Back issues No.2 - 2004  
  Original Study
  The Expression of Dihydrodiol Dehydrogenase in Squamous Cell Carcinoma of the Skin
Hsin-Yi Lin, Kuan-Chih Chow , Tzei-Yi Lin , Yung-Tin Chang , Hsu-Jung Hsieh , Chien-Jen Huang
Dermatol Sinica 22 : 108-113, 2004

Squamous cell carcinoma(SCC) is one of the most common skin cancers and has many etiologic factors. Polycyclic aromatic hydrocarbons(PAHs) are one of the causes accounting for SCC. How PAHs react to human skin remains unclear. It is known that dihydrodiol dehydrogenase(DDH) is the major enzyme catabolising PAHs. Therefore, we addressed a question on the level of DDH expression in SCC. In this study, eleven cases of SCC were investigated immunohistochemically by DDH-specific polyclonal antibodies ..................More
  Cutaneous Rosai-Dorfman Disease-A Review of 17 Cases
Ching-I Lu, Wen-Ron Wong, Hong-Shang Hong
Dermatol Sinica 22 : 114-123, 2004

Cutaneous Rosai-Dorfman disease(RDD) is a rare entity of unknown etiology. In Taiwan, only scattered cases had been reported. In this retrospective study, we review all patients with pathology-proven RDD diagnosed at Chang-Gung Memorial Hospital from 1995 to 2002, and report the demography, clinical manifestations, pathological characteristics, treatment modalities and prognosis of this entity. The presented series consists of 17 patients of cutaneous RDD, including ten female and seven males, ..................More
  Case Report
  Treatment of Ear Keloid with Enucleation Report of A Case and Review of the Literature
Chih-Sheng Lai, Hung-Wen Kuo, Po-Han Huang
Dermatol Sinica 22 : 124-128, 2004

Treatment of ear keloid is still a challenging problem. There is no consensus in treating keloid scars of the ear. Different treatment strategies have met various recurrence rate and side effects. Excision alone has been proven with high recurrence rate and possible larger keloidal formation. However, newly designed surgical technique may achieve better result. Herein we presented a case of ear keloid treated with a modified surgical technique called "enucleation" and used keloid skin as local f ..................More
  Erythema Nodosum Associated with Active Cytomegalovirus Infection
Hsin-Chieh Tang, Jia-Tsun Yen, Chia-Chun Kao
Dermatol Sinica 22 : 129-133, 2004

Erythema nodosum is associated with a wide variety of diseases, and searching for the underlying etiology is important for management of the disease. Most adults have already been infected by cytomegalovirus(CMV), often subclinically and asymptomatically. Immunocompetent individuals very rarely present with cutaneous manifestations of CMV infection. We report a rare case of erythema nodosum associated with active CMV infection. A 40-year-old female presented with several tender nodules over the ..................More
  Effective Removal of Urchin Spines with Erbium:YAG Laser Ablation:Report of a Case
Chun-Ping Wu , Tsen-Fang Tsai
Dermatol Sinica 22 : 134-137, 2004

In recent years, with the growing popularity of nautical sports, marine medicine becomes increasingly important. The most commonly associated cutaneous diseases are the sun burn and the tanning. The other aquatic dermatology includes water-induced pruritus, pain, eruptions, and contact dermatitis. Injuries by jellyfish stings, venomous fish, sponges, and coral are not uncommon. However, sea urchin sting is relatively rare, and the therapy is often difficult. We report a case of seaurchin-sting s ..................More
  Pseudoxanthoma Elasticum:Report of a Rare Granulomatous Variant
Jennifer C. Lee , Chih-Hsun Yang , Su-Chin Shen , Hong-Shang Hong
Dermatol Sinica 22 : 138-141, 2004

Pseudoxanthoma elasticum(PXE) is an inherited disorder of the connective tissue characterized by degeneration and calcification of elastic fibers in the skin and arterial walls of ocular, cardiovascular, and gastrointestinal systems. This granulomatous variant has seldom been investigated. This article describes a middle-aged male exhibiting typical PXE cobblestone-like changes on his neck skin. A skin biopsy specimen revealed, in addition to the pathognomonic finding of basophilic clumped elast ..................More
  The Combination of Tripe Palms, Acanthosis Nigricans and Florid Cutaneous Papillomatosis in a Patient with Metastatic Cervical Cancer
Yu-Ju Tsai , Yi-Jeng Tsai , Ming-Tuo Chuan , Shu-Ling Hu
Dermatol Sinica 22 : 142-147, 2004

