Back issues No.2 - 2010  
  Biology of melanogenesis and the search for hypopigmenting agents
Kyoung-Chan Park, Sun Young Huh, Hye Ryung Choi, Dong-Seok Kim

Increased production and accumulation of melanin are characteristics of a large number of skin diseases, including melasma, post-inflammatory hyperpigmentation and lentigo. A number of clinical agents can reduce normal or abnormal pigmentation, but none of these have achieved satisfactory effects. This review discusses the mechanisms behind the different approaches. Tyrosinase is a pivotal enzyme in melanin synthesis. The majority of whitening or lightening agents act by specifically reduci ..................More
  Original Study
  Mutation analysis of the ATP2C1 gene in Taiwanese patients with Hailey-Hailey disease
Meng-Chi Wu, Yi-Chen Liao, Sheau-Chiou Chao

Background Hailey-Hailey disease (HHD) is an autosomal dominant disorder with recurrent pruritic vesicles and erosions, and scaly erythematous plaques, particularly involving intertriginous areas such as the neck, axillae, groins and perineum. Histopathology shows intraepidermal vesiculation with acantholysis in the suprabasal layer. It is caused by heterozygous mutations in the ATP2C1 gene, which encodes for the human secretory pathway Ca2+/Mn2+ ATPase 1. In this study, we analyze the muta ..................More
  Clinical and dermoscopic features of congenital melanocytic nevi
Murat Orhan Oztas

Background Congenital melanocytic nevi (CMN) are nevomelanocytic nevi which are present at birth. In this study, we set out to determine the clinical and dermoscopic properties of CMN. Methods A total of 239 lesions were diagnosed as CMN. Dermoscopic properties were noted. Age, sex, nevus location and nevus size of the patients were also collected from the patient records. Results A total of 239 lesions were diagnosed as CMN in 239 patients (age ranged from 1 month to 63 years (20.79 ± 1 ..................More
  Brief Report
  Exanthem of measles and clues to its diagnosis: experience of a nosocomial outbreak in Taiwan
Fang-Wen Tseng, Yhu-Chering Huang, Su-Chin Shen, I-Hsin Shih, Chih-Hsun Yang, Hsiu-Cheng Hsu

Taiwan has been experiencing a resurgence of measles since the beginning of 2009. We retrospectively reviewed the clinical presentations of eight confirmed measles cases during a nosocomial outbreak, in order to identify diagnostic clues. The exanthem was polymorphous and non-specific in terms of its morphology, distribution, sequence of appearance, and symptoms. The presence of cough and coryza as well as abnormal results of routine laboratory studies were also non-specific and unhelpful f ..................More
  Case Report
  Panfolliculoma: report of two cases
Ching-Yu Huang, Yu-Hung Wu

Panfolliculoma is a distinctive and unusual benign follicular neoplasm. It shows differentiation towards all components of the hair follicle, including the upper and the lower segments. We report two cases of this rare disease. The first patient presented with a painful nodule on the scalp and the second patient had an asymptomatic skin-colored nodule on his left eyebrow. Histopathologic examination of both cases revealed lobular proliferation of solid-cystic follicular structures. The cyst ..................More
  Granulomatous pigmented purpuric dermatoses: report of three cases and review of the literature
Jen-Yu Wang, Yu-Hung Wu, Pa-Fan Hsiao, Chi-Fu Kao

Purpuric pigmented dermatoses represent a form of chronic, recurrent capillaritis characterized by petechiae and purpuric macules over the lower limbs. We report three female cases who presented with clinical features of purpuric pigmented dermatosis with unusual histopathologic features. The first patient had golden-brown pigmented purpura over bilateral knees, shins and dorsal feet. The second patient showed purpuric papules on the medial aspects of the ankles. The third patient presented ..................More
  Long-term control of refractory Schnitzler syndrome with anakinra: a case report
Hsien-Yi Chiu, Tsen-Fang Tsai

Schnitzler syndrome is a rare inflammatory disorder characterized by chronic urticarial rash, monoclonal gammopathy, periodic fever, arthralgia/arthritis and bone pain. However, the results of management of Schnitzler syndrome are often disappointing and its treatment remains a challenge. No cases of spontaneous complete remission have been reported. Anakinra is an interleukin 1 receptor antagonist used for the treatment of rheumatoid arthritis, and has been reported to be universally effec ..................More
  Pincer nail deformity associated with an arteriovenous fistula for hemodialysis
Yun-Ting Su, Julia Yu-Yun Lee

A 51-year-old female piano teacher presented with a 3-month history of progressive deformity of the nails of the right hand, associated with painful erythematous swelling of the lateral nail folds. Her medical history was significant for hypertension, hyperlipidemia, diabetes mellitus and end-stage renal disease. She had been undergoing hemodialysis for the past 8 years. She was taking nifedipine, valsartan, doxazosin and fluvastatin. The patient noticed progressive thickening and increa ..................More
  Resident Forum
  Papulopustular eruptions of bilateral soles with facial erythematous papuloplaques in a 44-year-old female
Chih-Hsiang Chang, Kun-Ying Tsai, Li-Cheng Yang

A 44-year-old female suffered from chronic recurrent papules, vesicles and pustules on bilateral soles and heels for more than 1 year. It was associated with painful and itchy sensation. She had been treated as having pompholyx at a local hospital. The lesions improved partially but soon flared up after discontinuing the treatment. This time, she suffered from erythematous papuloplaques on bilateral cheeks and forehead with itchy sensation and mild tenderness for 4 months (Figure 1). Laborat ..................More
  Multiple flesh-colored papules on the waist and multiple purpuric nodules on the tongue
Chia-Hung Wei, Wen-Yu Chuang, Chung-Chih Tang, Rosaline Chung-Yee Hui

An 83-year-old man presented with a 1-month history of multiple flesh-colored waxy papules over his bilateral waist, and bilateral inguinal and suprapubic areas. He had also noted multiple blister-like nodules over his buccal mucosa and various-sized purpuric tumors on his tongue for over a year. Both types of lesions were asymptomatic. His medical history included hypertension, chronic renal insufficiency, and previous cerebrovascular accident, and he was regularly followed up at our ho ..................More
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