Back issues No.4 - 1999  
  Introduction to Immune Electron Microscopy -Principles, Methods and Applications in Dermatology-
Wen-Chieh Chen, Martin Schaller, Hans Christian Korting, Elfriede Januschke, Sarolta Karpati, Gerd Plewig
Dermatol Sinica 17: 282-299, 1999

Immune electron microscopy (IEM), first described by SJ Singer in 1959, has been successfully used in 1970s to localize different antigens specific to pemphigus vulgaris and bullous pemphigoid, respectively. Over the past two decades, development of new immunolabels (ultra-small colloidal gold particles smaller than 10 nm in diameter), new embedding materials (LR White, Lowicryl K4M, K11M, etc), and cryoultramicrotomy has made IEM among the most important tools for the study and diagnosis of ski ..................More
  Original Study
  Side Effects of Topical Corticosteroids -II. Withdrawal Dermatitis and Its Management-
Hamm-Ming Sheu, J. Yu-Yun Lee, Jui-Chen Tsai
Dermatol Sinica 17: 300-315, 1999

Dermatitis following withdrawal (withdrawal dermatitis : WD) of prolonged application of potent topical corticosteroids (TCS) is a troublesome problem, and its mechanism remains unknown. In the present work, we monitored the clinical course of WD and evaluated the effects of repeated applications of petrolatum during the disease process. Thirty-nine patients with WD after stopping potent TCS were divided into two groups: group A (18 patients ) treated with weakly potent hydrocortisone ointment t ..................More
  Case Report
Yi-Chun Lin, Shu-Ling Hu, Ming-Tuo Chuan, Hsien-Ching Chiu, Shiu-Feng Huang
Dermatol Sinica 17: 316-321, 1999

Anetoderma is a localized laxity of the skin with herniation or out-pouching resulting from abnormal elastic tissue. We present a typical case of anetoderma which was observed in a 34-year-old male who presented with one-year history of increasing in number of well-circumscribed, normal skin-colored, soft bladder-like pouches over the back and some atrophic patches on bilateral flexor aspect of the forearms. Histopathology revealed focal decrease of elastic fibers in the dermis. ..................More
  Keratotic Scabies Caused by Occlusive Physical Restraints
Pin-Ju Wang, Yu-Hung Wu, Hsin-Yi Su
Dermatol Sinica 17: 322-326, 1999

We report a case of keratotic scabies caused by use of occlusive physical restraints. A 79-year-old female was admitted to our hospital with pneumonia. Her condition deteriorated, requiring long-term artificial ventilation. Because of confusion, restraints were required. One week after occlusive physical restraints were applied, gray scales and thick crusts were found on the left wrist and hand that had been covered by the restraints. Microscopic examination of scrapings from those scales showed ..................More
  Osteogenic Melanoma
Yi-Ying Chen, Jau-Shiuh Chen, Cheng-Hsiang Hsiao
Dermatol Sinica 17: 327-333, 1999

Osteogenic melanoma is a rare variant of malignant melanoma. We report a case of metastasized melanoma with osteoid formation in a 78-year-old man. This patient had palpable left inguinal lymph nodes along with blackish macules over the left sole when he visited our hospital. However, lymph node dissection was not accepted by the patient until six months after the left sole lesion had been widely excised and proved to be malignant melanoma. The histology of the excised left inguinal lymph nodes ..................More
  POEMS Syndrome -A Case with Three-Year Follow-Up-
Yang-Shia Dai, Hsien-Ching Chiu
Dermatol Sinica 17: 334-338, 1999

We report a typical case of POEMS syndrome manifesting progressive weakness and numbness of bilateral lower legs, abnormal level of thyroid stimulating hormone, estrogen and testosterone, hepatosplenomegaly, M-protein and cutaneous changes. Hypertrichosis,hyperpigmentation, and sclerodermoid change of the skin appeared insidiously along with the onset of the neurological symptoms. Cutaneous angiomas were also noted in this patient, which developed abruptly about six months after the onset of the ..................More
  Treatment of a Plantar Wart Using Intralesional Injection of Interferonα-2b
Shih-Hung Lee, Heng-Leong Chan
Dermatol Sinica 17: 339-342, 1999

The treatment of plantar warts is difficult and often frustrating. The existence of multiple treatment modalities reflects the fact that none is uniformly effective or directly antiviral. Interferon has been effective in treating warts. We report a case with recalcitrant plantar wart who received twice-weekly intralesional injection of interferon α-2b. Clinical remission was reached in 5 weeks. We have followed up the patient for 4 months, no recurrence is noted. ..................More
  Infantile Myofibromatosis
Yuan-Li Liao, Hsien-Ching Chiu, June-Tai Wu, Shiu-Fang Huang
Dermatol Sinica 17: 343-349, 1999