Tripe palms, which described the thickening of pamar skin with increase of normal dermatoglyphics and a peculiar velvety texture, is a specific cutaneous paraneoplastic syndrome especially related to cancers of upper aerodigestive tract. Acanthosis nigricans, and florid cutaneous papillomatosis(sudden appearance of many warty skin lesions) are the most commonly associated paraneoplastic dermatosis. All three may be part of a continuum, caused by factors produced by the underlying malignancy. A t ..................More
  Chronic Radiodermatitis Following Percutaneous Coronary Interventions
Jung-Yi Chan , Chia-Yu Chu
Dermatol Sinica 22 : 148-152, 2004

The incidence of radiodermatitis after percutaneous coronary interventions is rising with the increasing number and complexity of these procedures. This is a case report of a male patient with 3-vessel coronary artery disease in whom chronic radiodermatitis developed following four difficult and prolonged coronary interventions. The skin eruption was characterized by a well-demarcated, atrophic, rectangular plaque presenting as mottled hyper-and hypopigmentation with telangiectasia. Generally, t ..................More
  Microcystic Adnexal Carcinoma of the Nipple
Chien-Hui Hong, Ming-Feng Hou, Gwo-Shing Chen
Dermatol Sinica 22 : 153-158, 2004

A 36-year-old woman came to our OPD with presentation of a solitary, indurated, nonpainful subcutaneous plaque on the left nipple area for 2 months. There was neither discharge nor ulceration. Axillary’s lymph node was not palpable. Histopathological examination directed the diagnosis to microcystic adnexal carcinoma. A wide excision was performed with negative margin. The preoperative and intraoperatove investigations of sentinel lymph node in axilla was not involved. No recurrence was notice ..................More
  Clinical Features and One-year Experience with Enzyme Replacement Therapy in a Taiwanese Kindred with Fabry Disease
Kuan-Hsing Wu , Tien-Yi Tzung , Long-Sun R1 , Kwang-Jen Hsiao
Dermatol Sinica 22 : 159-165, 2004

Fabry disease is an X-linked recessive inheritance with defective activity of lysosomal enzyme, a-galactosidase A. Clinical diagnosis is sometimes difficult because of diverse manifestations. Confirmation of the disease is based on enzyme levels as well as on molecular biology. The prognosis is related to renal, cardiovascular and neurological complications. We report a family with Fabry disease, mother and her two sons(aged 25 and 22 years old, respectively). Both sons had numerous angiokeratom ..................More
  Linear Lupus Erythematosus Profundus on the Scalp Following the Lines of Blaschko in an Adult
Chun-Ping Wu , Tsen-Fang Tsai
Dermatol Sinica 22 : 166-172, 2004

The lines of Blaschko describe distribution patterns which may represent embryologic development pathways. The distribution may be followed by some congenital and acquired skin disorders. Lupus erythematosus profundus(LEP) is a rare disease characterized by deep nodules and plaques, most commonly localized on the buttocks, arms, thighs and face. There is only one reported case of LEP on the scalp following the lines of Blaschko. We herein report the second case. The patient was a 21-year-old fem ..................More
  Lupus Erythematosus-like Skin Lesions Induced by Tegafur-Uracil -A Case Report
Kai-Kuo Lee Sheau-Chiou Chao J.Yu-Yun Lee
Dermatol Sinica 22 : 173-177, 2004

Tegafur-Uracil(UFUR) is a second generation anticancer agent. Few skin lesions are associated with UFUR therapy. Skin lesions with features of lupus erythematosus occurred in a 69-year-old man after starting UFUR treatment for 2 weeks for gastric adenocarcinoma. The diagnosis of drug-induced lupus erythematosus was supported by classic histopathologic findings of cutaneous lupus erythematosus, positive antinuclear(speckled and nucleolar pattern), and anti-SSA/Ro and SSB/La antibodies. The skin l ..................More
  Familial Atrophia Maculosa Varioliformis Cutis-Case Report
Chung-Chu Wang , Pei-Lun Sun , Yu-Hung Wu, Yang-Chih Lin
Dermatol Sinica 22 : 178-182, 2004

