Back issues No.3 - 2011  
  Original Study
  Potential drug interactions in dermatologic outpatient prescriptions—experience from nationwide population-based study in Taiwan
Ying-Jui Chang , Min-Li Yeh , Yu-Chuan Li , Chien-Yeh Hsu , Yung-Tai Yen , Po-Yen Wang , Thomas Waitao Chu

Background Adverse drug reactions increase morbidity and mortality, and potential drug interactions (DIs) increase the probability of adverse drug reactions. Objectives To survey the potential DIs of dermatologic outpatient prescriptions from the National Health Insurance Research Database of Taiwan. Methods All prescriptions written by dermatologists in 2000 were analyzed to identify potential DIs among drugs appearing on the same prescription sheet. Results Of 150.6 million prescr ..................More
  Methicillin-resistant Staphylococcus aureus in skin and soft tissue infections and minocyclin treatment experience in the dermatological setting of eastern Taiwan
Tzu-Chun Lin , Cheng-Huang Chang , Song-Jen Hong , Yeong-Chuan Tsai , Chung-Hsing Chang

Background Staphylococcus aureus (S aureus) is the major cause of skin and soft tissue infections (SSTIs). Increased methicillin-resistant strains have attracted a global concern. The aim of this study is to evaluate the prevalence of methicillin-resistant S aureus (MRSA) SSTIs in dermatologic settings and evaluate their susceptibility results. Methods A retrospective chart analysis of patients diagnosed with SSTIs in the Department of Dermatology, Buddhist Tzu Chi General Hospital in Huali ..................More
  Case Report
  Successful treatment of superficial basal cell carcinoma in the central face by photodynamic therapy in an Asian woman with dermoscopic diagnosis and a serial follow-up
Ya-Wen Hsiao , Fang-Wen Tseng , Chih-Hsun Yang , Cheng-Sheng Chiu

Superficial basal cell carcinoma and tinea nigra sometimes share similar clinical manifestations. Herein, we report the case of a 56-year-old Asian woman with superficial basal cell carcinoma located on her philtrum, which was initially misdiagnosed as tinea nigra. We also describe the different distinguishing features of this lesion under dermoscopic examination to improve the diagnostic accuracy. Because of the relatively low rate of metastasis and less aggressive nature of a superficial basal ..................More
  Bullous pemphigoid in a chronic renal allograft rejection patient: a case report and review of the literature
Tse-Yuan Liaw , Shang-Jyh Hwang , Daw-Yang Hwang , Gwo-Shing Chen

Bullous pemphigoid (BP) is an autoimmune blistering disorder of the skin. Various provocative factors have been proposed. However, BP in renal transplantation patients has scarcely been reported. Herein, we report the case of a 27-year-old man who received cadaveric renal transplantation 10 years ago presenting with bullous eruption during chronic renal allograft rejection phase, with the renal allograft being the possible trigger stimulus for BP development in our case. Bullous lesions were soo ..................More
  Progressive nodular histiocytosis: a rare type of xanthogranuloma
Fu-Chen Chuang , Erick Chern , Wei-Ming Wu

Progressive nodular histiocytosis is a rare non-Langerhans histiocytosis. It tends to occur in adult with progressive course that differentiates from other groups of xanthogranuloma. The clinical presentation is characteristic and disfiguring of the face is not uncommon. Extracutaneous involvement and metabolic association were reported in a few cases. Treatment is unsatisfactory and follow-up is suggested for possible complication. Herein, we reported a typical case of the disease. ..................More
  Langerhans cell hyperplasia in the tumor stage of mycosis fungoides: a mimic of Langerhans cell histiocytosis
Tzu-Chun Lin , Po-Yuan Wu , Tze-Yi Lin , Su-Peng Yeh , Shyh-chang Chen , Tsong-Liang Lee
DERMATOLOGICA SINICA 29 (2011) 101-105

Mycosis fungoides is a form of cutaneous T-cell lymphoma (CTCL). Malignant CD4+ T cells have been found to adopt the T-regulatory (Treg) cell phenotype and function. We present the case of a 66-year-old man diagnosed with mycosis fungoides that was progressing from the plaque to the tumor stage. The histopathological examinations showed that the Langerhans cell (LC) infiltration in the skin lesion of the tumor stage was greater than that in the patch/plaque stage; the tumor stage lesions resembl ..................More
  Systemic isotretinoin with topical tretinoin cream in the treatment of multiple warty dyskeratomas
Ying-Ling Kuo , Yu-Hung Wu , Ying-Jui Chang
DERMATOLOGICA SINICA 29 (2011) 106–108

A 29-year-old Taiwanese man initially presented with a painful red nodule on the right cheek for several days. A total excision was arranged. Histopathologically, the lesion demonstrated features of warty dyskeratoma (WD) characterized by a dilated cystic epidermal invagination with a hyperkeratotic and parakeratotic plug. Suprabasal acantholysis was prominent, as were acantholytic and dyskeratotic cells, corps ronds, and grains. He came to our clinic 2 years later because more lesions appeared ..................More
  A novel deletion mutation in the adenosine deaminase RNA-specific gene in a Taiwanese patient with dyschromatosis symmetrica hereditaria
Yi-An Chen , Sheau-Chiou Chao , Julia Yu-Yun Lee
DERMATOLOGICA SINICA 29 (2011) 109–110

A 10-year-old boy was referred to our dermatology department with mottled hyperpigmented and hypopigmented macules over the upper extremities and neck for about 5 years (Figure 1). There was no history of prolonged sun exposure. The skin lesions were more prominent in summer and improved in winter. He was otherwise healthy except for allergic rhinitis. No other family members had similar skin lesions. Skin biopsies were done from a hyperpigmented macule and a hypopigmented macule. The hyperpigm ..................More
  Resident Forum
  Pruritic lichenoid lesions on the vulva of an 11-year-old girl
Chia-Chi Hsu , Chao-Kai Hsu , Hung-Chien Lin , Chien Hun Huang , Julia Yu-Yun Lee
DERMATOLOGICA SINICA 29 (2011) 111–112

An 11-year-old premenarcheal Taiwanese girl presented with a 2-year history of itchy papules on the external genitalia. The itching was generally mild and intermittent but was aggravated by heat or during hot weather. These lesions increased gradually and had poor response to topical corticosteroid, antibiotic, or antifungal therapy. Examination revealed numerous, coalescing, 1-mm to 2-mm, slightly erythematous lichenoid papules on the labia majora. Many papules were surmounted by tiny white mil ..................More
  Diffuse papulosquamous eruptions in an HIV patient presenting with negative rapid plasma reagin test
Ming-Cheng Chien , Su-Ying Wen
DERMATOLOGICA SINICA 29 (2011) 113-114

A 35-year-old homosexual man presented to our dermatology clinic with a three-week history of skin rashes, on a background of current human immunodeficiency virus (HIV) infection and a negative testing result for syphilis infection. He was regularly followed-up in the infection out-patient department for the past two years. On physical examination, numerous pinkish to reddish oval maculopapules, with diameters ranging from 2 to 10mm, and overlying fine scales and crusts were seen on the neck, ch ..................More
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