Back issues No.3 - 2008  
  Diagnostic Immunopathology in 21ST Century Dermatology Part I: Basics and Epidermal Deposits
Maria Jasmin J. Jamora
Dermatol Sinica 26: 119-137, 2008

Immunofluorescence techniques and other immunopathologic diagnostic techniques in dermatology involve the detection and localization of specific autoantibodies against various antigens within the skin. Since the 1960s when the lupus band test was utilized to diagnose lupus erythematosus, diagnostic immunopathologic techniques, when interpreted alongside clinical and histopathologic findings, have become a part of the diagnostic criteria in the diagnosis of many skin diseases, in particular ..................More
  Original Study
  Tufted Angioma: A Retrospective Analysis of 45 Cases
Yi-Lun Tsai I-Hsin Shih Hong-Shang Hong
Dermatol Sinica 26: 138-144, 2008

Tufted angioma (known in Japanese literature as angioblastoma of Nakagawa) is an uncommon vascular tumor. Although histologically benign, tufted angioma may be disfiguring because of the disease’s potential for infinite proliferation and a predilection for the head and neck. There is a lack of epidemiological reports on tufted angioma among Taiwanese and also a dearth of therapeutic guidelines. We retrospectively analyzed 45 histologically-confirmed cases (25 men, 20 women) of tufted angi ..................More
  Case Report
  Aquagenic Syringeal Acrokeratoderma
Hsing-Chuan Lee Tsen-Fang Tsai
Dermatol Sinica 26: 145-150, 2008

Aquagenic syringeal acrokeratoderma is a newly described disease entity of unclear etiology, affecting predominantly adolescents and young adults. It manifested as multiple whitish papules on the palms or rarely soles, which became accentuated after immersion in water and improved after drying the involved area. Burning, pain, pruritus or tightening sensation may be present and usually there is an association with palmar hyperhidrosis. The histopathology revealed dilated sweat duct ostia wi ..................More
  Keratitis, Ichthyosis and Deafness Syndrome-A Case Report and Literature Review
Chin-Ya Yang Yi-Ju Chen Jui-Lung Shen
Dermatol Sinica 26: 151-156, 2008

The acronym “KID syndrome” was proposed by Skinner et al. in 1981 to represent keratitis, ichthyosis and deafness. It is a rare syndrome and about 70 cases have been reported. Herein, we report a 28-year-old male with keratoderma, bilateral deafness, total blindness, alopecia and cerebellar hypoplasia. Our patient started to have walking difficulties at the age of 6 and is now bed-ridden. Several huge erythematous plaques with verrucous surface were noted over the lower limbs. Squamous ..................More
  Aplasia Cutis Congenita Associated with Cutis Marmorata Telangiectatica Congenita, Atrial Septal Defect, and Epilepsy: A Newly Recognized Syndrome?
Jeng-Feng Chen Shi-Chou Chen Chien-Ping Chiang
Dermatol Sinica 26: 157-164, 2008

Aplasia cutis congenita (ACC) is a rare developmental malformation characterized by the absence of skin, and often extends to bone or dura in a localized or widespread area at birth. ACC is seen most commonly on the scalp reported up to eighty-four percent of all cases in the literature. It often manifested as a solitary lesion without other anomalies, but sometimes represented as part of a heterogenous group of disorders. We presented a case of ACC associated with cutis marmorata telangiec ..................More
  Herpes Simplex Virus-Associated Recurrent Erythema Multiforme: The Implication of MHC Class Molecules on Susceptibility
Yu-Chi Chen Chung-Hsing Chang
Dermatol Sinica 26: 165-170, 2008

Erythema multiforme is an acute mucocutaneous hypersensitivity reaction caused by a variety of etiologies. Here we report a case of herpes simplex virus-associated recurrent erythema multiforme. This 21-year-old male presented with recurrent oral ulcers for more than 10 years. During the last two years, multiple erythematous to violaceous papules and plaques with a central vesicle over all four limbs had developed 10 to 14 days after the occurrence of oral ulcers. The patient’s blood test ..................More
  Bullous Pemphigoid with Esophageal Involvement Presenting as Exfoliative Esophagitis and Acute Upper Gastrointestinal Bleeding: Reports of Two Cases and Review of the Literature
Wei-Hsin Wu Chia-Yu Chu
Dermatol Sinica 26: 171-179, 2008

Bullous pemphigoid is the most common autoimmune blistering skin disease usually occurs in the elderly. The characteristic skin lesions present large and tense blisters arising on normal, erythematous, or urticarial bases and most commonly involve lower abdomen, inner thighs and flexural areas. The mucous membrane lesions occur in about 10 to 35 percent of patients and are almost limited to the oral mucous membrane. Esophageal involvement is a rare condition which may be completely asymptom ..................More
  Milia En Plaque - A Case Report
Li-Kai Lo Tsen-Fang Tsai Chih-Ming Hung Yu-Fu Chen Wang-Cheng Ko
Dermatol Sinica 26: 180-184, 2008

‘Milia en plaque’ is a rare disease entity with unclear pathogenesis but distinctive histopathology. No more than 30 cases have been recorded in the world’s literature. Most of them occurred in the peri-auricular area. There were no optimal treatments. We describe a 65-yearold man with a flesh-colored plaque embedded with tiny globoid cysts on his left cheek, which developed in one year. Combined its clinical and histopathological findings, we concluded it as milia en plaque and treat ..................More
  Resident Forum
  Multiple Painful Ulcers of a 42-year-old Man
Wei-Hsuan Huang Yeu-Chin Chen Chien-Ping Chiang
Dermatol Sinica 26: 185-186, 2008

A 42-year-old male suffered from multiple painful ulcers surrounding by raised, undermined borders over his face, trunk, and legs for 2 months (Fig. 1A, 1B). The skin lesions responded poorly to antibiotics. Laboratory examinations showed leukocytosis with monocytosis, anemia, and thrombocytopenia. A biopsy from the edge of one ulcer showed hemorrhagic necrosis and a dense infiltration of neutrophils extending throughout the dermis to the subcutis (Fig. 2). A chest X-ray showed several soft ..................More
  Multiple Vegetating Granulomatous Nodules in a 94-year-old Man
Yi-Chieh Lin Chien-Ping Chiang
Dermatol Sinica 26: 187-188, 2008

A 94-year-old male patient presented with multiple vegetating and granulomatous nodules on the right groin and gluteal region in the recent one year (Fig. 1A). He was robust before without any other systemic diseases except oral erosion developed one week before he visited our clinic. Tentative diagnosis included cutaneous fungal infection, cutaneous T cell lymphoma, and vegetating blistering disease. Bacterial and fungal culture showed no growth of microorganism. An incisional biopsy was p ..................More
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