Back issues No.1 - 2005  
  Involvement of Stem Cells in Hair Cycle, Epidermal Homeostasis, and Skin Tumor Formation
Chung Hsing Chang
Dermatol Sinica 23:12-16,2005

Introduction The skin is the largest organ in the body. It consists of epidermis derived from ectoderm, and dermis derived from mesoderm. Hair follicle is an ectodermal organ formed by an intimate interaction between ectoderm and mesoderm. The epidermis is constantly renewed throughout life. Its turnover is estimated at about 60 days in humans. Hairs undergo periods of growth (anagen), destruction (catagen), and rest (telogen), and initiate a new round of follicle growth without ending. Bo ..................More
  Original Study
  Clinical Analysis of Pemphigus Vulgaris and Pemphigus Foliaceus: A Review of 58 Cases
Ting-Yuan Su, Ming-Wei Lin, Yung-Ting Chang, Han-Nan Liu
Dermatol Sinica 23:1-11,2005

Pemphigus is a potentially fatal disease if it becomes refractory to treatment modalities. We sought to evaluate the factors that might affect the prognosis of Pemphigus vulgaris(PV) and Pemphigus foliaceus (PF) and compare the clinical differences between them. We herein studied 58 patients with pemphigus (32 with PV; 26 with PF) who received biopsies and treatments from 1979 to 2002 in the Taipei Veteran General Hospital . Fifteen patients (9 PV and 6 PF patients, 25.9%) expired in the study. ..................More
  Case Report
  Type I cryoglobulinemia and multiple myeloma presenting with widespread livedo reticularis and skin necrosis
Chao-Chun Yang, Tzu-Kai Lin, Julia Yu-Yun Lee
Dermatol Sinica 23:17-20,2005

Abstract Cryoglobulins are reversibly cold-precipitating, circulating immunoglobulins which can lead to clinical symptoms, such as recurrent palpable purpura, polyarthralgia and renal disease. A 65-year-old Taiwanese man presented with widespread, severe livedo reticularis of all four extremities with acrocyanosis, Raynaud’s phenomenon, and eventuated in necrosis of auricular helices, scrotum and fingers after repeated cold exposure. Biopsy of livedo reticularis revealed dermal thrombosis wit ..................More
  Candidal Granuloma: A Case Report
Hung-Jin Shih, Shiow-Jiuan Wey, Tsai-Wen Wu, Keh-Liang Lin, en-Hung Yang
Dermatol Sinica 23:21-26,2005

Candidal granuloma is rare manifestation of mucocutaeous candidiasis. We herein reported an unusual case of candidal granuloma caused by Candida albicans. An ulcerated plaque with crusts on the left upper limb developed in a 75-year-old female with diabetes mellitus and liver cirrhosis. Candidal granuloma was diagnosed according to yeast biochemistry test, tissue culture and histopathology. ..................More
  Tuberculous gumma(Cutaneous metastatic tuberculous abscess)
Mei-ju Ko, Chia-cheng Wu, Hsien-Ching Chiu
Dermatol Sinica 23:27-31,2005

Abstract Tuberculous gumma, also called metastatic tuberculous abscess, is a multibacillary type of skin tuberculosis caused by hematogenous spread of mycobacteria from a primary focus. We report a patient with tuberculous gumma on the right shin. The 68-year-old woman with pulmonary miliary tuberculosis and an occult non-Hodgkin lymphoma was found to have a pigeon-egg sized, soft nodule on the right shin. Histopathologic examination showed granulomatous inflammation with occasional giant cells ..................More
  A Novel Mutation in the L12 Domain of keratin 5 in the Kobner Variant of Epidermolysis Bullosa Simplex
Shao-Min Hsu, Julia Yu-Yun Lee, Mei-Hui Yang, Sheau-Chiou Chao
Dermatol Sinica 23:32-35,2005

Abstract Epidermolysis bullosa simplex (EBS) is a group of hereditary bullous diseases, characterized by intraepidermal blistering due to mechanical stress-induced degeneration of basal keratinocytes. Three major subtypes have been identified with autosomal dominant inheritance: Weber-Cockayne type, Kobner type (EBS-K), and Dowling-Meara type. These three EBS subtypes are all caused by mutations in either keratin 5 gene or keratin 14 gene, the major keratins expressed in the basal layer of the ..................More
  Localized chrysiasis induced by laser in a patient with rheumatoid arthritis
Yu-Ting Huang, Ren-Yu Tsai, Wei-Yu Chen, Woan-Ruoh Lee, Kuo-Hsien Wang
Dermatol Sinica 23:36-40,2005

Abstract Chrysiasis is an uncommon permanent blue-gray discoloration occurring on the sun-exposed skin of the patients who have been exposed to gold salts. Light exposure and total amount of gold administrated have been reported to play important roles in the development of chrysiasis. We herein report a case of localized chrysiasis in a patient with rheumatoid arthritis who had received long-term parenteral chrysotherapy. Blue-gray discoloration has developed after laser treatment for her frec ..................More
  Haberland syndrome
Chih-Chieh Chan, Jau-Shiuh Chen, Chia-yu Chu
Dermatol Sinica 23:41-45,2005

