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Severe Cutaneous Adverse Reactions to Drugs (SCAR):Defi nitions, Diagnostic Criteria, Genetic Predisposition
Jean-Claude Roujeau, Laurence Allanore, Yvonne Liss, Maja Mockenhaupt
Dermatol Sinica 27: 203-209, 2009
This paper is a review of the clinical characteristics, diagnostic criteria and main drug
causes of the severe cutaneous adverse reactions to drugs (SCAR) that are studied by the RegiSCAR-
group. These include acute generalized exanthematous pustulosis, drug reaction with
eosinophilia and systemic symptoms (also called drug-induced hypersensitivity syndrome), Stevens-
Johnson syndrome, and toxic epidermal necrolysis. ..................More |
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Attitudes and Practices Regarding Nose Piercing:Results of a Questionnaire Survey and Review of the Literature
Cemal Cingi, Murat Songu, Can Cemal Cingi, Hamdi Cakli, Onder Ihvan
Dermatol Sinica 27: 210-217, 2009
Background: Body piercing confi ned to the ears, mouth, and nose has been a common practice
in almost every society around the world as far back as can be traced. As the popularity of piercing
increasing, there is a soaring urgency of understanding the subsequent complications.
Objective: A survey was designed to analyze the attitudes and practices of a group of volunteers
wearing nose piercing. The questionnaire aimed to establish where and how the individuals had
their piercing and what k ..................More |
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Ichthyosiform Irritant Contact Dermatitis Caused by Antiseptics for Personal Hygiene
Yi-Pei Lee, Julia Yu-Yun Lee
Dermatol Sinica 27: 218-226,2009
Background: Antiseptics are commonly used for personal hygiene in Taiwan. We have previously
reported a series of ichthyosiform irritant contact dermatitis induced by cetrimide-containing
antiseptics.
Objectives: To report a new series of antiseptics-induced ichthyosiform irritant contact dermatitis
and bring attention to the potential irritation effects of antiseptics.
Methods: We reviewed the clinicopathologic features of cases of cetrimide dermatitis, Savlon
dermatitis or ichthyosiform ..................More |
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Congenital Malignant Rhabdoid Tumor of the Skin-Report of A Case and Review of the Literature
Chin-Yi Yang, I-Hsin Shih, Tseng-Tong Kuo, Chih-Hsun Yang, Cheng-Shiang Shiao
Dermatol Sinica 27:227-234, 2009
Malignant rhabdoid tumor is a well-established clinicopathologic entity occurring classically
in the kidney and central nervous system in children. Cutaneous origin has rarely been
reported. We herein report a male newborn infant presented with an erythematous and ulcerated
mass on his lower back at birth and was found to be a malignant rhabdoid tumor, diagnosed by
histopathologic and immunohistochemical studies. In spite of aggressive treatment with chemotherapy
and surgery, cerebral and p ..................More |
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Rosuvastatin-Induced Thrombocytopenic Purpura-A Case Report
Zheng-Wei Lin, Hsin-Chun Ho, Chih-Hsun Yang, Rosaline Chung-Yee Hui, Wen-Hung Chung
Dermatol Sinica 27: 235-240, 2009
Many medications can cause thrombocytopenic purpura, including some hypolipidemic
agents. This is the fi rst case report of thrombocytopenic purpura due to the 3-hydroxy-3-methylglutaryl-
coenzyme A reductase inhibitor, rosuvastatin. A 57-year-old Asian man developed
multiple petechiae and purpura one month after receiving rosuvastatin in a dosage of 20 mg/day.
When the drug was stopped and the patient was treated with systemic methylprednisolone, 24
mg/day, his symptoms cleared within 4 we ..................More |
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Graft-Versus-Host-Like Disease- A Case of Thymoma-Related Erythroderma
Yu-Ta Yen, Ji-Chen Ho, Cheng-Yu Wang
Dermatol Sinica 27: 241-247,2009
Graft-versus-host disease (GVHD) is a T-cell-mediated reaction that most commonly develops
after transplantation of hematopoietic stem cells. In rare conditions, GVHD-like symptoms
are observed in patients with thymoma. We present the case of a 58-year-old man with thymoma
noted 6 years earlier who initially presented with myasthenia gravis and subsequently developed
GVHD-like disease with symptoms of generalized itching, scaly erythroderma, and liver
dysfunction. The histopathological feat ..................More |
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Generalized Edema and Telangiectasia: Unusual Presentation of Intravascular Large B-cell Lymphoma
Chia-Mao Kao, Ying-Jui Chang, Cheng-Hsiang Hsiao, Yu-Ling Hsu, Ping-Huai Wang, Tsung-Hua Tsai, Lin-Hui Su
Dermatol Sinica 27: 248-253, 2009
Intravascular large B-cell lymphoma is characterized by clusters of large neoplastic B cells
within small blood vessels, most commonly in the dermis and subcutis. There is no nodal or
parenchymal involvement until late in the disease, and its endothelial tropism is responsible for
the variable clinical features. We report the case of a 51 year-old man who presented with fever,
altered mental status, generalized edema, and profound telangiectasia. The diagnosis was made
by a skin biopsy from ..................More |
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Trichilemmal Keratosis Manifesting as a Cutaneous Horn
Feng-Ling Lin, Che-Hao Hsu
Dermatol Sinica 27: 254-256, 2009
CASE REPORT
A 45-year-old man presented with an
asymptomatic, slowly growing, keratotic
nodule on his left fl ank for one year. Physical
examination revealed a pea-sized, horn-like
plaque protruding from a brownish nodule
(Fig. 1 A, B). The tumor had been present for
years as a cyst-like lesion before, but the tumor
ruptured 1 year before this consultation.
Later, a horn-like structure developed on the
center of it. The lesion was excised en bloc
under the impression of keratoacanthom ..................More |
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Progressive Neurologic Abnormalities in a Woman with Phakomatosis Pigmentovascularis Type V
Po-Hsuan Lu, Mei-Eng Tu, Yu-Hung Wu
Dermatol Sinica 27: 257-259, 2009
CASE REPORT
A 28-year-old woman with extensive
skin lesions since birth presented with
the acute onset three months previously of
slurred speech, diffi culty swallowing, numbness
of her left face, and right-sided weakness.
She had been quite well during the elementary
school years, but in her early teens,
she began stumbling and falling and her
walking slowed. At the age of 21, she lost the
vision in her left eye because of glaucoma.
She denied a history of muscle pain, headache,
diz ..................More |
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An Intriguing Subcutaneous Nodule on Right Upper Arm
Szu-Ying Chu, Chang-Lin Chen, Ding-Dar Lee
Dermatol Sinica 27: 260-261, 2009
CASE REPORT
A 49-year-old female noticed a deep-seated nodule with rubbery consistency on right upper
arm for 2 months. Erythematous change on surface was seen (Fig. 1). She was suffered from
mild itching sensation without pain or tenderness. The lesion progressed in size gradually. She
visited our hospital for help and excisional biopsy was performed. Histologically, a well-defi ned
nodule circumscribed by eosinophilic cuticle was found in subcutaneous tissue. The wall of
nodule consisted ..................More |
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