Back issues No.4 - 2011  
  Original Study
  Effect of dimethoxycurcumin beyond degradation of androgen receptor
Wei-Ming Wang, Hsiao-Chun Cheng, Ying-Chun Liu, Yung-Lung Chang, Shu-Ting Liu
DERMATOLOGICA SINICA 29 (2011) 115-120

Background Androgen receptor (AR) plays an important role in the pathogenesis of prostate cancer and acne. Dimethoxycurcumin is a newly found enhancer of AR degradation, which highlights its potential for treatment of AR-related disorders. Follicular hyperkeratosis is one essential factor in the complicated pathogenesis of acne, in which some dermatopathologists have observed overexpressed psoriasin, an activator protein (AP)-1-targeted gene product. Methods We used the HaCaT cell line to d ..................More
  Serum levels of minerals and vitamins in two categories of female alopecia subjects using hair relaxer
A.A. Iyanda, J.I. Anetor, D.P. Oparinde
DERMATOLOGICA SINICA 29 (2011) 121-124

Background In an earlier study, we identified an association between hair relaxer-induced alopecia and decreased zinc levels. This study hopes to identify if age at first exposure to hair relaxer plays a role in the development of alopecia in the small percentage of women of African descent who use hair-relaxing products for hair-straightening purposes and develop lingering, nonresolving alopecia. Methods Two categories of subjects were recruited for the study. These groups—Group A and Gr ..................More
  Case Report
  Early-onset childhood sarcoidosis: a case report
Lai-San Wong, Ji-Chen Ho, Yu-Ta Yen
DERMATOLOGICA SINICA 29 (2011) 125-128

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology and it most commonly affects young adults. Childhood sarcoidosis is relatively rare; older children usually present a picture similar to that of adults, with frequent hilar lymphadenopathy and pulmonary infiltration. Early-onset (<4 years of age) childhood sarcoidosis is a unique disease and has a different presentation. It is characterized by arthritis, uveitis, and cutaneous involvement. The prognosis of early-onset child ..................More
  Palisaded neutrophilic and granulomatous dermatitis associated with the initiation of etanercept in rheumatoid arthritis: a case report
Chia-Lun Chou, Kuo-Hsien Wang, Ying-Yi Chiang
DERMATOLOGICA SINICA 29 (2011) 129-133

Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an unusual entity with variable clinical manifestations and histopathological features. It is associated with a variety of immune-mediated systemic diseases, most commonly in rheumatoid arthritis. We report a 42-year-old female with a long-standing history of rheumatoid arthritis, presenting with multiple pruritic erythematous papules and nodules on the lower legs 1 month after beginning treatment with etanercept. Microscopic examinat ..................More
  Concurrent pyoderma gangrenosum and subcorneal pustular dermatosis in a patient with monoclonal IgA/λ gammopathy
Ya-Wen Hsiao, Hua-En Lee, Tseng-Tong Kuo
DERMATOLOGICA SINICA 29 (2011) 134-136

Subcorneal pustular dermatosis (SPD) and pyoderma gangrenosum (PG) are two neutrophilic dermatoses. Coexistence of these diseases in the same patient is rare and may be a strong indicator of IgA dysglobulinemia. We describe a 69-year-old man who presented with waxing and waning flaccid pustules covering his trunk and four limbs. Poorly healing ulcerations, which usually progressed into larger nodules after debridement, were also noted. Repeated cultures were negative for bacteria, and the patien ..................More
  Dyschromatosis universalis hereditaria: a familial case with ultrastructural skin investigation
Yi-Ying Chin, Gwo-Shing Chen, Stephen Chu-Sung Hu, Cheng-Che E. Lan
DERMATOLOGICA SINICA 29 (2011) 137-141

Dyschromatosis universalis hereditaria (DUH) is a rare disease that is inherited both in autosomal dominant and autosomal recessive patterns. It is characterized by appearance of pinpoint to pea-sized hypo- and hyper-pigmented macules distributed in a reticulated pattern over the trunk and limbs within the first few years of life. Although the pathogenesis is still not clear, some authors proposed that decreased melanosome synthesis rate may underlie this disorder. We describe a 56-year-old fema ..................More
  Corticosteroid-induced Dercum’s disease
Wei-Chih Ko , Chih-Ming Hung , Tsen-Fang Tsai , Wang-Cheng Ko , Yu-Fu Chen
DERMATOLOGICA SINICA 29 (2011) 142–143

Case report A 37-year-old woman presented with progressive generalized tightening of the skin affecting the face, upper back and proximal arms for 6 years. She was initially diagnosed as scleroderma at the rheumatological department. Because of poor treatment response to cyclophosphamide and methylprednisolone, skin biopsy was performed in the dermatological department. Based on presence of irregularly oriented and separated collagen fibers with mucin deposition in the dermis, scleromyxedema w ..................More
  Large cell acanthoma manifesting as multiple white papules on extremities
Yi-Fang Wu , Jui-Hung Ko , Tseng-tong Kuo , Ya-Ching Chang , Fang-Wen Tseng , Wen-Chin Hsiao ,Yue-Zon Kuan
DERMATOLOGICA SINICA 29 (2011) 144–146

Case 1 A 39-year-old woman with essential hypertension and diabetes mellitus presented with multiple asymptomatic white papules on her bilateral upper extremities for more than 10 years. They were small well-defined, flat-topped white papules measuring 0.2–0.5cm (Figure 1A). A skin biopsy taken from her left upper arm showed basket weave hyperkeratosis and a well-demarcated area of slightly thickened epidermis composed of enlarged cells with nuclei larger than those of the adjacent normal ep ..................More
  Resident Forum
  Peculiar brownish eruption and superficial lymphadenopathy in a middle-aged man
Pei-Chun Chen, Chieh-Shan Wu, Hui-Wen Tseng, Hui-Hwa Tseng
DERMATOLOGICA SINICA 29 (2011) 147–148

Case report A 49-year-old Taiwanese male developed many discrete irregularly shaped brownish macules and patches (diameter 0.3–4.0cm) that had disseminated over his entire body, predominantly on the head and back; these macules and patches persisted for 8 months (Figures 1A and 1B). The lesions had begun on his face and had gradually spread to his trunk and extremities. A computed tomography scan revealed multiple palpable and non-tender lymph nodes in the occipital, periauricular and subman ..................More
  Mimicking each other: psoriasis with tinea incognito
Aleksandar Jankovi c´ , Ivana Bini c´ , Jasmina Gligorijevic´ , Dimitrije Jankovi c´ , Milanka Ljubenovi c´ ,Sne ž ana Jan cˇ i c
DERMATOLOGICA SINICA 29 (2011) 149–150

Case report A girl aged 17 years presented at our clinic with a 12-year history of psoriasis and a typical clinical presentation of psoriasis vulgaris. During her first visit, she had generalized erythematous papules and plaques, except on her face, with silvery white, dry scales. Lesions were oval and round in shape and were various sizes followed with intensive pruritus. Besides these lesions, she had several slightly different lesions on her legs, similar to psoriasis but with less infiltra ..................More
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