Back issues No.2 - 2007  
  Original Study
  Comparison of intradermal and intramuscular injection technique in the treatment of inferior periorbital rhytids
Chun-tang Chiu Wu-hui Chang Kuo-Chia Yang
Dermatol Sinica 25: 88-94, 2007

Botulinum toxin type A (Botox(r)) is well documented as a useful therapy for smoothening dynamic facial rhytids of the upper face. Most controlled studies have focused on the treatment of glabellar frown lines, horizontal forehead lines, and crow’s feet1. Reports of Botulinum toxin type A use in the inferior periorbital rhytids are few and anecdotal2, 3. We present our experience comparing intradermal and intramuscular injection with Botulinum toxin type A in inferior periorbital region for ..................More
  Pemphigus - Clinical Analysis of 129 Cases
Ke-Jen Yu , Lih-Jen Yang , Yue-Zon Kuan , Hsin-Chun Ho , Hong-Shang Hong
Dermatol Sinica 25: 95-102, 2007

Pe antibody titer of mucocutaneous type pemphigus vulgaris was significantly higher than that of either mucosal or cutaneous type pemphigus vulgaris (P = 0.002, P = 0.019). Complication rate was 57%. These included infections (dermatophytosis, candidiasis, bacterial infection, HSV/HZV, warts, UTI, pulmonary tuberculosis and pulmonary nocardiosis), acne / folliculitis, hypoalbuminemia, hypokalemia, hyperglycemia, GI problem (GI upset / PU / UGI bleeding), Cushing’s syndrome, Osteroporosis / ost ..................More
  Clinical Analysis of Psoriatic Inpatients-A 10-year Retrospective Study
Ming-HsiungYeh , Tsen-Fang Tsai
Dermatol Sinica 25: 103-111, 2007

Psoriasis is a common chronic inflammatory skin disease that is usually managed in outpatient clinic. There is a trend to reduce hospitalization for psoriasis globally in recent years. To analyze the reasons necessitating hospitalization for psoriasis, especially the causes of acute exacerbation, a retrospective study was carried out in psoriatic inpatients admitted to National Taiwan University Hospital between April 1996 and April 2006. Available data were obtained from 120 patients. On averag ..................More
  Case Report
  Rose Spots in Non-typhoidal Salmonellosis - a case report
Chang-Lin Tsai , Lin-Hui Su , Cheng-Hsiang Hsiao , Yu-Ling Hsu, Ying-Jui Chang
Dermatol Sinica 25: 112-114, 2007

Rose spots are known as one of the symptoms of the untreated typhoidal salmonellosis patients. However, they are rarely seen or reported in patients with bacteremia caused by other species of salmonella. In this article, we report a man who manifested with productive cough, mild fever, general weakness, and drowsiness. Pneumonia, urinary tract infection and anemia were impressed initially. After admission, he developed fever, diarrhea, and leukocytosis. Erythematous papules were noted over the t ..................More
  Nail-splinting Method With Plastic Tubes for Ingrown Toenails
Sheng-Cheng Tsai , Han-Nan Liu , Chao-Wen Hsueh
Dermatol Sinica 25: 115-118, 2007

ngrown toenail is a common disorder in the great toe. Many factors involved include a combination of chronic trauma from tight shoes and improper trimming of the nail. Many treatments have been described for ingrown nails. But they have many disadvantages, such as a prolonged wound-healing period, the production of an unsightly nail, or the restriction of normal activities. We performed a modified method of lateral nail manipulation with placement of splints on 6 patients who gained instant reli ..................More
Chih-Chieh Chan , Cheng-Hsiang Hsiao , Tsen-Fang Tsai
Dermatol Sinica 25: 119-123, 2007

Monilethrix, a rare congenital trichodystrophy, is characterized by fragility of scalp hair with partial or total alopecia. Affected individuals may have a variable degree of follicular hyperkeratosis and nail changes. Some monilethrix has been reported to be associated with genetic mutations on human keratins. Mutation in DSG4 has also been reported. Some patients could find a family association. To date, several treatments have been introduced. However, there is still no effective treatment fo ..................More
  Syringoid Eccrine Carcinoma - A Case Report
John Tsai , Chieh-Shan Wu , Gwo-Shing Chen
Dermatol Sinica25: 124-127, 2007

