Back issues No.4 - 2009  
  Severe Cutaneous Adverse Reactions to Drugs (SCAR):Defi nitions, Diagnostic Criteria, Genetic Predisposition
Jean-Claude Roujeau, Laurence Allanore, Yvonne Liss, Maja Mockenhaupt
Dermatol Sinica 27: 203-209, 2009

This paper is a review of the clinical characteristics, diagnostic criteria and main drug causes of the severe cutaneous adverse reactions to drugs (SCAR) that are studied by the RegiSCAR- group. These include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (also called drug-induced hypersensitivity syndrome), Stevens- Johnson syndrome, and toxic epidermal necrolysis. ..................More
  Original Study
  Attitudes and Practices Regarding Nose Piercing:Results of a Questionnaire Survey and Review of the Literature
Cemal Cingi, Murat Songu, Can Cemal Cingi, Hamdi Cakli, Onder Ihvan
Dermatol Sinica 27: 210-217, 2009

Background: Body piercing confi ned to the ears, mouth, and nose has been a common practice in almost every society around the world as far back as can be traced. As the popularity of piercing increasing, there is a soaring urgency of understanding the subsequent complications. Objective: A survey was designed to analyze the attitudes and practices of a group of volunteers wearing nose piercing. The questionnaire aimed to establish where and how the individuals had their piercing and what k ..................More
  Ichthyosiform Irritant Contact Dermatitis Caused by Antiseptics for Personal Hygiene
Yi-Pei Lee, Julia Yu-Yun Lee
Dermatol Sinica 27: 218-226,2009

Background: Antiseptics are commonly used for personal hygiene in Taiwan. We have previously reported a series of ichthyosiform irritant contact dermatitis induced by cetrimide-containing antiseptics. Objectives: To report a new series of antiseptics-induced ichthyosiform irritant contact dermatitis and bring attention to the potential irritation effects of antiseptics. Methods: We reviewed the clinicopathologic features of cases of cetrimide dermatitis, Savlon dermatitis or ichthyosiform ..................More
  Case Report
  Congenital Malignant Rhabdoid Tumor of the Skin-Report of A Case and Review of the Literature
Chin-Yi Yang, I-Hsin Shih, Tseng-Tong Kuo, Chih-Hsun Yang, Cheng-Shiang Shiao
Dermatol Sinica 27:227-234, 2009

Malignant rhabdoid tumor is a well-established clinicopathologic entity occurring classically in the kidney and central nervous system in children. Cutaneous origin has rarely been reported. We herein report a male newborn infant presented with an erythematous and ulcerated mass on his lower back at birth and was found to be a malignant rhabdoid tumor, diagnosed by histopathologic and immunohistochemical studies. In spite of aggressive treatment with chemotherapy and surgery, cerebral and p ..................More
  Rosuvastatin-Induced Thrombocytopenic Purpura-A Case Report
Zheng-Wei Lin, Hsin-Chun Ho, Chih-Hsun Yang, Rosaline Chung-Yee Hui, Wen-Hung Chung
Dermatol Sinica 27: 235-240, 2009

Many medications can cause thrombocytopenic purpura, including some hypolipidemic agents. This is the fi rst case report of thrombocytopenic purpura due to the 3-hydroxy-3-methylglutaryl- coenzyme A reductase inhibitor, rosuvastatin. A 57-year-old Asian man developed multiple petechiae and purpura one month after receiving rosuvastatin in a dosage of 20 mg/day. When the drug was stopped and the patient was treated with systemic methylprednisolone, 24 mg/day, his symptoms cleared within 4 we ..................More
  Graft-Versus-Host-Like Disease- A Case of Thymoma-Related Erythroderma
Yu-Ta Yen, Ji-Chen Ho, Cheng-Yu Wang
Dermatol Sinica 27: 241-247,2009

Graft-versus-host disease (GVHD) is a T-cell-mediated reaction that most commonly develops after transplantation of hematopoietic stem cells. In rare conditions, GVHD-like symptoms are observed in patients with thymoma. We present the case of a 58-year-old man with thymoma noted 6 years earlier who initially presented with myasthenia gravis and subsequently developed GVHD-like disease with symptoms of generalized itching, scaly erythroderma, and liver dysfunction. The histopathological feat ..................More
  Generalized Edema and Telangiectasia: Unusual Presentation of Intravascular Large B-cell Lymphoma
Chia-Mao Kao, Ying-Jui Chang, Cheng-Hsiang Hsiao, Yu-Ling Hsu, Ping-Huai Wang, Tsung-Hua Tsai, Lin-Hui Su
Dermatol Sinica 27: 248-253, 2009

Intravascular large B-cell lymphoma is characterized by clusters of large neoplastic B cells within small blood vessels, most commonly in the dermis and subcutis. There is no nodal or parenchymal involvement until late in the disease, and its endothelial tropism is responsible for the variable clinical features. We report the case of a 51 year-old man who presented with fever, altered mental status, generalized edema, and profound telangiectasia. The diagnosis was made by a skin biopsy from ..................More
  Trichilemmal Keratosis Manifesting as a Cutaneous Horn
Feng-Ling Lin, Che-Hao Hsu
Dermatol Sinica 27: 254-256, 2009

CASE REPORT A 45-year-old man presented with an asymptomatic, slowly growing, keratotic nodule on his left fl ank for one year. Physical examination revealed a pea-sized, horn-like plaque protruding from a brownish nodule (Fig. 1 A, B). The tumor had been present for years as a cyst-like lesion before, but the tumor ruptured 1 year before this consultation. Later, a horn-like structure developed on the center of it. The lesion was excised en bloc under the impression of keratoacanthom ..................More
  Progressive Neurologic Abnormalities in a Woman with Phakomatosis Pigmentovascularis Type V
Po-Hsuan Lu, Mei-Eng Tu, Yu-Hung Wu
Dermatol Sinica 27: 257-259, 2009

CASE REPORT A 28-year-old woman with extensive skin lesions since birth presented with the acute onset three months previously of slurred speech, diffi culty swallowing, numbness of her left face, and right-sided weakness. She had been quite well during the elementary school years, but in her early teens, she began stumbling and falling and her walking slowed. At the age of 21, she lost the vision in her left eye because of glaucoma. She denied a history of muscle pain, headache, diz ..................More
  Resident Forum
  An Intriguing Subcutaneous Nodule on Right Upper Arm
Szu-Ying Chu, Chang-Lin Chen, Ding-Dar Lee
Dermatol Sinica 27: 260-261, 2009

CASE REPORT A 49-year-old female noticed a deep-seated nodule with rubbery consistency on right upper arm for 2 months. Erythematous change on surface was seen (Fig. 1). She was suffered from mild itching sensation without pain or tenderness. The lesion progressed in size gradually. She visited our hospital for help and excisional biopsy was performed. Histologically, a well-defi ned nodule circumscribed by eosinophilic cuticle was found in subcutaneous tissue. The wall of nodule consisted ..................More
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