Back issues No.2 - 2009  
  Recent Advances in Mast Cell Biology
Yoshiki Miyachi
Dermatol Sinica 27: 79-84, 2009

Mast cells (MCS) are not simple trouble makers in immediate allergic hypersensitivity, but play various important biological roles in host defense as well as tissue remodeling after infl ammation such as wound healing and fi brosis. Since heterogeneity exists in human MCS, human skin type MCS should be used for dermatological research. A large number of pure human skin type MCS which satisfy all characteristics of cutaneous MCS have been established from human dispersed skin in the absence ..................More
  Original Study
  Lipomatous Mixed Tumor of the Skin
Hung-Wei Lin, Han-Nan Liu
Dermatol Sinica 27: 85-92, 2009

Background: Mixed tumors of the skin showing extensive lipomatous change have been reported scantly in the literature. The cause of this change is under debate and have generally been attributed to metaplasia of the tumor cells or less commonly, lipomatous degeneration. Objective: This study was aimed to evaluate how often the lipomatous change happen in mixed tumors and attempt to elucidate the etiology of such changes via histopathological and immunohistiochemical methods. Methods: Cases ..................More
  Langerhans Cell Histiocytosis in Taiwan: A Retrospective Case Series in a Medical Center
Yi-Chin Shih, Wan-Lung Lin, I-Hsin Shih
Dermatol Sinica 27: 93-102, 2009

Background: Langerhans cell histiocytosis (LCH) comprises a diverse group of disorders where pathologic Langerhans cells accumulate in a variety of organs. Objectives: To characterize the disease presentation in Taiwanese, and to analyze the differences of LCH between Taiwanese and western populations. Methods: A retrospective chart review was performed on patients diagnosed with LCH in a medical center in Taiwan between 1990 and 2006. Results:􀀃􀀷􀁋􀁌И ..................More
  Case Report
  Bullous Prurigo Pigmentosa- A Case Report and Review of the Literature
Kun-Ying Tsai, Chien-Chun Chiou, Rosaline Chung-Yee Hui
Dermatol Sinica 27: 103-110, 2009

Prurigo pigmentosa is a type of inflammatory dermatosis characterized by symmetrical pruritic erythematous papules that normally resolve with reticular pigmentation. In severe cases, edematous infi ltrative plaques may be found, but usually no vesicles or bullae. We presented a 32-year-old Taiwanese female, a case of insulin dependent diabetis mellitus with sudden onset of vesicobullae upon erythematous papuloplaques over the face, neck and upper trunk, preceding an episode of diabetic keto ..................More
  Topical Steroid Induce Demodicidosis as a Presentation of Hemifacial Rosacea-Like Lesion
Yi-Ling Shih, Yu-Huei Huang, Hsin-Chun Ho, Chih-Hsun Yang
Dermatol Sinica 27: 111-116, 2009

Demodex mites share a commensal relationship with humans, and they asymptomatically parasitize the pilosebaceous follicles of humans. In healthy skin, the density of the mites is normally low, and this low density does not cause skin diseases. When the density of these mites increases, they induce facial skin diseases. We describe a 27-year-old male who presented in our outpatient department with a 10-year history of red and itchy skin lesions on the right side of his face. Determination of ..................More
  A Case of Rosacea Fulminans Responsive to Combination Treatment with Dapsone, Doxycycline and Topical Tacrolimus
Ta-Ju Liu, Chih-Sheng Lai, Wen-Chieh Chen, Yu-Wen Chang
Dermatol Sinica 27: 117-121, 2009

Rosacea fulminans is a rare variant of rosacea characterized by sudden onset of papules, pustules, and coalescing nodules on the face in postadolescent women. A combination regimen including systemic isotretinoin and oral plus topical potent corticosteroids is the recommended therapy. We report a case of rosacea fulminans in Taiwan in a 48-year-old woman who still had persistent facial erythema and continually active papulopustules after initiation of the conventional therapy for 3 months. ..................More
  Acrodermatitis Acidemica Associated with Defi ciency of Branched Chain Amino Acids in Maple Syrup Urine Disease-A Case Report and Review of the Literature
Ching-Yin Chen, Tien-Yi Tzung, Chieh-Shan Wu, Ya-Hui Chen
Dermatol Sinica 27: 122-127, 2009

Acrodermatitis acidemica is a form of various enzyme defects involving the metabolism of branched-chain amino acids (BCAAs) along with cutaneous features reminiscent of acrodermatitis enteropathica. We report a case of acrodermatitis acidemica associated with a defi ciency of BCAAs in maple syrup urine disease. This 2-month-old 4402-gram in weight Paiwanese boy, an aboriginal Taiwanese, was diagnosed as having maple syrup urine disease by severe diarrhea being the main determining factor. A ..................More
  Successful Treatment of Topical Tretinoin Cream in a Patient with Unilateral Nevoid Hyperkeratosis of Nipple and Areola
Kun-Ying Tsai, Hsiu-Cheng Hsu
Dermatol Sinica 27: 128-131, 2009

A 53-year-old man presented with a 20- year history of asymptomatic, progressive pigmented thickening of his left nipple and areola. He denied having any chronic illness. However, a diagnosis of glioblastoma multiforme had recently been made, and he had received three years of combination therapies, including subtotal excision, radiotherapy, chemotherapy, and photodynamic therapy, without any documented subsequent endocrine abnormality. ..................More
  Acitretin Use in Epidermal Nevus Syndrome
Erick Chern, Ji-Chen Ho, Wei-Ming Wu
Dermatol Sinica 27: 132-135, 2009

A 24-year-old girl presented with linear verrucous skin lesions since birth. Patient also had a history of neonatal seizure and cataract operation at the age of 3 month old. Patient was the product of a full-term uncomplicated pregnancy and delivery; her birth history was uneventful with no traumatic injury or hypoxia. ..................More
  Resident Forum
  A Solitary Facial Nodule of a 48-year-old Man
Yu-Tzu Tai, Horng-Shin Lin, Yu-Ping Hsiao, Han Chang, Jen-Hung Yang
Dermatol Sinica 27: 136-137, 2009

A 48-year-old man presented with a reddish skin tumor over face for three months. He denied any systemic disease and history of insect bite. The skin examination revealed a reddish dome-shaped elastic fi rm nodule, 1.2 cm in diameter, over left zygomatic area (Fig. 1). Other physical exam did not show any abnormal findings such as lymphadenopathy or hepatosplenomegaly. The nodule was partially excised for pathological examination. The histopathology revealed superficial and deep patches of ..................More
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