Syringoid eccrine carcinoma (SEC) is a rare cutaneous malignant tumor thought to be derived from eccrine sweat apparatus. They may be locally aggressive and have an infiltrative growth pattern. Because of their rarity, the origin and differentiation of this tumor has not been confirmed completely. Variable clinical appearance and diverse histologic findings often makes diagnosis difficult. We report a 71-year-old female with an asymptomatic brownish nodule located on the medial side of right ..................More
  A Novel Splicing Mutation of the CYLD Gene in a Taiwanese Family with Multiple Familial Trichoepithelioma
Chien-Te Lin , J. Yu-Yun Lee , Sheau-Chiou Chao
Dermatol Sinica 25: 128-131, 2007

Multiple familial trichoepithelioma (MFT) is an autosomal dominant skin disorder that is characterized by childhood onset of numerous skin-colored papules and nodules on the central face that originate from hair follicles. Mutations in CYLD, the disease gene of familial cylindromatosis, have recently been detected in several families presented with MFT phenotype. CYLD has been shown to be a tumor suppressor gene. CYLD functions as a negative regulator of the transcription factor NF-B, which p ..................More
  Hailey-Hailey Disease Successfully Treated with Carbon Dioxide Laser - A Case Report
Yu Chuan Lin , Chung Hsing Chang
Dermatol Sinica 25: 132-135, 2007

A 45-year-old man presented with erythematous vesicles and erosions on an erythematous background of his axillae, groin, and popliteal fossae. He had been treated with corticosteroid ointments for several years, but the clinical course waxed and waned, and the lesions never completely disappeared. A skin biopsy specimen from his left axilla revealed suprabasal acantholysis (a "dilapidated brick wall"). Diagnosis of recurrent Hailey-Hailey disease (HHD) was made after careful analysis of the cli ..................More
  Cutaneous Side Effects Caused by Gefitinib Treatment of Lung Cancer- Case Report and Review of Literature
Chin-Pei Tein , Shu-Hui Wang , Ching-Chi Chi , Tseng-tong Kuo , Cheng-Ta Yang
Dermatol Sinica 25: 136-141, 2007

Gefitinib is an oral inhibitor of epidermal growth factor receptor-tyrosine kinase (EGFR-TK) that is currently used as molecular target therapy for a number of solid malignancies. In recent years, gefitinib has gained popularity in treating advanced non-small cell lung cancer (NSCLC). Herein we report a 69-year-old woman with NSCLC developed cutaneous side effects after receiving gefitinib therapy. Oral ulcers were noted 6 weeks after the initiation of gefitinib therapy. Acneiform eruptions on h ..................More
  Orientia Tsutsugamushi- Induced Leukocytoclastic Vasculitis- A Case Report
Shih-Ming Tseng1, Yu-Ping Hsiao1, Hung-Jin Shih1, Yung-Hsiang Hsu 2 Jen-Hung Yang*1
Dermatol Sinica 25: 142-146, 2007

Scrub typhus (also named Tsutsugamushi disease), a mite-transmitted zoonosis caused by Orientia tsutsugamushi, is an endemic infectious disease in east Asia and Australia. This disease usually presents as an acute febrile illness with non-specific symptoms. We reported a case of the scrub typhus with leukocytoclastic vasculitis (LCV) who suffered from acute pyrexia of unknown origin and arthralgia. Weil-Felix test and indirect immunofluorescent antibody (IFA) technique revealed positive findings ..................More
  Mucinous Nevus-A Case Report and Reviewof Literature
Hsiu-Hui Chiu , Wen-Yu Chang , Gwo-Shing Chen
Dermatol Sinica 25: 147-152, 2007

Mucinous nevus (MN) is a very rare entity and can be classified as both a cutaneous mucinosis (CM) and a connective tissue nevus (CTN). We describe the clinicopathologic features of an unusual case of mucinous nevus in a 9-year-old Taiwanese boy who presented with multiple grouped flesh-colored nodules with band-like distribution on his right thigh since birth. Histopathological examination of the skin lesion showed alcian blue (pH 2.5) and toluidine blue(pH 2.5) positive mucin deposited betwe ..................More
  Association of HPV type 16 and 49 in Multiple Acral Squamous Cell Carcinomas
Hsiao-Feng Liao , Ming-Hsiu Lin , Cheng-Hsiang Hsiao , Yi-Hua Liao
Dermatol Sinica 25:153-158, 2007

