Back issues No.4 - 2010  
  Management of hair loss diseases
Manabu Ohyama
DERMATOLOGICA SINICA 28 (2010) 139–145

The treatment of hair loss diseases is sometimes difficult because of insufficient efficacy and limited options. However, recent advances in understanding of the pathophysiology and development of new remedies have improved the treatment of refractory hair loss conditions. In this article, an update on the management of hair loss diseases is provided, especially focusing on recently reported therapeutic approaches for alopecia areata (AA). An accurate diagnosis is indispensable to optimize ..................More
  Original Study
  Chemokine receptor CCR3 is important for migration of mast cells in neurofibroma
Wei-Chun Tai, Sin-Ting Wang, Chieh-Shan Wu, Tze-Yi Lin, Meng-Tse Wu
DERMATOLOGICA SINICA 28 (2010) 146–153

Background Neurofibroma consists of abundant extracellular matrix and many types of cells, including Schwann cells (SCs), mast cells (MCs), fibroblasts and endothelial cells. As SCs have been found to be the cell of origin for neurofibroma, how MCs may migrate into the tumor has not been fully clarified. Given that chemokine receptor CCR3 is found predominantly expressed by differentiated MCs, we postulated that CCR3 may play a role in the homing of MCs to neurofibroma. The goal of this stu ..................More
  Case Report
  Coccidioidomycosis with cutaneous manifestation of erythema nodosum in Taiwan
Chien-Ming Chen, Hua-En Lee, Shu-Ying Li
DERMATOLOGICA SINICA 28 (2010) 154–158

Coccidioidomycosis is a fungal disease endemic to the southwestern USA, northern Mexico, and focal areas in Central and South America, but it is rarely reported in Taiwan. We report a case of coccidioidomycosis of probable pulmonary origin in a young woman, who came back to Taiwan after a 10-month stay in the Central Valley of California. Coccidioidomycosis was suspected by typical constellation of symptoms and signs of Valley fever and subsequent desert rheumatism. The diagnosis was confir ..................More
  Identification of Merkel cell polyomavirus in Merkel cell carcinoma tissue: case report of a Taiwanese patient
Wen-Tsao Ho, Jonathan Te Peng Tseng, Chung-Hong Hu, Wei-Hwa Lee, Tsung-Hsien Tsai
DERMATOLOGICA SINICA 28 (2010) 159–162

Merkel cell carcinoma (MCC) is a rare malignancy with aggressive behavior mostly seen in the elderly and immunosuppressed patients. In 2008, the clonal integration of a new human polyomavirus, named Merkel cell polyomavirus (MCPyV), was found to be closely associated with the development of MCC. This correlation was established by subsequent reports, mostly in Caucasians. To evaluate whether this correlation is also relevant among the Taiwanese population, we used polymerase chain reaction ..................More
  Allergic contact dermatitis induced by zinc pyrithione in shampoo: a case report
Chih-Wei Hsieh, Mei-Eng Tu, Yu-Hung Wu
DERMATOLOGICA SINICA 28 (2010) 163–166

Shampoo-induced allergic contact dermatitis is difficult to diagnose clinically because it can involve multiple and variable areas where the shampoo flows. Zinc pyrithione is a common active agent in medicated shampoo that is known to have good anti-dandruff and antifungal effects. Despite its low risk of sensitization, cases of allergic contact dermatitis still occur because of the popularity of such products. We report a 33-year-old man who developed pruritic rash on his scalp, face, neck ..................More
  Hydroa vacciniforme-like lymphoma: a case report and literature review
Hung-Chien Lin, Sheau-Chiou Chao, Kong-Chao Chang, J. Yu-Yun Lee
DERMATOLOGICA SINICA 28 (2010) 167–172

Hydroa vacciniforme (HV) is a photosensitivity disorder in childhood characterized by recurrent vacciniform vesicles, necrotic ulcers, and scars on sun-exposed areas. HV-like lymphoma is a rare variant of cutaneous T-cell lymphoma. HV, atypical HV and HV-like lymphoma belong to the spectrum of Epstein-Barr virus (EBV)-associated lymphoproliferative disorders. We report a fatal case of HV-like lymphoma in a 31-year-old man with a 16-year history of recurrent vacciniform papulovesicular erupt ..................More
  Bullous pemphigoid associated with acquired hemophilia
Ching-Yin Chen, Ya-Hui Chen, Ji-Chen Ho, Chieh-Shan Wu
DERMATOLOGICA SINICA 28 (2010) 173–176

A 24-year-old man had bullous pemphigoid confirmed by histopathology, direct immunofluorescence, and a salt-split skin immunofluorescence examination in another hospital. He was treated with prednisolone 15 mg per day and was stable for 2 years. The patient was then admitted to our hospital for simple fasciotomy of an extensive and painful intramuscular hematoma over the right thigh with impending compartment syndrome from a machine injury over the right wrist and right thigh. Extensive ..................More
  Resident Forum
  A 25-year-old man with a dome-shaped translucent nodule on the glans penis
Yi-Shan Liu, Jyh-Seng Wang, Tzong-Shiun Li
DERMATOLOGICA SINICA 28 (2010) 177–178

A 25-year-old uncircumcised man presented with a 2-year history of an asymptomatic erythematous papule on the ventral aspect of the penile shaft. The lesion had become a larger translucent nodule 3 days previously. The patient stated that he recently had frequent and vigorous sexual activity with his steady partner. No additional genitourinary symptoms were mentioned. On physical examination, a solitary 1.2-cm dome-shaped translucent and elastic nodule was observed on the ventral shaft of th ..................More
  Multiple cutaneous abscesses in a patient with Sjögren’s syndrome
Yi-Ting Lin, Cheng-Sheng Chiu, Tseng-tong Kuo
DERMATOLOGICA SINICA 28 (2010) 179–180

A 63-year-old woman presented with multiple tender, nonulcerating, erythematous nodules on her right hand and forearm for 10 days (Figure 1A). She was suffering from Sjögren’s syndrome for more than 1 year and had been treated continually with azathioprine and prednisolone. Under the tentative diagnosis of erythema nodosum, an incisional biopsy was performed on her right forearm. Histopathology showed septolobular panniculitis, heavy infiltrates of neutrophils and granulomatous inflam ..................More
  A solitary nodule of the right cheek of a 25-year-old man
Hsin-Peng Lin, Tze-Yi Lin, Jen-Hung Yang
DERMATOLOGICA SINICA 28 (2010) 181–182

A 25-year-old man presented with a 1-year history of a small nodule on the right cheek. The nodule presented as an illdefined, reddish lesion, with a diameter of 5 mm (Figure 1). The nodule was excised and subjected to pathological examination, which revealed pleomorphic spindle and epithelioid cells infiltrating dermal collagen bundles. These cells showed discernible downward maturation (Figure 2). Microscopic examination under a high-power field showed nuclear enlargement, pleomorphism, an ..................More
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