Back issues No.2 - 2008  
  A new Perspective of Autoimmune Bullous Diseases: Molecular Cell Biology of Blistering Mechanisms and Logical Treatments
Yasuo Kitajima
Dermatol Sinica 26: 52-64, 2008

Pemphigus and pemphigoid are most distinct types of organ-specific acquired autoimmune diseases, and characterized by intraepidermal and subepidermal blistering, which are induced by autoantibodies against desmosomal cadherins, desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3), and a hemidesmosome adhesion protein, type XVII collagen, i.e., bullous pemphigoid antigen II (BP180), respectively. Blistering pathomechanisms after autoantibodies bind to their antigens are not yet clear. In pemphigus vul ..................More
  Original Study
  Ofuji’s Disease: A Review of 34 Patients in 10 Years
Jia-Jen Wu Chia-Yu Chu
Dermatol Sinica 26: 65-74, 2008

Ofuji’s disease is clinically characterized by chronic and recurrent annular clusters of sterile follicular papules and pustules superimposed on plaques with central clearing and peripheral extension. Indomethacin is considered to be a first choice of treatment, but the pathogenesis of this disease is still obscure. Although most cases of Ofuji disease have been reported in Japanese people, it is not rare in Taiwan according to our clinical experience. In this study, we reviewed 34 patients ..................More
  Case Report
  Generalized Argyria-A Case Report
Chin-Ya Yang Yi-Ju Chen Jui-Lung Shen
Dermatol Sinica 26: 75-79, 2008

Generalized argyria is a rare disease caused by deposition of silver in the skin, nails, mucous membranes, and internal organs. It is characterized by a diffuse slate-blue discoloration in sun-exposed areas. Here, we report a case of 38-year-old woman with generalized argyria. Pathologically, there were numerous minute fine brownish-black pigments fairly uniform in size, which were observed in the dermal interstitium, around the hair follicles, sebaceous glands, eccrine glands and the walls of c ..................More
  Congenital Self-Healing Reticulohistiocytosis Presenting as Hypopigmented Macules and Papules in a Neonate
Shyue-Luen Chang I-Hsin Shih Tseng-Tong Kuo I-Chieh Lai Ching-Chi Chi Chih-Hsun Yang
Dermatol Sinica 26: 80-84, 2008

Congenital self-healing reticulohistiocytosis, also known as Hashimoto-Pritzker disease) is a rare variant of Langerhans cell histiocytosis. It is characterized by developing multiple or single red-brown papules, nodules or vesicles at birth or first few weeks of life and involutes spontaneously without systemic involvement of other organs. We report a rare case of female neonate presented with multiple white macules and papules on trunk. Langerhans cell histiocytosis is diagnosed by histologica ..................More
  Generalized Immunosuppression-Associated Type Kaposi’s Sarcoma in a Patient with Severe Refractory Bullous Pemphigoid
Teh-Yang Cheng Cheng-Hsiang Hsiao Chia-Yu Chu
Dermatol Sinica 26: 85-92, 2008

The progression of immunosuppression-associated type Kaposi sarcoma (KS) is thought to be related to the immunocompromised status. We herein describe a case, who had a quiescent initial lesion of KS developed in the sixth month after receiving immunosuppressive therapy for treating the refractory bullous pemphigoid. The activity of KS increased abruptly during a period of lymphocytopenia. Subsequent analysis showed CD4+ lymphocytopenia and negative anti-HIV antibody. While the dosage of corti ..................More
  Rhabdomyomatous Mesenchymal Hamartoma Associated with Congenital Anomalies: Report of an Unusual Perineal Case
Jia-Ru Wang Tseng-Tong Kuo Ke-Jen Yu Po-Yu Shih Yue-Zon Kuan Chih-Hsun Yang
Dermatol Sinica 26: 93-98, 2008

The ectopic occurrence of skeletal muscles in skin is an unusual condition. These lesions are named rhabdomyomatous mesenchymal hamartoma now. More accurately speaking, this entity should be called utaneous rhabdomyomatous choristoma?because the skeletal muscle is not a normal element in skin. We described a case occurring in perineal region associated with amniotic band syndrome, imperforate anus, and intestinal atresia. The association with gastrointestinal tract anomaly has not been report ..................More
  Linear Focal Elastosis-A Case Report
Tsung-Mao Huang Julia Yu-Yun Lee Chao-Chun Yang
Dermatol Sinica 26: 99-106, 2008

Linear focal elastosis (LFE) is a disorder of elastic fibers characterized by palpable, yellowish, linear striae distributed horizontally over the mid and lower back. Histologically, the findings are increased amounts of elastic fibers with a fairly thin, wavy, elongated and fragmented morphology. The most important differential diagnosis of LFE is striae distensae which is mainly a disorder of collagen fibers. We reported a 17-year-old male with typical LFE. Through this report, we hope to rais ..................More
  Collagenous and Elastotic Marginal Plaques of the Hands-A Case Report
Song-Jen Hong Chung-Hsing Chang
Dermatol Sinica 26: 107-111, 2008

Collagenous and elastotic marginal plaques of the hands is a rare acquired slowly progressive and asymptomatic dermal connective tissue abnormality. Herein, we present a 72-year-old man with a 2-3 year history of asymptomatic symmetrical sclerotic linear plaques extending along the junction of the dorsal and palmar skin of the hands from the lateral aspect of the thumb to the medial aspect of the index finger. He was a farmer. No other family members had similar symptoms. A skin biopsy showed ..................More
  Use of Non-contact Dermatoscopy in the Diagnosis of Scabies
Ming-Yun Wu Shu-Lin Hu Che-Hao Hsu
Dermatol Sinica 26: 112-114, 2008

A 15-year-old girl came to our out-patient clinic due to many itchy vesicles and papules on her bilateral palms for several years. She visited other hospital and was treated as hand eczema prior to this visit. Physical examination showed multiple, 0.3 to 0.5 cm, mild scaly, erythematous papules and deep-seated vesicles on her bilateral palms (Fig. 1). There was also one serpiginous, whitish to grayish, threadlike elevated line ( burrow) 2.5 cm in length on her left palm. Under handheld dermatosc ..................More
  Resident Forum
  An Asymptomatic Nodule on the Neck of a 10-year-old Boy
Horng-Shin Lin Hung-Chun Shih Yu-Ping Hsiao Shiou-Jiuan Wei Jen-Hung Yang
Dermatol Sinica 26: 115-116, 2008

A 10-year-old boy was found to have an asymptomatic solitary flesh-colored nodule over his neck since infancy. He was born in full term, and was healthy without any other congenital defects or deficits. Family history was non-contributory. The skin examination revealed a protruding solitary, non-tender elastic-firm, deep-seated but freely-movable subcutaneous nodule. The nodule was 1 cm in diameter located over right lower third lateral aspect of neck (Fig. 1). The nodule was totally excised for ..................More
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