP; also termed "housewives" or "dry palmar"dermatitis) is a type of chronic irritant hand dermatitis and is regarded as a response to the repeated effect of soaps, detergents, and washing. Recent studies have provided evidence that use of epicutaneously applied irritants can lead to destruction of the stratum corneum (SC) and changes in keratinocyte differentiation. However, the extent of epidermal terminal differentiation and the function of the st ..................More
  Case Report
  A Pigmentary Disorder Induced by Piper Betel Leaf -A Clinical and Histopathological Survey of 8 Patients-
Yuan-Li Liao, Tseng-Fang Tsai, Cheng-Shiang Shiao, Yuh-Chiau Chiang, Ren-Feng Lee
Dermatol Sinica 17: 16-23, 1999

A special pigmentary disorder gradually became epidemic in Taiwan since April 1997. Reviewing the history of the recorded cases, we found that this pigmentary disorder occurred exclusively after patients used steamed betel leaves to cover the pre-existing hyperpigmented areas. Skin biopsies and a simple questionnaire inquiring symptoms and associated conditions prior to and during the onset of the pigmentary disorder were given to eight patients who visited our clinic in September 1997. All eigh ..................More
  Eosinophilic Fasciitis
Chia-Lin Liu, J. Yu-Yun Lee
Dermatol Sinica 17: 24-30, 1999

Eosinophilic fasciitis is characterized by scleroderma-like skin changes, peripheral eosinophilia, hypergammaglobulinemia and elevated erythrocyte sedimentation rate. The patient typically presents swelling and stiffness of the distal parts of the extremities. The skin changes evolve from pitting edema to dimpling or peau d'orange appearance and later to woody induration. We report a typical case of eosinophilic fasciitis with rapid onset of diffuse induration of all extremities in a 19-year-old ..................More
  Primary Cutaneous Ossification in Albright's Hereditary Osteodystrophy
Chung-Chi Hsiao, Jung-Liang Lee
Dermatol Sinica 17: 31-37, 1999

Primary cutaneous ossification beginning in infancy is quite rare but occurs in several well-described conditions, such as Albright's hereditary osteodystrophy and primary osteoma cutis. Herein, we describe a 2-year-old child with multiple stony-hard papules and plaques on his extremities and abdomen since one month old. A skin biopsy specimen showed heterotopic bone formation within the dermis. On physical examination the child was characterized by obesity, round face and mental retardation. Ra ..................More
  Acquired Smooth Muscle Hamartoma
Jyh-Chen Chang, Run-Yee Lin, Han-Nan Liu, Teh-Lu Chu
Dermatol Sinica 17: 38-42, 1999

A 36-year-old male presented with a painful skin lesion on the dorsal side of the right fourth toe for several months. Histopathologically, there exhibit multiple large, well-demarcated bundles of smooth muscle in the dermis that extend into the subcutaneous tissue. These bundles were positively stained for smooth muscle actin. The clinicopathological features are compatible with acquired smooth muscle hamartoma. ..................More
Tsung-Hsien Shih, Yu-Fu Chen, Chin-Ming Hung
Dermatol Sinica 17: 43-48, 1999

Piebaldism, a rare autosomal dominant disorder of pigmentation, is characterized by congenital amelanotic patches usually on ventral skin. We describe a typical case with amelanotic patches on the forehead, abdominal wall and anterior aspects of the bilateral legs since birth. Many hyperpigmented macules and patches on the trunk and limbs distributing on both normal and hypopigmented skin were also noted. The differences between this case and Waardenberg's syndrome lie in the lack of clinical fe ..................More
  Angioimmunoblastic T Cell Lymphoma
Rurng-Tzung Feng, Yang-Jyh Lin, Hsiu-Chin Chen, Hsin-Yi Su, Ming-Jyh Chang, Fu-Chu Lu
Dermatol Sinica 17: 49-54, 1999

A 22-year-old young male came to our emergency room presenting with high fever and generally itchy skin rash. Physical examination found bilateral neck and inguinal lymphadenopathy and splenomegaly. The skin biopsy specimen showed perivascular mononuclear cell infiltration in the upper dermis. The lymph node biopsy revealed total effacement of normal architecture which was replaced by profuse small blood vessels and mixed cellular infiltrate, including lymphocytes, eosinophils, histiocytes, immu ..................More
  Cutaneous Epithelioid Angiosarcoma
Hui-Wen Tzeng, J. Yu-Yun Lee, M. Ming-Long Hsu, Maw-Chang Sheen
Dermatol Sinica 17: 55-62, 1999

