Back issues No.1 - 2007  
  Foam for enhanced topical delivery: an overview
Hanafi Tanojo , Xinfan Huang , Howard I. Maibach
Dermatol Sinica 25 : 10-15, 2007

ABSTRACT    Foam dosage form is excellent for topical application of active compounds into skin because it can increase compound partition and penetration rate. Due to unique film forming and breaking characteristics, foam can be easily transferred from the container to the intended skin application site. This advantage can particularly be enhanced using thermo-sensitive materials in the formulations. Foams can be formulated to provide moisturizing effects to the skin. Studies demonstrat ..................More
  Original Study
  Reevaluation of Behcet’s Disease Patients in Dermatological Department of Chang Gung Memorial Hospital, Kaohsiung, Based on the Working Guideline Proposed by International Team for the Revision of International Criteria for Beh^et’s Disease
Yi-Chien Yang , WenChieh Chen , Ji-Chen Ho , Yu-Wen Cheng
Dermatol Sinica 25 : 1-9, 2007

Behcet’s disease is a chronic systemic inflammatory disorder of unknown etiology. The diagnosis is made by clinical criteria, as no pathognomic laboratory tests or histologic findings exist. Since 2005 there have been 27 countries participating in a project aiming to validate or revise the actual International Criteria for Beh^et’s Disease. We review and analyze 17 cases (7 men and 10 women) of Behcet’s disease diagnosed in our department during the period between 1995 to 2005, based on th ..................More
  Case Report
  Gemcitabine-induced Linear IgA Bullous Dermatosis
Hsiao-Feng Liao, Chun-Hsuan Ho*, Hsuan-Hsiang Chen*
Dermatol Sinica 25 : 16-19, 2007

We describe a 67-year-old man with non-small cell lung cancer in stage IV, who developed palpable purpura with bullae over his trunk and legs 12 days after treatment with gemcitabine. Histologically, a large subepidermal bulla with a mixed cell infiltrate of neutrophils and eosinophils was seen. Direct immunofluorescence of perilesional skin showed linear IgA staining along the dermoepidermal junction, which leaded to the diagnosis of gemcitabine-induced linear IgA bullous dermatosis (LABD). The ..................More
  Granular Parakeratosis -Report of Two Cases
Yi-Shuan Sheen , Cheng-Shiang Shiao , Tsen-Fang Tsai
Dermatol Sinica 25 : 20-23, 2007

Granular parakeratosis (GP) is an uncommon, benign cutaneous eruption of intertriginous areas that represents a distinctive clinicopathologic entity. Clinically, GP presents with variably pruritic, hyperkeratotic, fissured papules and plaques over an erythematous base, affecting the cutaneous folds. Histological examination shows a characteristic picture with presence of abundant basophilic keratohyaline granules within a compact, hyperparakeratotic stratum corneum. We describe two cases of gran ..................More
  Systemic Contact Dermatitis from Valacyclovir -A Case Report and Review of the Literature
Cheng-Han Yang , Chia-Yu Chu
Dermatol Sinica 25 : 24-29, 2007

Acyclovir is a widely used antiviral drug. However, allergic contact dermatitis caused by acyclovir is uncommon. We herein report a 48-year-old woman, who had been diagnosed as having adenocarcinoma of the upper lobe of the right lung, developed systemic contact dermatitis sensitized by topical acyclovir therapy first, and triggered by re-exposure of oral valacyclovir and topical acyclovir therapy. A control study of 33 healthy volunteers patch tested with acyclovir (10% aq.) showed they were al ..................More
  Protein Contact Dermatitis:-A Case Report
Szu-Chi Lin , Mei-Eng Tu , Yang-Chih Lin
Dermatol Sinica 25 : 30-34, 2007

Protein contact dermatitis is a unique occupational dermatitis with a characteristic episodic, eczematous, itchy vesicular eruption mostly on the hands of food handlers. It usually develops several minutes after handling the offending allergens. It is either a combined type I and type IV or a type I hypersensitivity reaction alone. The diagnosis is made by skin prick or scratch test using the causative agents. We report such a case in a 28-year-old baker, a patient with chronic hand eczema, who ..................More
  Diagnostic Confirmation of X-linked Recessive Ichthyosis by Fluorescent in Situ Hybridization-A Case Report
Chiu-Yen Ho, Kuo-Chia Yang , Ming Chen, Shun-Ping Chang, Pao-Lun Yin
Dermatol Sinica 25 : 35-42, 2007

X linked ichthyosis is a hereditary genetic disorder resulting in abnormal turnover of the epidermis. The majority of patients are males who inherit a defective maternal X-chromosome. Clinically, patients present with varying degrees of generalized desquamation. Other extra-cutaneous manifestations include corneal opacities and crypto-orchidism. We report a 32 year-old male patient who came to our clinic with the presentation of generalized desquamation combined with polygonal, brown scales on t ..................More
  Kwashiorkor and Concurrent Acquired Acrodermatitis Enteropathica in a Case with Hirschsprung’s Disease-A Case Report and Review of the Literature
Yi-Shan Liu , Pei-Yu Lo , Tien-Yi Tzung , I-Fei Huang
Dermatol Sinica 25 : 43-47, 2007

