Back issues No.2 - 2001  
  Original Study
  Diagnosis of Pemphigus Vulgaris by Immunoblotting of Cultured Human Keratinocyte Cell Extracts
Po-Hung Chen, Chiu-Yueh Chen, Roger Chin-Che Hsu
Dermatol Sinica 19: 93-97, 2001

Pemphigus vulgaris is one of the major autoimmune bullous diseases which include pemphigus vulgaris, bullous pemphigoid, epidermolysis bullosa acquisita, linear IgA dermatosis, and many more new entities. The diagnosis of pemphigus vulgaris depends on clinical, histological and immunological criteria. Immunoblotting is a newly developed technique used to detect the specific antigens of these autoimmune bullous diseases. In this study, we successfully detected the anti-desmogleins autoantibodies ..................More
  Case Report
  Mycosis Fungoides —A Clinicopathologic Study and Early Diagnosis of Patch Lesions—
Chia-Jung Hsiao, J. Yu-Yun Lee
Dermatol Sinica 19: 98-111, 2001

Mycosis fungoides (MF) is uncommonly reported in Taiwan although it might not be rare. Early, patch MF lesions are often difficult to distinguish from various inflammatory lesions histopathologically. We reported the clinicopathologic findings of 18 cases, the largest series to date in Taiwan. All patients presented with patch or plaque lesions with duration of 3 months to 28 years (mean 6.2 years). Six had unusual manifestations, including localized vitiligo-like lesions, diffuse brownish p ..................More
  Sclerosing Perineurioma —A Case Report—
Li-Ting Wei, Hsin-Chun Ho, Heng-Leong Chan
Dermatol Sinica 19: 112-116, 2001

Perinerurioma is a rare tumors with several variants. The composing cells have distinctive immunohistochemical and ultrastructural features of normal perineurial cells. Since Trombetta's first description in 1978, perineurioma had been classified as intraneural (hypertrophic interstitial neuritis) and extraneural (soft tissue perineurioma) variants. In 1997, a new variant, sclerosing perineurioma, was described and was recognized by compact sclerosis, corded and whorled growth pattern and charac ..................More
  Tricholemmal carcinoma —A Case Report—
Ru-Lin Cheng, Jey-Chaur Chung, Gwo-Shing Chen, Kun-Bow Tsai, Hsin-Su Yu
Dermatol Sinica 19: 117-122, 2001

A 83-year-old woman had a 2.5X1.5 cm hyperkeratotic plaque covered with some crusts, and two reddish nodules were noticed near the center of the lesion. This plaque had been noticed over her right cheek for one year. Histopathological examination reveals that tumor cells showed a lobular proliferation in continuity with the epidermis. Tumor nests were mostly composed of large atypical cells with clear cytoplasm containing UEA-I positive, PAS-positive, and PAS-diastase labile materials. Some o ..................More
  Xanthomatosis Secondary to Lymphedema —Report of A Case and Review of the Literature—
Zen-Hwe Wang, Heng-Leong Chan, Tseng-Tong Kuo
Dermatol Sinica 19: 123-126, 2001

A 14-year-old boy of Noonan's syndrome presented with a markedly enlarged right lower extremity and multiple asymptomatic, firm flesh-colored to yellow papules on the foot, ankle, shin and calf of 2 years' duration. A skin biopsy specimen showed a dermal nodule of xanthomatous foamy histiocytes with dilated vessels and neutrophilic infiltrates. Dilated lymphatics were also noted. Relevant laboratory tests were within normal limits (total cholesterol: 170mg/dl, triglyceride: 72mg/dl). One year la ..................More
  Hyperkeratosis Lenticularis Perstans —Report of A Case—
Jen-Chieh Huang, Po-Han Huang, Ji-Chen Ho, Chao-Cheng Huang
Dermatol Sinica 19: 127-132, 2001

We present a 66 year-old man with hyperkeratosis lenticularis perstans (Flegel's disease). The patient had noted multiple reddish-brown hyperkeratotic papules (2-3mm) on the bilateral dorsum of his feet with slow expansion to his lower legs, thighs, forearms and dorsum of his hands for about 30 years ago. Other family members had similar skin lesions. Histologically, orthokeratotic hyperkeratosis with absence of a granular layer was found. Based on the clinical characteristics and histopathologi ..................More
  Primary Cutaneous Lichen Amyloidosus Following Lines of Blaschko
Ya-Yi Chang, Chung-Hsing Chang, Chi-Hong Wu, Hsin-Su Yu
Dermatol Sinica 19: 133-138, 2001

A 57-year-old male presented with a one-year history of multiple pruritic discrete hyperkeratotic papules that first appeared on his bilateral shins and thighs symmetrically. Lesions were arranged in a distinctive linear pattern on his bilateral shins, which appeared to follow Blaschko's lines. Histologically, round eosinophilic globules were found in the upper dermis, which stained positively with Congo red. Electron microscopy revealed 6 to 10 nm wide, linear, nonbranching tubular fibrils loo ..................More
Chin-Ying Chu, Yung-Tsai Li, Kao-Chia Yang, Tsen-Fang Tsai
Dermatol Sinica 19: 139-143, 2001

