Back issues No.3 - 1999  
  Original Study
  Autotransplantation in Segmental Vitiligo by Using Cultured Pure Melanocytes -Analysis of 19 Treated Cases-
Yu-Fu Chen, Pey-Yuh Yang, Chih-Ming Hung, Ming-Ho Huang, Dan-Ning Hu
Dermatol Sinica 17: 193-199, 1999

The application of cultured autologous pure melanocytes in the treatment of vitiligo has been proven valuable in these years. We have modified a procedure to multiply melanocytes from a small specimen of normally pigmented skin taken from the roof of suction blisters. These melanocytes are then planted onto the CO2 laserbrased vitiliginous areas. Nineteen patients with segmental vitiligo were treated .The repigmented portion of the total treated area amounted to 95-100% in 17 patients and 65 to ..................More
  Nodular Melanoma-A Thirteen-Year Clinical Experience-
Yi-Ju Chen, Chun-Ying Wu, Jung-Ta Chen, Jui-Lung Shen
Dermatol Sinica 17: 200-207, 1999

From 1985 to 1998, 65 patients were diagnosed as cutaneous malignant melanoma at Taichung Veterans General Hospital. Fifteen of them were nodular melanoma. We reviewed the medical charts of these patients. The pathological specimens were reviewed independently by another physician. We then analyzed the mean age at onset, sex, tumor thickness, level of invasion, primary tumor location and metastatic sites. Univariate analysis for survival, according to clinical and histologic tumor behaviors, was ..................More
  Case Report
  Sister Mary Joseph's Nodule -A Case Report and Review of the Literature-
Tsu-Man Chiu, Kao-Chia Yang, Chan-Hao Wang, Julia Huei-Mei Chan
Dermatol Sinica 17: 208-214, 1999

A 29-year-old man presented with a rapidly enlarging, 1.6×1.5 cm, firm, reddish, asymptomatic nodule on the umbilicus for 2 weeks. A skin biopsy specimen of the lesion showed mucin-producing adenocarcinoma, and the patient was diagnosed to have metastatic carcinoma of umbilicus: Sister Mary Joseph's nodule. Search for the primary tumor revealed adenocarcinoma of the stomach with peritoneal carcinomatosis. Sister Mary Joseph's nodule is a well-known entity. It is a rare form of cutaneous metasta ..................More
  Primary Cutaneous Large B-Cell Lymphoma of the Leg
Ching-Ya Wang, Hsien-Ching Chiu
Dermatol Sinica 17: 215-219, 1999

A 73-year-old male patient presented with a 2-year history of a symptomless, solid tumor on his left shin. The tumor progressively enlarged along with development of smaller satellite lesions near the main mass. Histopathological examination showed diffuse infiltration of large atypical cells in the dermis consistent with diffuse large cell lymphoma, and immunohistochemical studies revealed that these cells were L26 positive. Serial staging procedures disclosed a suspicious 1 cm-sized lymph node ..................More
  Langerhans Cell Histiocytosis in a Patient with Psoriasis
Chan-Ho Lai, Tseng-Tong Kuo, Lih-Jen Yang, Wen-Rou Wong, Heng-Leong Chan
Dermatol Sinica 17: 220-224, 1999

We report a rare association of Langerhans cell histiocytosis (LCH) with psoriasis vulgaris. A 68-year-old diabetic woman was admitted under the impression of pulmonary miliary tuberculosis. She had two types of skin lesions. One of them was characterized by generalized erythematous to purpuric crusted papules on the trunk and limbs for more than one year. The other type was typical psoriatic lesions present for more than 8 years. Both types of skin lesions were pruritic. A skin biopsy of the fo ..................More
  Cutaneous Extramedullary Plasmacytoma
Chii-Shyan Lai, Kao-Chia Yang
Dermatol Sinica 17: 225-230. 1999

Extramedullary plasmacytoma (EMP) is found in about 70% of multiple myeloma patients, but cutaneous extramedullary plasmacytoma (CEMP) is quite rare. The appearance of CEMP is considered a bad prognostic sign with poor rate of survival. We describe a case of 65-year-old woman with multiple myeloma diagnosed in November 1996. She received chemotherapy and palliative radiotherapy. Unfortunately, 21 months later, scattered firm, violaceous-red, variably sized nodules with 1 to 3 cm in diameter were ..................More
  Myxoid Lipoma with Lipomembranous Change
Chao-Ming Chao, Chin-Yao Wang, Jung-Mao Chou, Teh-Lu Chu
Dermatol Sinica 17: 231-235, 1999