Kwashiorkor is a form of protein-energy malnutrition with a characteristic “flaky paint” dermatosis. Patients with kwashiorkor may have a low serum level of zinc. However, most patients fail to show the typical cutaneous manifestation of zinc deficiency, namely, acrodermatitis enteropathica. We herein reported a patient with concurrent kwashiorkor and acquired acrodermatitis enteropathica. This 2-year-and-8-month-old boy, a case of Hirschsprung’s disease, was admitted due to enterocolitis. ..................More
  Psoriatic Scarring Alopecia-Report of Two Cases
Ming-Hsiung Yeh Tsen-Fang Tsai Cheng-Hsiang Hsiao
Dermatol Sinica 25 : 48-52, 2007

Psoriasis affects approximately 0.123% of the population in China. Scalp is the first site of involvement in nearly 50% of the patients. Hair loss is a possible feature in psoriasis of any type. In 1972, Shuster has first distinguished three types of psoriatic alopecia: circumscribed alopecia, diffuse alopecia, and scarring alopecia. Psoriatic alopecia was found to be circumscribed in 75% of the cases and diffuse in 25%. Scarring alopecia is a rare form, which most often occurs in areas of long- ..................More
  Cytophagic Histiocytic Panniculitis -Acase report and Review of the Literature
Chi-Ling Lin Gwo-Shing Chen
Dermatol Sinica 25 : 53-58, 2007

Recently, we evaluated a 4-year-old boy with fever, abdominal pain and multiple reddish blue subcutaneous nodules of the low back and the extremities, especially of the lower legs for 10 days. Laboratory studies showed leukocytosis, thrombocytopenia and liver dysfunction. The bone marrow aspiration excluded a proliferative disease of the haematopoietic or lymphatic system. Serological tests excluded virus infections. In the histopathologic examination of skin biopsy, there was an intense inflamm ..................More
  The Hyperkeratotic Variant of Disseminated Superficial Actinic Porokeratosis─A Prurigo Simulator
Chia-Mao Tsai , Tsen-Fang Tsai , Feng-Sheng Kuo , Yu-Fu Chen , Chih-Ming Hung
Dermatol Sinica 25 : 59-66, 2007

Disseminated superficial actinic porokeratosis (DSAP) is a hereditary disease which involves mainly the extremities, especially sun-exposed areas. The typical lesions show papules or plaques with slightly atrophic centers and peripheral ridges, and the pathological features reveal characteristic cornoid lamella-a parakeratotic column on the epidermis. DSAP is not a rare disease, but the hyperkeratotic variant is uncommon. Only one case was reported previously. We report a 81-year-old man whose c ..................More
  Elevated Serum Tissue Polypeptide Antigen in a Patient with Mycosis Fungoides
Chu-Sung Hu , Chi-Ling Lin , Gwo-Shing Chen , Cheng-Che Lan
Dermatol Sinica 25 : 67-72, 2007

Tissue polypeptide antigen (TPA) is a tumor marker which has been found to be elevated in various solid tumors, including cancers of the lung, breast, and bladder. However, there have been very limited reports regarding the association of this tumor marker with hematologic malignancies. We here report a patient with mycosis fungoides (MF), presenting with generalized scaling involving >90% of the total body surface area, erythema of buttocks and thighs, bilateral inguinal lymphadenopathy, and a ..................More
  Low-Dose Methotrexate-induced Severe Pancytopenia in One Patient with Psoriasis Undergoing Hemodialysis
Hsiu-Hui Chiu , Wen-Yu Chang , Gwo-Shing Chen
Dermatol Sinica 25 : 73-75, 2007

A 54-year-old male with psoriasis for about 40 years admitted due to psoriatic erythroderma. He was also a victim of diabetic mellitus and uremia undergoing hemodialysis (HD) for about two years. Besides, he took folic acid 5 mg per day for years because of macrocytic anemia. Tracing back his history, he was treated at our clinic for about 30 years and received methotrexate (MTX) treatment many times in the past 30 years before renal function was deteriorated. No serious complication was noted. ..................More
  Resident Forum
  Diffuse Symmetric Intertriginous Erythema in a 39-year-old Woman
Szu-Chi Lin , Mei-Eng Tu , Yang-Chih Lin
Dermatol Sinica 25 : 76-77, 2007

CASE REPORT   A 39-year-old woman presented to our out-patient department with a diffuse skin rash symmetrically distributed over the neck, submammary areas, axillae, antecubital fossae, groins, buttocks, and upper inner thighs. Four days previously, she had been exposed to mercury vapor after accidentally breaking a thermometer at home. About one day after the mercury exposure, a slightly itchy erythematous rash began to appear on the flexural and friction areas of her body. It then rapidl ..................More
  A Subcutaneous Nodule on Neck in 13-year-old Girl
Chia-Mao Tsa, i Tsen-Fang Tsai, Yu-Fu Chen, Chih-Ming Hung
Dermatol Sinica 25 : 78-79, 2007

CASE REPORT A 13-year-old girl presented with a subcutaneous nodule on left neck since she was a toddler. The girl is in good health. The skin lesion was asymptomatic for most of the time. The lesion may become tender, enlarged, or inflamed sometimes, especially when she caught a cold. Occasionally, it may develop abscesses with purulent draining. There was no history of similar lesions in her family members. On physical examination, the skin lesion was a smooth, nontender, skin-colored, s ..................More
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