A 55-year-old man presented with a painless, brown subcutaneous tumor over medial side of his left lower leg for 5 years. Histopathological examination revealed a well-circumscribed dermal lesion of grouped cystic nodules developing from the infundibula of a ruptured follicle. These nodules composed of aggregations of basaloid cells with nuclear uniformity as well as peripheral palisading. The stroma is composed of delicate fibrillary bundles of collagen resembling the perifollicular sheath and ..................More
  Erythema Nodosum Associated with Pulmonary Aspergilloma
Chia-Yi Yang, Hsien-Ching Chiu, Cheng-Hsiang Hsiao, Yung-Chie Lee
Dermatol Sinica 19: 144-149, 2001

Erythema nodosum is a cutaneous reaction pattern consisting of inflammatory, tender, nodular lesions located primarily over the extensor surface of the lower extremities. Many associated diseases have been mentioned. Herein, we report a rare case of pulmonary aspergilloma with the cutaneous manifestation of erythema nodosum in an immunocompetent 63-year-old male. He has suffered from painful nodules on lower legs with afternoon fever for 4 months. The skin biopsy on shin revealed erythema nodosu ..................More
  Cutaneous Lymphadenoma(Adamantinoid Trichoblastoma)—Report of A Case—
Tsung-Hsieh Tsai, Yun-Ho Lin, Woan-Ruoh Lee
Dermatol Sinica 19: 150-154, 2001

Cutaneous Lymphadenoma is an uncommon epithelial neoplasm with a distinctive histological feature composed of basaloid epithelial proliferation and intraepithelial lymphocytes. The biphasic pattern of epithelial and lymphoid cells is the hallmark of the tumor. It seems to represent a benign adnexal neoplasm of uncertain histogenesis, both of pilosebaceous and eccrine origin have been suggested. We herein report a typical case of cutaneous lymphadenoma that has developed on the right cheek of a 4 ..................More
  Keratotic Scabies of the Scalp Area in a Patient with Dermatomyositis
Chia-Chi Shih, Gwo-Shing Chen, Shih-Tsung Cheng, , Roger Chin-Che Hsu
Dermatol Sinica 19: 155-160, 2001

Massive infestation of Sarcoptes mites is rarely observed, especially in the scalp area. We present a case of dermatomyositis with keratotic scabies in the scalp. Seborrheic dermatitis and flare-up of dermatomyositis were impressed initially. It was not until a scalp scraping showed numerous Sarcoptes mites and ova that the diagnosis of keratotic scabies was finally made. Examination of remaining parts of the body, including interdigital webs, axilla and periumbilical area, revealed no signs of ..................More
  Benign Fibrous Histiocytoma Combined with Leiomyoma—A Case Report & Literature Review—
Cheng-Lun Hsiao, Su-Ying Wen
Dermatol Sinica 19: 161-168, 2001

A 61-year-old female had an elastic, brownish, dome-shaped nodule, 1cm in diameter, over right buttock. It was clinically diagnosed as benign fibrous histiocytoma. Total excision was performed. Histopathologically, the lesion was located in dermis and composed of two different portions. The superficial portion showed irregular border without capsule and composed of slender spindle cells scattered within interlacing fascicles of collagen fibers. The deeper portion adhered to the superficial porti ..................More
  Vestibular Papillomatosis—A Report of Five Cases—
Yuh-Ru Huang, J. Yu-Yun Lee
Dermatol Sinica 19: 169-174, 2001

Vestibular papillomatosis (VP), also known as vestibular papillae, is an anatomical variant of the vestibular mucosa. Clinically VP is characterized by monomorphous, soft tubular papillae in clusters or in linear pattern, distributing symmetrically on inner aspects of the labia minora, hymen or periurethral area. The prevalence rate has been reported to be 1% or higher in British Obs & Gyn studies. Patients with VP apparently are more commonly seen by Obs & Gyn specialists than by dermatologists ..................More
  Pigmented Pilomatricoma
Chih-Hung Lee, Gwo-Shing Chen, Hsin-Su Yu
Dermatol Sinica 19: 175-179, 2001

Pilomatricomas are derived from follicular matrix keratinocytes. Melanin pigments and melanocytes were infrequently noted in these tumours. We brought out a case of pigmented pilomatricoma in the left forearm of a 25-year-old woman. It suggested that the production of hair is the result of coordinated interaction of melanocytes, matrical keratinocytes, and follicular papillae cells. The pigmented variant of pilomatricoma should be considered in the differential diagnosis of pigmented lesions. ..................More
  Resident Forum
  Patchy Hair Loss in a 50-year-old Female
Hsuan-Hsiang Chen, Tsen-Fang Tsai
Dermatol Sinica 19: 180-181, 2001

Case report: A 50-year-old female patient had a 6-month history of patchy hair loss in the scalp. The patient denied any other previous skin disorders. Cutaneous finding showed perifollicular erythema and acuminate keratotic plugs at the margin of the alopecia. The axillae and the public region were not affected. Other physical examination showed whitish reticulated plaques over bilateral mouth angles. An incisional biopsy from the scalp was stained with hematoxyline-eosin and direct immuno ..................More
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