Myxoid lipoma is occasionally seen in lipomatous neoplasms, but it is extremely rare in association with lipomembranous (membranocystic) change. We report a 67-year-old male who had a progressively enlarged nontender mass over the lateral aspect of the left elbow for more than 10 years. The mass was totally resected and showed a histopathologic picture of myxoid lipoma with many foci of lipomembranous change. The pathogenesis is discussed. ..................More
  Rheumatoid Neutrophilic Dermatitis
Chuen-Lin Liu, Hon-Ru Yu, Ming-Tuo Chuan
Dermatol Sinica 17: 236-241, 1999

Rheumatoid neutrophilic dermatitis (RND) is a very rare cutaneous manifestation of rheumatoid arthritis (RA). A 31-year-old woman with severe seropositive RA presented with infiltrated, skin-colored (fixed urticaria-like) and erythematous papules and plaques on her trunk and extremities for more than one month. Histologic examination revealed a dense neutrophilic dermal infiltrate without associated vasculitis. A diagnosis of RND was made, which can be differentiated from other neutrophilic infl ..................More
  Adult T-Cell Leukemia/Lymphoma with Skin Eruption and Mediastinal Involvement
Yuan-Hsin Lo, Yang-Chih Lin, Hsiu-Chin Chen, Hsin-Yi Su, Ming-Chih Chung
Dermatol Sinica 17: 242-247, 1999

We report a case of adult T-cell leukemia/lymphoma (ATLL) with extraordinary mediastinal lymphadenopathy. A 48-year-old woman presented with inguinal and cervical lymphadenopathy,significant weight loss, and subsequent diffuse cutaneous eruption. Laboratory data revealedhypercalcemia, leukocytosis with atypical lymphocytes, multilobulated cells in the peripheral blood, and a positive anti-human T lymphotropic virus type I (HTLV-I) antibody test. The results of the biopsies of the skin and lymph ..................More
  Papular Elastolytic Granuloma-----A Variant or an Early Stage of Annular Elastolytic Granuloma
Guang-Jeng Hong, Yung-Tsai Li, Kao-Chia Yang, Kun-Tu Yeh
Dermatol Sinica 17: 248-253, 1999

Annular elastolytic granuloma (AEG) is a rare form of dermatosis. Although it usually manifests as annular lesions clinically as reported in the literature, papular lesions with coexisting annular lesions have also been mentioned in some reports. We describe a 53-year-old woman who presented with several grouped bean-sized reddish-brown papules on both sides of her neck, which had grown insidiously for 6 months. Histopathologic examination of two lesions revealed typical features of AEG with fib ..................More
  Bullous Systemic Lupus Erythematosus

Dermatol Sinica 17: 254-262, 1999

A 22-year-old female had developed vesiculobullous eruption for more than two months. The lesions were noted over the face, neck, axillae, four extremities and trunk. Histopathological examination of the vesicular lesions showed subepidermal blister formation which contained mononuclear cells, eosinophils, polymorphonuclear neutrophils, and nuclear dusts. In the periphery of the blister, neutrophils was predominantly noted in the dermis. Direct immunofluorescence (DIF) study showed linear deposi ..................More
  Extensive Skin Excision by Tumescent Local Anesthesia in a Patient with Zosteriform Nevus Comedonicus
Yen-Yu Chao, Ren-Yeu Tsai, Heng-Leong Chan
Dermatol Sinica 17: 263-267, 1999

A 26-year-old woman presented with zonal aggregated papulonodules on her right flank since birth. The lesions appeared like giant comedones occupying the entire right T10 dermatome. The skin biopsy specimen revealed dilated follicles with keratin plugs and proliferating epithelial buds. Because of recurrent infection and inflammation, we totally excised the extensive skin lesion under local anesthesia with the aid of tumescent technique. ..................More
  Behcet's Disease with Successful Skin Graft
Yen-Yu Chao, Chih-Tei Chiang, Ming-Huei Cheng, Heng-Leong Chan
Dermatol Sinica 17: 268-272, 1999

Behcet’s disease is an inflammatory disorder involving many organs. Disarrayed immunoregulation was mostly attributed to be the underlying defect. Though pathergy is not specific for Behcet’s disease, the immune mediated tissue destruction might be viewed as the indicator of disease activity. We present a case of Behcet’s disease with predominant pyoderma gangrenosum-like skin lesions. Surgical debridement and split-thickness skin graft were performed successfully while pathergy turned neg ..................More
  Peutz-Jeghers Syndrome
Chao-Ming Chao, Chin-Yao Wang, Teh-Lu Chu, Heng-Chen Chu, Been-Chang Chan
Dermatol Sinica 17: 273-279, 1999

A typical case of Peutz-Jeghers syndrome is reported. A 45-year-old female patient visited our OPD in order to treat her pigmented lower lip. Physical examination showed multiple brown to black hyperpigmented macular lesions on her fingers,lips and buccal mucosa.Gastroenterologic and radiologic examination revealed quite a few gastric polyps, intestinal polyps and colonic polyps. These polyps were proved to be as hamartomatous polyps by histopathologic examination. The results of laboratory test ..................More
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