We report a case with multiple acral squamous cell carcinomas (SCCs) associated with human papillomavirus (HPV) type 49 and 16 infection in separate lesions. HPV 49 belongs to the epidermodysplasia verruciformis (EV)-HPV group. It has only been detected in flat warts and one SCC in a renal transplant patient in the past literature. We report showed the first case of SCC associated with HPV 49 in an immunocompetent patient. In addition, the high risk mucosal HPV 16 DNA was also detected in a palm ..................More
  Recurrent Dermatofibrosarcoma Protuberans of the Scalp followed by Brain Metastasis- A Case Report with Literature Review
Yi-Chien Yang , Yu-Wen Cheng
Dermatol Sinica 25: 159-164, 2007

Dermatofibrosarcoma protuberans (DFSP) is a fibrohistiocytic tumor of intermediate malignancy. It is characterized by a locally aggressive growth and a high rate of local recurrence. Metastases are very rare and the most common sites of metastasis are the lungs and lymph nodes. We report a 53-year-old female patient with a DFSP on the scalp. She developed local recurrence of DFSP 4 years after simple excision and right frontal lobe metastasis in the sixth year. The pathological examinations reve ..................More
  Squamous Cell Carcinoma of the Scalp Arising from Chronic Discoid Lupus Erythematosus with Scarring Alopecia
Chu-Sung Hu , Yu-Wen Chen , Gwo-Shing Chen , Shih-Tsung Cheng
Dermatol Sinica 25: 165-170, 2007

Neoplasms have rarely been reported in lesions of lupus erythematosus (LE) and have included basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and atypical fibroxanthoma. We here report a case of SCC of the scalp arising from a patch of scarring alopecia secondary to chronic discoid lupus erythematosus (DLE). Surgical excision of the tumor with a 1cm margin was performed, showing a deeply invasive SCC extending to the deep fascia. A series of staging investigations were undertaken, incl ..................More
  Use of CO2 Laser in the Treatment of Periungual Fibromas of Tuberous Sclerosis Complex
Chen-Hsi Hung , Kuo-Chia Yang
Dermatol Sinica 25: 171-172, 2007

CASE REPORT A 47-year-old woman came to our dermatological out-patient department due to multiple tender tumors on her toes for years. On physical examination, she was found to have firm, discrete, red-brown, telangiectatic papules, extending from the nasolabial furrows to the cheeks (Fig. 1). In addition, firm, flesh-colored excrescences emerging from the toenail folds were present (Fig. 2). She developed these extensive facial tumors when she was in the kindergarten. The periungual papules f ..................More
  Resident Forum
  Numerous Minute Round Glistening Papules on Photodistributed Skin in a 4-year-old Boy
Chien-Te Lin , Kung-Kai Lin , Gwo-Shing Chen
Dermatol Sinica 25: 173-174, 2007

CASE REPORT A 4-year-old boy experienced numerous minute, round, glistening, flat-topped, flesh-colored to pink or reddish-brown papules, 1 to 3 mm in diameter, on the face, dorsa of hands, extensor aspects of forearms and lower legs of 2 year’s duration (Fig. 1). There was a history of summer exacerbation with occasional pruritus. No other part of the body was affected. The palms, soles, nails, mucous membranes, and scalp were spared. He had been in good health and there was no previous his ..................More
  Several Erythematous Papules with a 1.5-cm Sized Nodule Scattering on the Face of an Old Woman
Shiou-Han Wang , Tsen-Fang Tsai
Dermatol Sinica 25: 175-176, 2007

CASE REPORT A 67-year-old woman presented with a 4-month history of asymptomatic papules on the face. She was a housewife with unremarkable past medical history. On physical examination, these dome-shaped papules were variably sized with erythematous hue, and some of them showed tendency to confluence. They were disseminated on the periorbital and paranasal regions. Both cheeks were also involved. A large brownish red nodule measuring 1x1.5-cm in size was noted on the right upper eyelid. Some ..................More
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