Back issues No.2 - 2011  
  Original Study
  Multiple allergies to metal alloys
Mei-Eng Tu , Yu-Hung Wu

Background: Metals are well-known allergens that are most commonly encountered as alloys rather than as the pure substance. However, induction of multiple metal allergies by alloys has not been widely reported. Objective: The aim of this study was to evaluate the prevalence of multiple metal allergies in metalallergic patients. Methods: From August 1996 to September 2008, 97 patients (53 females and 44 males) in whom metal dermatitis was suspected were patch tested with the European standa ..................More
  Brief Report
  Skin diseases in Turkish soldiers
Sezai Sasmaz , Mustafa Celik

This study aimed to determine the prevalence of skin diseases among soldiers who were assigned duties in Kahramanmaras, a province of east Mediterranean region of Turkey. One hundred eighty-eight soldiers were assessed for skin diseases by a complete dermatological examination and the findings were recorded to a form. Apart from the low number of older ones, the soldiers were of 20e22 years. The diagnosis of superficial fungal infections was made by the use of potassium hydroxide preparation ..................More
  Case Report
  Blueberry muffin baby with acute myeloid leukemia and spontaneous remission
Ya-Wen Hsiao , Fang-Wen Tseng , Yi-Ling Shih , Tseng-tong Kuo , Tang-Her Jaing , Rosaline Chung-Yee Hui

Blueberry muffin baby is a rare neonatal skin disorder. Causes for the generalized hemorrhagic purpuric eruptions include congenital infections, hemolysis, and tumors.We report a 2.5-month-old female baby with a blueberry muffin appearance, respiratory distress, and decreased activity and appetite. Skin biopsy showed diffuse infiltrates of myeloperoxidase- and lysozyme-positive blast-like cells in dermis and superficial subcutis. Bone marrowstudy confirmed the diagnosis of acute monocytic le ..................More
  Omenn syndrome: a case report and review of literature
Chia-Chi Hsu , Julia Yu-Yun Lee , Sheau-Chiou Chao

Exfoliative dermatitis or erythroderma in infancy is rare. Clinicians need to be alert to the possible diagnosis of Omenn syndrome (OS), a rare form of combined immunodeficiency in infants presenting with recurrent infections, erythroderma, lymphadenopathy, hepatosplenomegaly, eosinophilia, and increased serum IgE levels. OS is fatal unless treated by hematopoietic stem cell transplantation. We described a 26-day-old boy who had presented with diffusely thick scales on the scalp and some pu ..................More
  Differentiating antiepiligrin cicatricial pemphigoid from epidermolysis bullosa acquisita by indirect immunofl uorescence of skin substrates lacking Type VII collagen or laminin 332: a case report and review of literature
Chih-Pin Chen , Richard Plunkett , Raminder Grover , Song-Jen Hong

Antiepiligrin cicatricial pemphigoid (AECP) is a chronic autoimmune subepidermal blistering disease characterized by clinical features of cicatricial pemphigoid and circulating IgG antibasement membrane autoantibodies directed against laminin 332. There is growing evidence of an increased relative risk for solid cancers and lymphomas in AECP patients, especially in the 1st year after the onset of blisters. However, it is difficult to distinguish patients with initially skin-predominant AECP ..................More
  Focal dermal hypoplasia: report of a Taiwanese case
Meng-Chi Wu , Sheau-Chiou Chao , Julia Yu-Yun Lee

Focal dermal hypoplasia (FDH), or Goltz syndrome, is a rare X-linked dominant ectodermal and mesodermal disease involving the skin, distal limbs, and eyes. About 95% of the cases appear de novo, and 90% are females. Recent studies reveal that FDH is caused by mutations in the PORCN gene. Female patients are either heterozygous or mosaic for PORCN mutations, whereas all male patients are mosaic. About 5% of the female patients analyzed have no detectable mutations or microdeletions of PORCN g ..................More
  Myocarditis in dapsone-induced drug reaction with eosinophilia and systemic symptoms — a case report and review of the literature
Wei-Hsuan Li , Han-Nan Liu , Ding-Dar Lee

Dapsone (4,40-diaminodiphenylsulfone) has been used for a variety of dermatological conditions. Dapsone-induced drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe drug reaction characterized by fever, cutaneous eruption, and systemic involvement.We present a case of dapsone-induced DRESS, which resulted in fever, maculopapular eruptions progressing to exfoliative dermatitis, cervical lymphadenopathy, transaminitis, and hypersensitivity myocarditis resulting in ..................More
  The many faces of necrobiosis lipoidica: a report of three cases with histologic variations
Pei-Shan Yen , Kuo-Hsien Wang , Wei-Yu Chen , Ya-Wen Yang , Wen-Tsao Ho

Necrobiosis lipoidica (NL) is a granulomatous disease with unknown etiology and pathogenesis. Clinically, it is characterized by yellow-brown atrophic plaques with inflammatory rims on shins. Histologically, it shows diffused palisade and interstitial granulomatous dermatitis with focal connective tissue degeneration (necrobiosis). We described three non-diabetic NL cases with unusual histologic features. All patients presented erythematous to brownish plaque(s) on the shin(s). In Case 1, in ..................More
  Herpes zoster with autonomic dysregulation presented as alteration in local microcirculation: a case report
Tommy Chih-Chieh Chang , Yi-Ying Chin , Cheng-Che Eric Lan

A 68-year-old-man without any systemic disease presented at our dermatology outpatient clinic with the chief complaint of pain described as throbbing and burning along his right abdominal wall. This is followed by an eruption of clustered vesicles along the right T10–T12 dermatome. After admission and treatment with intravenous acyclovir for 3 days, the patient was discharged with further follow up. During a routine check up, 1 month after discharge, the patient showed full recovery of ..................More
  Unilateral discoid lupus erythematosus at the site of a healed abrasion wound: an illustration of isotopic response
Wei-Chih Ko , Chih-Ming Hung , Wang-Cheng Ko , Yu-Fu Chen , Tsen-Fang Tsai

A 35-year-old man presented in February 2010 with a 3-year history of asymptomatic scaly erythema on his right face. Initially, some asymptomatic red-purple, pea-sized papules developed on his right cheek. The papules then increased in number and extended gradually, forming confluent plaques on his right face in 2 years. The skin lesion, however, has been confined to his right face since onset. The patient did not recall any local trauma history but on review of his old medical chart, he ..................More
  Resident Forum
  Multiple flesh-colored fi rm papules on the cheeks of an adult woman
Chia-Hung Wei , Hua-En Lee , Lih-Jen Yang

A 68-year-old Chinese woman, without underlying disease, presented with multiple asymptomatic flesh-colored papules on her bilateral cheeks for 20 years (Figure 1). She had had a history of severe acne when she was a teenager. A physical examination revealed many scattered 2- to 3-mm firm subcutaneous papules over her bilateral cheeks and forehead. She had received antiacne topical agents and fractional resurfacing, but there was no significant improvement. Laboratory results, including c ..................More
  Nodules on the trunk and the arm of an 8-year-old boy
Yi-An Chen , Hung-Chien Lin , Sheau-Chiou Chao

An 8-year-old boy presented with three painless nodules on the abdomen, back, and left arm for the duration of 1 year (Figure 1). The skin examination showed three 10 mm 6 mm skin-colored, well-circumscribed, dome-shaped nodules on the abdomen, lower back, and left antecubital fossa. The patient had strabismus and left ptosis for 2 years, and maculopathy was noted for 1 month. He had no hearing loss or tinnitus. Tracing back his medical history, he had relative attention deficit, poor me ..................More
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