Back issues No.3 - 2010  
  Xeroderma pigmentosum: clues to understanding cancer initiation
Hamid Reza Rezvani, Frédéric Mazurier, Fanny Morice-Picard, Thomas Jouary, Muriel Cario-André, Cécile Ged, Hubert de Verneuil, Alain Taïeb

Xeroderma pigmentosum (XP) type C is a rare autosomal recessive disorder that occurs because of inactivation of the xeroderma pigmentosum group C (XPC) protein, which is an important DNA damage recognition protein involved in DNA nucleotide excision repair (NER). This defect, which prevents removal of a wide array of direct and indirect DNA lesions, is associated with a decrease in catalase activity. As a novel photoprotective approach, lentivirus-mediated catalase overexpression in XPC hum ..................More
  Original Study
  Bacteriological examination of inflamed epidermal cysts: a survey between 2008 and 2009 at a hospital in southern Taiwan
Yen-Hsi Liu, Yu-Ta Yen, Ta-Ju Liu, Yi-Chien Yang, Cheng-Yu Wang, Wei-Ming Wu, Ji-Chen Ho, Yu-Wen Cheng
DERMATOLOGICA SINICA 28 (2010) 102–106

Background Inflamed epidermal cysts are common clinical conditions, and they frequently form abscesses. We designed a study to delineate the bacteriology of inflamed epidermal cysts. Methods We enrolled 61 adult patients with inflamed epidermal cysts characterized by surface erythema, with or without tenderness, or localized abscess formation within the cyst cavity. Incision and drainage of the cysts were performed, and the contents were sent for aerobic and anaerobic bacterial culture. Th ..................More
  Neonatal lupus erythematosus infants and their mothers: a 10-year retrospective study
Chin-Yi Yang, I-Hsin Shih, Chih-Hsun Yang
DERMATOLOGICA SINICA 28 (2010) 107–112

Background Neonatal lupus erythematosus (NLE) is a rare disease associated with transplacental transfer of maternal anti-Ro/anti-Sjögren syndrome A antibodies. The most common manifestations are cutaneous erythema and congenital heart block. Mothers of infants with NLE are either asymptomatic or diagnosed with autoimmune disease. The goal of this study is to investigate the clinical manifestation, prognosis, and association with autoimmune disease in NLE babies and their mothers in Tai ..................More
  Case Report
  Morphea-like localized involutional lipoatrophy—a case report associated with family history
Cheng-Huang Chang, Kan-Tang Fang, Song-Jen Hong
DERMATOLOGICA SINICA 28 (2010) 113–116

Localized involutional lipoatrophy is a rare, sporadic disease with female tendency and characterized by focal loss of adipose tissue. We report two sisters, aged 8 years and 6 years, who developed asymptomatic depressive areas on the upper left arm and upper right arm, respectively. Cutaneous sonography showed slight thickening of the dermis and remarkably decreased thickness of the cutaneous fat tissue. Histopathology of a biopsy specimen from the elder sister revealed an increase in homo ..................More
  Plexiform fibrohistiocytic tumor—report of one case with regional lymph node metastasis
Yi-Chun Chen, Cheng-Hsiang Hsiao, Jau-Shiuh Chen, Yi-Hua Liao
DERMATOLOGICA SINICA 28 (2010) 117–120

A plexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm primarily occurring in children and young adults. PFTs have been classified as fibrohistiocytic tumors of intermediate malignancy because of the high local recurrence rate and possible lymph node and distant metastasis. Histologically, PFTs are poorly demarcated dermal-to-subcutaneous tumors composed of small nodules or cellular clusters with a characteristic plexiform arrangement. We report a 17-year-old girl presentin ..................More
  Brachioradial pruritus in a young man presenting with transverse myelitis
Jui-Hung Ko, Po-Yu Shih, Yu-Huei Huang
DERMATOLOGICA SINICA 28 (2010) 121–124