Epithelioid angiosarcoma is an uncommon variant of poorly differentiated angiosarcoma which usually arises in the soft tissue and skin. Lacking obvious vascular differentiation, it is easilymisdiagnosed as carcinoma or malignant melanoma. We report a new case of cutaneous epithelioid angiosarcoma occurring on the face. A 69-year-old man presented with a 4x3cm erythematous juicy plaque on his right cheek of one month's duration. There was no history of local irradiation or surgery. Biopsy of ..................More
  Subcutaneous Sarcoidosis
Han-Chieh Lee, Shih-Tsung Cheng, Hsin-Su Yu
Dermatol Sinica 17: 63-69, 1999

Cutaneous sarcoid is well recognized, but subcutaneous sarcoidosis appears to be rare and usually heralds systemic involvement. We reported here a case of a 43-year-old female who presented with multiple subcutaneous nodules on the extremities and enlarged parotid glands accompanied by severe dry cough and photophobia for about 3 months. Laboratory investigations revealed a high erythrocyte sedimentation rate level and chest radiography showed a prominent bilateral hilar enlargement. A gallium-6 ..................More
  Effective Treatment of Netherton's Syndrome with Glycolic Acid
Chieh-Huei Lin, Chich-Kung Hsu, Tsen-Fang Tsai
Dermatol Sinica 17: 70-77, 1999

Netherton's syndrome is a rare genodermatosis of unknown cause. It consists of the triad of ichthyosiform dermatosis, trichorrhexis invaginata and atopic diathesis. Treatment with a variety of agents has not shown any consistent improvement. We report a case of Netherton's syndrome treated effectively with glycolic acid. A 18-year-old young female presented with numerous pruritic polycyclic and serpiginous erythematous patches with migratory double-edged scales, and fragility of scalp hair, eyeb ..................More
  Pacinian Neurofibroma of the Scalp
Li-Lin Huang, Meng-Tse Wu, Tsong-Liang Lee
Dermatol Sinica 17: 78-81, 1999

Pacinian neurofibroma is an uncommon benign cutaneous neoplasm characterized by the present of pacinian corpuscles-like structures in a myxoid stroma within the lower dermis. Herein we report a case of pacinian neurofibroma found on the left occipital region of the scalp of a 34-year-old male. Histopathological study revealed several round and ovoid corpuscles with pale-staining concentric lamellae, resembling pacinian corpuscles, embedded in a mucoid matrix. Colloidal iron and alcian blue sta ..................More
  Acquired Digital Fibrokeratoma
Chi-Hong Wu, Gwo-Shing Chen, Hsin-Su Yu
Dermatol Sinica 17: 82-86, 1999

Acquired digital fibrokeratoma is an unusual benign tumor of fibrous tissue. It is characterized by a flesh-colored hyperkeratotic, hornlike projection typically with a surrounding collarette of raised skin at the base, and generally does not exceed 1.5 cm in height or diameter. Here, we report a case of 40-year-old female who suffered from one cone-shaped protruding mass with 1 cm x 1 cm x 0.5 cm in size over the plantar side of the left big toe for about 10 months. Histopathology showed hyperk ..................More
  Osteonevus of Nanta
Hsien-Hung Lai, Sey-En Lin, Woan-Ruoh Lee
Dermatol Sinica 17: 87-90, 1999

This paper describes a 25-year-old male with a skin tumor on his right cheek for more than 10 years. An excisional biopsy was done and the histopathology revealed a picture of intradermal nevus with bony metaplasia at the base. There was no evidence of malignant change. Based on the clinical/pathological features and review of literature, "osteonevus of Nanta" turned out to be the most appropriate diagnosis. Since microscopic examination showed many hair fragments in the bony spheres, we believe ..................More
  Thrombosed Capillary Aneurysm
Shuo-Fang Liang, Yu-Fu Chen, Chih-Ming Hung
Dermatol Sinica 17: 91-93, 1999

Not every black, growing lesion is a melanoma. Thrombosed capillary aneurysm is a cutaneous vascular lesion that may resemble melanoma. We report a case of thrombosed capillary aneurysm occuring on the chest wall of a 9-year-old girl. The necessity of distinguishing these tumors from malignant melanoma is emphasized. ..................More
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