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Diagnostic Immunopathology in 21ST Century Dermatology Part I: Basics and Epidermal Deposits
Maria Jasmin J. Jamora
Dermatol Sinica 26: 119-137, 2008
Immunofluorescence techniques and other immunopathologic diagnostic techniques in
dermatology involve the detection and localization of specific autoantibodies against various antigens
within the skin. Since the 1960s when the lupus band test was utilized to diagnose lupus
erythematosus, diagnostic immunopathologic techniques, when interpreted alongside clinical and
histopathologic findings, have become a part of the diagnostic criteria in the diagnosis of many
skin diseases, in particular ..................More |
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Tufted Angioma: A Retrospective Analysis of 45 Cases
Yi-Lun Tsai I-Hsin Shih Hong-Shang Hong
Dermatol Sinica 26: 138-144, 2008
Tufted angioma (known in Japanese literature as angioblastoma of Nakagawa) is an uncommon
vascular tumor. Although histologically benign, tufted angioma may be disfiguring because
of the disease’s potential for infinite proliferation and a predilection for the head and neck. There
is a lack of epidemiological reports on tufted angioma among Taiwanese and also a dearth of
therapeutic guidelines. We retrospectively analyzed 45 histologically-confirmed cases (25 men,
20 women) of tufted angi ..................More |
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Aquagenic Syringeal Acrokeratoderma
Hsing-Chuan Lee Tsen-Fang Tsai
Dermatol Sinica 26: 145-150, 2008
Aquagenic syringeal acrokeratoderma is a newly described disease entity of unclear etiology,
affecting predominantly adolescents and young adults. It manifested as multiple whitish
papules on the palms or rarely soles, which became accentuated after immersion in water and
improved after drying the involved area. Burning, pain, pruritus or tightening sensation may
be present and usually there is an association with palmar hyperhidrosis. The histopathology
revealed dilated sweat duct ostia wi ..................More |
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Keratitis, Ichthyosis and Deafness Syndrome-A Case Report and Literature Review
Chin-Ya Yang Yi-Ju Chen Jui-Lung Shen
Dermatol Sinica 26: 151-156, 2008
The acronym “KID syndrome” was proposed by Skinner et al. in 1981 to represent keratitis,
ichthyosis and deafness. It is a rare syndrome and about 70 cases have been reported. Herein,
we report a 28-year-old male with keratoderma, bilateral deafness, total blindness, alopecia and
cerebellar hypoplasia. Our patient started to have walking difficulties at the age of 6 and is now
bed-ridden. Several huge erythematous plaques with verrucous surface were noted over the lower
limbs. Squamous ..................More |
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Aplasia Cutis Congenita Associated with Cutis Marmorata Telangiectatica Congenita, Atrial Septal Defect, and Epilepsy: A Newly Recognized Syndrome?
Jeng-Feng Chen Shi-Chou Chen Chien-Ping Chiang
Dermatol Sinica 26: 157-164, 2008
Aplasia cutis congenita (ACC) is a rare developmental malformation characterized by the
absence of skin, and often extends to bone or dura in a localized or widespread area at birth.
ACC is seen most commonly on the scalp reported up to eighty-four percent of all cases in the
literature. It often manifested as a solitary lesion without other anomalies, but sometimes represented
as part of a heterogenous group of disorders. We presented a case of ACC associated
with cutis marmorata telangiec ..................More |
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Herpes Simplex Virus-Associated Recurrent Erythema Multiforme: The Implication of MHC Class Molecules on Susceptibility
Yu-Chi Chen Chung-Hsing Chang
Dermatol Sinica 26: 165-170, 2008
Erythema multiforme is an acute mucocutaneous hypersensitivity reaction caused by a variety
of etiologies. Here we report a case of herpes simplex virus-associated recurrent erythema
multiforme. This 21-year-old male presented with recurrent oral ulcers for more than 10 years.
During the last two years, multiple erythematous to violaceous papules and plaques with a central
vesicle over all four limbs had developed 10 to 14 days after the occurrence of oral ulcers.
The patient’s blood test ..................More |
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Bullous Pemphigoid with Esophageal Involvement Presenting as Exfoliative Esophagitis and Acute Upper Gastrointestinal Bleeding: Reports of Two Cases and Review of the Literature
Wei-Hsin Wu Chia-Yu Chu
Dermatol Sinica 26: 171-179, 2008
Bullous pemphigoid is the most common autoimmune blistering skin disease usually occurs
in the elderly. The characteristic skin lesions present large and tense blisters arising on normal,
erythematous, or urticarial bases and most commonly involve lower abdomen, inner thighs and
flexural areas. The mucous membrane lesions occur in about 10 to 35 percent of patients and are
almost limited to the oral mucous membrane. Esophageal involvement is a rare condition which
may be completely asymptom ..................More |
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Milia En Plaque - A Case Report
Li-Kai Lo Tsen-Fang Tsai Chih-Ming Hung Yu-Fu Chen Wang-Cheng Ko
Dermatol Sinica 26: 180-184, 2008
‘Milia en plaque’ is a rare disease entity with unclear pathogenesis but distinctive histopathology.
No more than 30 cases have been recorded in the world’s literature. Most of them
occurred in the peri-auricular area. There were no optimal treatments. We describe a 65-yearold
man with a flesh-colored plaque embedded with tiny globoid cysts on his left cheek, which
developed in one year. Combined its clinical and histopathological findings, we concluded it as
milia en plaque and treat ..................More |
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Multiple Painful Ulcers of a 42-year-old Man
Wei-Hsuan Huang Yeu-Chin Chen Chien-Ping Chiang
Dermatol Sinica 26: 185-186, 2008
A 42-year-old male suffered from multiple painful ulcers surrounding by raised, undermined
borders over his face, trunk, and legs for 2 months (Fig. 1A, 1B). The skin lesions responded
poorly to antibiotics. Laboratory examinations showed leukocytosis with monocytosis,
anemia, and thrombocytopenia. A biopsy from the edge of one ulcer showed hemorrhagic necrosis
and a dense infiltration of neutrophils extending throughout the dermis to the subcutis (Fig. 2).
A chest X-ray showed several soft ..................More |
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Multiple Vegetating Granulomatous Nodules in a 94-year-old Man
Yi-Chieh Lin Chien-Ping Chiang
Dermatol Sinica 26: 187-188, 2008
A 94-year-old male patient presented with multiple vegetating and granulomatous nodules
on the right groin and gluteal region in the recent one year (Fig. 1A). He was robust before without
any other systemic diseases except oral erosion developed one week before he visited our
clinic. Tentative diagnosis included cutaneous fungal infection, cutaneous T cell lymphoma, and
vegetating blistering disease. Bacterial and fungal culture showed no growth of microorganism.
An incisional biopsy was p ..................More |
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