Atrophia maculosa varioliformis cutis was first described by Heidingsfeld in 1918 as the gradual, spontaneous appearance of painless, shallow, sharply demarcated depressions of various shapes on the face. To the best of our knowledge, only 17 additional cases have been reported since the first description. We describe the first two patients in Taiwan. They are a sister and brother, aged 10 and 8 years, with multiple, spontaneous, randomly scattered, asymptomatic, atrophic lesions on the cheeks a ..................More
  Ectopic Nail-Report of a Case and Review of the Literature
Chia-Hui Hung , Hung-Wen Kuo , Tzu-Jen Kuo , Po-Han Huang , Ji-Chen Ho
Dermatol Sinica 22 : 183-186, 2004

Ectopic nail is a rare disorder of nail organs, which can be divided into congenital and acquired type. The cases of acquired type are more rare than that of congenital type and frequently caused by inoculation of nail matrix by injury or trauma. The structure of the ectopic nail is similar to the ordinary nail, but it usually grows vertically. There are conflicting opinions concerning why the normal nail grows outward instead of upward. Herein we reported a 67-year-old man with a vertically gro ..................More
  Severe Generalized Pustular Psoriasis Provoked by Oral Terbinafine
Jeng-Wei Tjiu , Tsen-Fang Tsai , Chia-Yu Chu
Dermatol Sinica 22 : 187-192, 2004

Terbinafine is an allylamine antifungal agent. Its severe cutaneous adverse effects are rare, but toxic epidermal necrolysis, pustular drug eruption, acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and erythema multiforme had been reported. Terbinafine was also reported to induce flare-up of chronic psoriasis or development of pustular psoriasis. Here we report a psoriatic patient who developed pustular eruptions in four weeks after treatment with terbinafine for his presum ..................More
  Resident Forum
  A Mildly Indurated, Violaceous Plaque on the Nose in a 78 Year Old Man
Wu-Hui Chang , Kuan-Cheng Hung , Kao-Chia Yang , Mei-Ling Chen , Tsen-Fang Tsa
Dermatol Sinica 22 : 193-194, 2004

Case Report A 78 year old male without prior history of illness presented initially with a mildly indurated plaque on the nose tip of 2-3 months’ duration. The erythematous plaque was irregularly shaped, and had ill defined margins. Satellite erythematous papules were present surrounding the plaque. Progressive enlargement had been noted for 2-3 months (Fig. 1).Palpation did not cause blanching of the plaque. Other areas of the face revealed telangiectasia and evidence of photoaging. No neck ..................More
  A Long Wavy Superficial Burrow on the Foot
Mei-Chin Ho , Ming-Tuo Chuan , Shu-Ling Hu
Dermatol Sinica 22 : 195-196, 2004

Case report: A 2-year-old boy presented with a rapid moving, S-shaped liner red lesion on the lateral side of his left foot for one week 9Fig.1). No specific symptoms were noted. There was no preceding trauma or surgical wound. There was no traveling history recently. The boy lived in Taipei city. On examining his feet, we found an about 3 cm long wavy superficial burrow on the lateral aspect of the left foot. At its lower end, there was a thin dark material 1 cm in length. According to the stat ..................More
  A Painful Furuncle-like Nodule on the Scalp
Fu-Sen Hsieh , J Yu-Yun Lee , Hui-peng Huang
Dermatol Sinica 22 : 197-198, 2004

Case report A 40-year-old healthy male physician presented with a painful erythematous swollen nodule on the scalp for a two-week’s duration after returning from a trip to Peru. He didn’t recall any insect bite during the trip. Approximately one week after returning home he noticed a small papule with intermittent episodes of pain on the scalp. He thought that the lesion might be a folliculitis and topical antibiotic was applied. However, the lesion didn’t improve and progressed to a ..................More
  A Patient of Esophageal Carcinoma Presenting with Fever and Multiple Nodules on Fingers
Yen-Chi Chou , Jing-Yi Lin , Hua-Hsin Chen , Hsin-Chun Ho
Dermatol Sinica 22 : 199-200, 2004

Case report A 63-year-old man experienced progressive dyspnea of 1-week duration in August 2002. Esophageal squamous cell carcinoma with periesophageal soft tissue invasion had been diagnosed 1 year previously. He had been treated with tumor resection and 3 courses of chemotherapy. Two-dimensional cardiac echography showed large amount of pericardial effusion and a vegetation in the left atrium (Fig.1). After performing pericardiocentesis and sclerosing therapy with mitomycin, his symptoms impr ..................More
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