A 2-month-old girl had been noted with a pea-sized, dusky red nodule on her right knee and a 2×2 cm sized adherent whitish plaque with superficial telangiectasia on her right shoulder since birth. Later, a 1.5×2.5 cm fixed indurated plaque was found under a salmon patch on the occipital scalp. After thorough physical examination, two additional subcutaneous masses, both around pea-sized, were found on the right temporal scalp and left forearm, respectively. The initial pathologic evaluation of ..................More
  Multiple Familial Trichoepithelioma
Chao-Ming Chao, Chin-Yao Wang, The-Lu Chu
Dermatol Sinica 17: 350-356, 1999

A typical case of multiple familial trichoepithelioma is reported. A 40-year-old male patient presented with multiple, asymptomatic, skin-colored papules and nodules on his face for more than 30 years. All of the biopsy specimens showed the histopathologic features of trichoepithelioma. The main goal of this article is to discuss the related clinicopathologic features, differential diagnosis and available therapeutic regimens for multiple trichoepithelioma. ..................More
  Cobb Syndrome–A Case Early Diagnosed by MRI–
Chieh-Ping Chiang, Wei-Ming Wang, Run-Yu Lin
Dermatol Sinica 17: 357-363, 1999

Cobb syndrome is a rare skin disease that consists of vascular malformation of the spinal cord and cutaneous hemangioma of the corresponding innervated territory. A 20-year-old male presented with segmentally distributed cutaneous angiomatosis over his right T5-T8 dermatomes. No associated neurologic symptoms were noted. Magnetic resonance imaging (MRI) showed enhancing leptomeningeal lesions on the posterior surface of thoracic cord from T6 to T8 levels. The diagnosis of Cobb syndrome was, in t ..................More
  Acute Respiratory Distress Syndrome Complicating Generalized Pustular Psoriasis
Pa-Fan Hsiao, Hsin-Yi Su, Chien-Liang Wu, Hsiu-Chin Chen
Dermatol Sinica 17: 364-369, 1999

Acute respiratory distress syndrome (ARDS) has rarely been reported as a serious complication of generalized pustular psoriasis. Only seven cases have been described in the medical literature and four of these cases were fatal. We describe a 64-year-old woman with generalized pustular psoriasis who later developed ARDS during hospitalization. This patient with a more than 10 year history of psoriasis vulgaris was admitted due to a widespread pustular eruption. She suddenly developed tachypnea an ..................More
  Angioma Serpiginosum
Wen-Jang Liaw, Chin-Yao Wang, Wei-Chin Lu, The-Lu Chu
Dermatol Sinica 17: 370-375, 1999

Angioma serpiginosum is a rare vascular nevoid disorder with a tendency to manifest itself in the form of capillary dilatation and proliferation in the superficial dermis. It is found almost exclusively in females who have grouped serpiginous erythematous punctate lesions usually on the lower limbs or buttocks. Herein, we report a 19-year-old male patient who had groups of serpiginous punctate lesions on the left lower limb, left buttock, anterior chest wall and left upper limb for more than 10 ..................More
  Systemic Lupus Erythematosus Presenting with Unilateral Periorbital Edema, Erythema and Discoid Lupus Erythematosus Lesions
Li-Ting Wei, Chun-Min Wang, Heng-Leong Chan
Dermatol Sinica 17: 376-380, 1999

Cutaneous manifestations of systemic lupus erythematosus (SLE) include butterfly rashes, discoid and vasculitic lesions. Periorbital edema and erythema occur frequently in cases of dermatomyositis but have rarely been noted in patients of SLE. We report an unusual case of SLE with the unilateral eyelid edema, erythema and lesions of discoid lupus erythematosus as the presenting skin manifestations. The eyelid edema and erythema were successfully controlled with hydroxychloroquine. ..................More
  Kimura's Disease
Shang-Wei Lin, Ming-Yuh Lee, Ho-Hsing Chang
Dermatol Sinica 17: 381-387, 1999

Kimura's disease is a rare inflammatory disorder that occurs predominantly in oriental young males. It typically presents as large subcutaneous masses of head and neck region. Kimura's disease has been confused with angiolymphoid hyperplasia with eosinophilia, from which it should be distinguished as a separate entity. We present a 72-year-old male patient who suffered from an asymptomatic subcutaneous swelling in his left preauricular area associated with left submandibular and upper cervical l ..................More
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