Pruritus with unknown origin is a common complaint and secondary causes should be investigated. We report a 22-year-old man with intractable localized pruritus and painful burning, stinging sensations in the bilateral arms, shoulders, neck and upper back for 3 weeks. A dermatologist was consulted in the emergency department. On physical examination, there were multiple excoriated erythematous macules and depigmented scars in a linear distribution over the dermatome from C4 to C6. Decreased ..................More
  Necrobiotic xanthogranuloma with paraproteinemia without periorbital involvement—a case report
Chin-Yi Yang, Wen-Hung Chung, Rosaline Chung-Yee Hui, Tseng-Tong Kuo, Chih-Hsun Yang
DERMATOLOGICA SINICA 28 (2010) 125–129

Necrobiotic xanthogranuloma is an uncommon granulomatous disease involving the skin and extracutaneous tissues. It is characterized by indurated, yellow-red plaques and nodules, involving primarily the face and less frequently the trunk and extremities. The disease has a strong association with paraproteinemia and other hematologic or lymphoproliferative disorders. Histologically, the dermal part shows xanthogranulomatous change with extensive necrobiosis and many Touton and foreign-body gi ..................More
  Spontaneous resolution of recalcitrant generalized prurigo nodularis after resection of an ampulla of Vater tumor
Yun-Ting Su, Julia Yu-Yun Lee, Tak-Wah Wong
DERMATOLOGICA SINICA 28 (2010) 130–132

A 63-year-old retired male teacher presented with generalized pruritic papules for 4 years. The prurigo was recalcitrant to treatment and he was admitted for further evaluation and treatment. His medical history was significant for thyroidectomy for hyperthyroidism 23 years ago with normal thyroid function after surgery. He had hyperuricemia with gouty arthritis but received no treatment. He also complained of epigastric discomfort for several decades. He denied any history of atopy or d ..................More
  Resident Forum
  A fusiform nodule on the flank
Lu-An Chen, Ying-Jui Chang, Lin-Hui Su, Yu-Ling Hsu, Tsung-Hua Tsai
DERMATOLOGICA SINICA 28 (2010) 133–134

An otherwise healthy 61-year-old female presented with a skin tumor on the left flank, which had been present since her early adulthood. The tumor gradually enlarged during the first 2–3 years and then stabilized in size. There were no symptoms from the tumor. On examination, a red to violaceous, shiny, polypoid, fusiform nodule with firm consis tency, measuring approximately 3.0 cm × 2.0 cm, was noted on her left flank (Figure 1). There were also many skin tumors on her face and scalp, m ..................More
  Multiple mobile and firm subcutaneous nodules on bilateral shins
Shang-Hong Lin, Ji-Chen Ho, Wei-Ming Wu
DERMATOLOGICA SINICA 28 (2010) 135–136

A 40-year-old woman presented with a 10-year history of multiple subcutaneous nodules on the lower extremities. The first subcutaneous nodule occurred on the left shin, and over the last year, had increased in number and spread to the proximal extremities. The general condition of the patient was otherwise healthy, except that she was diagnosed with descending colon cancer and underwent surgery 2 years ago. A physical examination revealed mobile, firm, subcutaneous and asymptomatic nodules s ..................More
  A case of multiple deep and necrotic ulcers on the face
Tsai-Ching Chou, Ching-Ying Wu, Cheng-Che E. Lan
DERMATOLOGICA SINICA 28 (2010) 137–138

A 31-year-old male presented with painful facial ulcers over bilateral cheeks and the forehead for the past 2 weeks (Figure 1). Recent contact history included superficial chemical peeling with glycolic acid and self-squeezing of his cystic acne. The ulcers were shallow, clean and had a relatively broad base, with particular lesions over the left face arranged in a bizarre linear pattern. Self-induced pyoderma was suspected. However, the ulcers did not improve with antibiotic treatment. One ..................More
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