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Vascular Tumors of Intermediate Malignancy:A Review and Update
Jason S. Stratton, Steven D. Billings
Dermatol Sinica 27: 140-153, 2009
Vascular tumors of intermediate malignancy encompass a broad range of histologic entities.
They are characterized clinically by having a high risk of local recurrence and limited risk of
regional or distant metastasis. Vascular tumors of intermediate malignancy frequently present in
the skin and often cause diagnostic diffi culty. This article reviews the clinical and histologic features
of kaposiform hemangioendothelioma, epithelioid hemangioendothelioma, Dabska tumor,
retiform hemangioend ..................More |
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Differentiating Basal Cell Carcinoma from Trichoepithelioma by Using Androgen Receptor Expression
Yu-Fen Lee, Yun-Ting Chang, Han-Nan Liu
Dermatol Sinica 27: 154-160, 2009
Background: To distinguish a basal cell carcinoma (BCC) from a trichoepithelioma (TE) can be
diffi cult even for an experienced dermatopathologist.
Objective: In this study, we sought to reconfi rm the androgen receptors (AR) immunostaining
pattern of BCC and TE and to determine whether AR immunoreactivity could serve as a useful
maker to differentiate these two tumors.
Methods: Twenty-one cases of circumscribed BCC, solid type and nineteen cases of TE were
obtained from the fi les of the ..................More |
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Inconsistent Immunostaining and Racial Difference in Extramammary Paget’s Disease
Fu-Chiang Chiang, Szu-Ying Chu, Yun-Ting Chang
Dermatol Sinica 27: 161-169, 2009
Background: Extramammary Paget’s disease (EMPD), an uncommon neoplastic disorder, usually
presents as an eczematous patch on the apocrine-rich area. It can be further classifi ed into
primary and secondary EMPD by its association with underlying malignancies. The histopathology
shows a characteristic intraepidermal atypical clear cell infi ltrate.
Objective: To determine whether the histopathologic or immunohistochemical features of EMPD
could be used to predict clinical behavior or assoc ..................More |
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Application of Allele-Specifi c Polymerase Chain Reaction for Rapid Differentiation of Mycobacterium Leprae from Mycobacterium Tuberculosis
Yu-Ta Yen, Yu-Wen Cheng, Wei-Ming Wu
Dermatol Sinica 27: 170-175, 2009
Leprosy (Hansen’s disease) is a chronic granulomatous infection caused by Mycobacterium
leprae affecting primarily skin and nerves. Leprosy is an important clinical problem and is also a
challenging diagnostic problem for clinicians. Clinically, leprosy might at times be diffi cult to be
distinguished from lupus vulgaris. We report a 70-year-old woman who showed a well-demarcated
erythematous enlarging plaque on left peri-ocular region suggesting leprosy resembling lupus
vulgaris. Skin bi ..................More |
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Langerhans Cell Histiocytosis Presented as Generalized Vesiculo-Pustules in a Neonate
Yu-Fen Lee, Ding-Dar Lee, Han-Nan Liu
Dermatol Sinica 27: 176-180, 2009
A one-month-old female baby had been noted to have multiple vesicles and pustules over
the head, face, trunk and four extremities since she was one-week-old. Under the impression of
disseminated herpes virus infection, intravenous acyclovir was given after admission. Serum herpes
simplex virus and varicella zoster virus enzyme-linked immunosorbent assay test and virus
culture were all fruitless, although herpes simplex virus-1 was vaguely identifi ed in direct fl uorescent
staining of lesio ..................More |
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A Solitary Halo Neurofi broma
Ming-Ya Mao, Meng-Tse Wu, Hsu-Jung Hsieh, Tze-Yi Lin, Po-Yuan Wu
Dermatol Sinica 27: 181-185, 2009
Halo neurofi broma is a rare benign tumor. In the past, 3 cases of multiple halo neurofi bromas
and 1 case of a solitary halo neurofi broma have been reported. The neurofi broma is characterized
by a skin-colored, dome-shaped soft papule or a nodule surrounded by hypopigmented
macules. The pathogenesis of neuroectodermally derived tumors associated with halo phenomenon
is still poorly understood. We report a case of a 46-year-old female with a solitary halo neurofi
broma and discuss the pos ..................More |
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Two Cases of Multiple Eccrine Hidrocystomas with Good Response to Botulinum Toxin
Ta-Ju Liu, Ji-Chen Ho
Dermatol Sinica 27: 186-191, 2009
Multiple eccrine hidrocystomas of the face are rare benign cystic lesions characterized
by numerous asymptomatic, fl esh-colored, mild, and translucent facial papules in middle-aged
women. The condition often runs a chronic course, which may be exacerbated by seasonal
change or heat exposure. Topical application of 1% atropine is the conventional treatment option,
but the results are not always satisfying. Here, we present the clinicopathological features of and
treatment modality for two m ..................More |
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Photo-Induced Sarcoidosis
Yu-Ping Hsiao, Han Chang, Meng-Chuan Ho, Lien-Chuan Yang,, Jen-Hung Yang
Dermatol Sinica 27: 192-195, 2009
A 61-year-old woman, who was a
farmer, suffered from fl esh to reddish annular
skin rash over face, trunk and the extremities
on and off for more than 20 years. The eruptions
initially occurred on the face, and then
involved the neck, chest, upper back and
dorsal aspects of upper limbs indicating sunexposed
areas. The lesions revealed as annular,
erythematous, shiny-surfaced, infi ltrated
papules or plaques (Fig. 1). The physical examination
revealed no abnormal fi ndings on
chest, an ..................More |
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Detection of Human Papillomavirus Type 31 in a Case of Papillated Bowen’s Disease
Jeng-Feng Chen, Bai-Yao Wu
Dermatol Sinica 27: 196-198, 2009
A 74-year-old male visited our clinic
because of an asymptomatic skin lesion on
the inner aspect of left thigh, which he had
noticed for one year. He denied any history
of arsenic ingestion, immunosuppressive
therapy or radiotherapy. Past history was unremarkable.
There are no lesions suspicious
for human papillomavirus (HPV) infection
during whole body skin examination. His
wife was recently under gynecologic and
dermatologic check-up and there is no evidence
suggestive of HPV infect ..................More |
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A Painless Mass on the Upper Arm
Shih-Wei Yeh, Kuo-Hsien Wang, Chung-Hong Hu, Woan-Ruoh Lee, Hsiou-Hsin Tsai
Dermatol Sinica 27: 199-200, 2009
A 92-year-old male patient presented with a 3-year history of an enlarging, painless mass
on the right arm (Fig. 1). He did not have any history of trauma on the area. The patient reported
no weight loss and had no other symptoms other than rapid enlarging of the tumor for the last 6
months. Physical examination showed an 8 x 5 cm fl esh colored, fi rm, ill-defi ned mass on right
arm (Fig. 1). No cervical or axillary lymphadenopathy was noted. The MRI showed a huge illdefi
ned soft tissue m ..................More |
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