ABSTRACT Haberland syndrome, also known as encephalocraniocutaneous lipomatosis (ECCL) is a very rare congenital disorder which has been reported for only 36 cases worldwide since its first description. The syndrome is characterized by several specific clinical findings in different organ systems which can be presented within a spectrum. In our case, the exact diagnosis of ECCL was delayed for 25 years since his birth. We reported this rare case and reviewed related literature. ..................More
  Resident Forum
  Numerous Verrucous Brownish Papules over the Back in a 27-year-old Man
Chih-Sheng Lai, Hung-Wen Kuo, Po-Han Huang
Dermatol Sinica 23:46-47,2005

CASE REPORT A 27-year-old male presented with a 5-year history of velvous brownish lesions on his entire back. The brownish papules initially appeared on the central region of the back with subsequent peripheral extension. Mild itch was noted especially after taking a shower. Skin examination revealed numerous verrucous brownish papules arranged in a specific pattern, which were confluent in the center and reticulated at the periphery (Fig. 1). Skin scrapings for potassium hydroxide examinati ..................More
  Generalized Vesicles and Erythematous Papules with Bullae on Bilateral Ankles in a 6-year-old Boy
Hsin Huang , Tzei-Yi Lin, Chau-Hong Liu, Shu-Rung Shei
Dermatol Sinica 23:48-49,2005

CASE REPORT A 14-year-old boy with nonspecific family history presented with several pink to red papules on his right nose and cheek for 2 years. The facial lesions appeared initially on the nasal ala as small, flesh-to-pink-colored, and mildly protruding pimples. He was brought to several dermatological clinics with the impression of acne vulgaris in the past 2 years. Some papules got improved months later, but some got worse with an intensified color when exercising. These "non-resolving acne ..................More
  Erythroderma with Scaling Patches
Hsin Huang , Shu-Rung Shei , Kao-Sung TsiTzei-Yi Lin* , Chen-Jen Huang, Chau-Hong Liu
Dermatol Sinica 23:50-51,2005

CASE REPORT 一個6歲大男童呈現雙側踝部皮膚大小水泡及全身性紅色丘疹變化已有2年。2年前疾病之原始呈現為全身性小水泡及丘疹,數週後膝部以下出現大水泡。整個病情時好時壞,好的時候只出現全身性小水泡及丘疹,不會癢亦不會疼痛,壞的時候則除了小水泡及丘疹外,還於足踝出現較大水泡且伴有疼痛。病灶集中在小腿下半部。2年來一直被診斷為昆蟲咬傷,但是病灶對局 ..................More
  An Asymptomatic Nodule on the Lower Eyelid
Chia-Cheng Wu, Jau-Shiuh Chen
Dermatol Sinica 23:52-53,2005

CASE REPORT A 46-year-old Taiwanese male presented with an erythematous nodule on the left lower eyelid for 3 months. He had no other medical disorder and denied trauma history at the lesional site. The nodule was asymptomatic and developed spontaneous ulceration at its center. Physical examination revealed a 0.6 x 0.4-cm nodule with central ulceration on the margin of the left lower eyelid (Fig. 1). An incisional biopsy was performed and the histological pictures were shown in Fig. 2-4. ..................More
  Multiple Vesicles over Sun Exposed Area in a 20-year-old Man
Yi-Chiun Lin, Jui-Lung Shen, Jen-Hung Yang
Dermatol Sinica 23:54-55,2005

Case Report A 20 year-old Taiwanese male patient presents at clinic with vesicles on sun-exposed skin areas, including ear, face, neck, outer upper limb and leg. (Fig. 1A) This patient’s age at onset was 8 year-old and the symptoms include erythematous, itchy papules that would subsequently turn to vesicles resulting in pitting scar formation after complete recovery within minutes or hours of sun exposure. Clinical examination reveals several clear and transparent vesicles on arms, many pitti ..................More
  Nonhealing Perianal Ulcers
Jen-Chin Wu , Tien-Yi Tzung
Dermatol Sinica 23:56-57,2005

CASE REPORT A 67-year-old heterosexual Chinese male presented with a one-year history of persistent multiple painful well-defined punched-out ulcers around the anus and in the perineum without involvement of anal mucosa (Fig. 1). There was no lymphoadenopathy on the groin. He had been treated as herpes simplex viral infection with topical and oral antiviral agents without improvement. In addition, he was known to have central diabetes insipidus for 14 years and received nasal desmopr ..................More
  Universal Small White Macules with Autosomal Dominance in a 19-year-old Female
Hsin Huang, Tzei-Yi Lin, Chau-Hong Liu
Dermatol Sinica 23:58-59,2005

Case Report A 19-year-old girl with skin phototype IV visited our ward complaining of spotted hypopigmentation on her neck, trunk, and extremities. (fig 1) The history could be traced back to her infancy when a few pin-point whitish spots were noted on her abdomen. Those spots increased in size and number during her childhood with dissemination to her whole trunk, legs and arms. A significant exaggeration of this condition with almost tripled density of these lesions occurred in rece ..................More
  Multiple Hypopigmented Patches Over Trunk in a 17-year-old Girl
Yi-Chiun Lin, Yi-Ju Chen, Jui-Lung Shen
Dermatol Sinica 23:60-61,2005

Case Report A healthy 17-year-old Taiwanese girl had a 10-year history of hypopigmented patches on trunk, and was previously diagnosed as non-specific dermatitis at clinics for years. She had no symptoms of atopy or other medical problems. Physical examination revealed multiple hypopigmented, well-demarcated, non-scaly macules and patches over trunk, buttock and proximal limbs (Fig 1), sparing her face, hands, palms and soles. No lymphadenopathy was found. No contact history, drug hi ..................More
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