Back issues No.1 - 2011  
  Enhancement techniques for improving 5-aminolevulinic acid delivery through the skin
Li-Wen Zhang , Yi-Ping Fang , Jia-You Fang

Photodynamic therapy (PDT) is a popular technique for skin cancer treatment. Protoporphyrin IX, which is a photosensitizing agent, converted enzymatically from the prodrug 5-aminolevulinic acid (ALA), is used as a photosensitizer in PDT for cancer. However, ALA penetrates with difficulty through intact skin; therefore, improving delivery systems for ALA in the skin will play an important role in ALA-PDT. Enhancement of ALA skin penetration can be achieved by physical methods, such as iontoph ..................More
  Original Study
  Lymphomatoid papulosis: a clinical and histopathologic review and follow-up study of 34 cases in Taiwan
Jheng-Wei Lin , Wen-Jin Shiau , Ching-I Lu , Chang-You Tsai , Wen-Ron Wong , Rosaline Chung-Yee Hui

Background: Lymphomatoid papulosis (LyP) is a rare condition within the spectrum of CD30þ cutaneous lymphoproliferative disorders that is not well documented in Taiwan. This study aimed to analyze its clinical manifestations, diagnostic histopathology, clinical course, and treatment response among Taiwanese. Methods: A retrospective chart review was performed on patients diagnosed with LyP at a Taiwanese medical center from 1992 to 2008. Results: There were 34 patients with biopsy-pr ..................More
  Skin manifestations of gefi tinib and the association with survival of advanced non-small-cell lung cancer in Taiwan
Shiou-Han Wang , Chih-Hsin Yang , Hsien-Ching Chiu , Fu-Chang Hu , Chih-Chieh Chan , Yi-Hua Liao , Hsiao-Chin Chen , Chia-Yu Chu

Background: Epidermal growth factor receptor antagonists, such as gefitinib, erlotinib, and cetuximab, have been used in treating carcinomas. The efficacies have been proposed to correlate with skin reactions, but the most important predictive indicator is still unknown. Our aim was to investigate the types of skin toxicities and to analyze the major therapeutic predictive indicators in Taiwan. Methods: A retrospective analysis was used to study 68 patients with advanced non-small-cell lung ..................More
  Case Report
  A novel nonsense mutation in the TRPS1 gene in a case of trichorhinophalangeal syndrome type I
Li-Hsuan Chen , Chung-Chu Ning , Sheau-Chiou Chao

The trichorhinophalangeal syndromes are rare malformation syndromes with autosomal dominant inheritance. Diagnostic features include distinctive facial dysmorphisms and various skeletal abnormalities. The affected gene, the TRPS1 on 8q24.1, was first identified in 2000 and more than 50 mutations have been found. We present a patient with a novel nonsense mutation in the TRPS1 gene. ..................More
  Infantile generalized pustular psoriasis: a case report and review of the literature
Yung-Shun Su , Gwo-Shing Chen , Cheng-Che E. Lan

Infantile generalized pustular psoriasis (von Zumbusch) is a rare form of psoriasis. Here, we report a 3-month-old Taiwanese girl who was treated with Chinese herbal medicine for abdominal fullness starting at 1 month of age. Around 1 month into the treatment, sudden onset of generalized erythematous plaques with scales and pustules was noted which lasted for 1 month. Histopathology of the skin lesion revealed accumulation of polymorphs within the parakeratotic stratum corneum and subcorneal ..................More
  Lipedematous alopecia with mucinosis: report of the fi rst case in Taiwan
Jui-Hung Ko , Yi-Chin Shih , Cheng Hong Toh , Hua-En Lee , Tseng-tong Kuo , Rosaline Chung-Yee Hui

Lipedematous alopecia is an uncommon disease that mainly affects African American and Egyptian women. This report is of an 18-year-old Taiwanese woman who presented with asymptomatic boggy and thickened scalp for 10 years. In the last 6 months, there was diffuse hair loss on the affected scalp without scarring. Histopathologically, there were increased thickness of subcutaneous fat layer, mild perivascular lymphocytic infiltration, and separated collagen bundles in the dermis. Alcian blue st ..................More
  Tungiasis: a case report and review of the literature
Chieh-Wen Chen , Haw-Yueh Thong , Shiou-Hwa Jee

Tungiasis is a cutaneous parasitic infection caused by the sand flea Tunga penetrans. This infection is endemic to Central and South America, the Caribbean, and sub-Saharan Africa and is more prevalent in resource-poor communities. Increased air travel, emigration from, and immigration to these countries can lead to the import of T. penetrans to travelers’ hometowns. In recent times, dermatologists have encountered many such tropical cutaneous infections, and they should promptly diagnose ..................More
  Plaque-type warty dyskeratoma of the scalp with multiple follicular involvements
Chia-Hung Wei , Ya-Ching Chang , Tseng-tong Kuo

A 47-year-old woman presented with an asymptomatic brown plaque on her scalp for many years (Figure 1). The lesionwas a welldemarcated, 3*2-cm, hyperkeratotic brown plaque with multiple yellow follicular plugs on the vertex. There was no discharge or bleeding. Oral mucosa, vulva mucosa, and nails were all normal. Laboratory examinations, including hemogram and biochemical studies, were within normal limits. Histopathological examination revealed multiple cup-shaped epidermal invagination ..................More
  Effective treatment of extensive and recalcitrant plantar warts associated with human papillomavirus-52 by oral acitretin
Ching-Yin Chen , Tien-Yi Tzung

A healthy 27-year-old Taiwanese man presented with extensive and recalcitrant plantar warts on his right foot for more than 10 years. When he was 14 years old, three discrete coin-sized thick scaly hyperkeratotic plaques with spiny rough surface were noted over his right sole. Skin biopsies had been performed twice in other medical institutes and verruca plantariswas diagnosed at that time. Various conventional therapies, including cryotherapy, electrocauterization, chemical cauterization ..................More
  Resident Forum
  Annular erythematous plaques on the right chest wall of a 55-year-old woman
Hui-Ju Yang , Cheng-Che E. Lan , Gwo-Shing Chen

A fifty-five-year-old postmenopausal woman first visited our dermatological department in February 2009 because of a history of progressive appearance of annular pruritic plaques on the right chestwall for 1 month (Figure 1). She had went to multiple local medical doctors for help; and under the impression of eczema or fungal infection, the patient was treated empirically with topical steroid and antifungal drugs, but the therapeutic response was poor. On physical examination, an annular lesi ..................More
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