Back issues No.2 - 2012  
  Original Study
  Anhidrotic ectodermal dysplasia—A case series in a medical center in southern Taiwan
Kuei-Chung Liu , Ching-Yuang Huang , Sheau-Chiou Chao

Background Anhidrotic ectodermal dysplasia (EDA) is a rare genodermatosis that causes developmental defects in ectoderm-derived structures. The clinical triad consists of hypodontia, hypotrichosis, and anhidrosis with other additional symptoms. The aim of this study is to summarize the clinical manifestations, family history, histopathological findings of the skin, and gene mutations in EDA patients who presented at a medical center in order to make the disease better known among medical person ..................More
  Clinical characteristics of late-onset vitiligo in an Iranian population
Iraj Esfandiarpour , Saeedeh Farajzadeh

Background The age of onset of vitiligo is before 20 years in approximately in 50% of patients, and its incidence decreases with increasing age. In this study, our aim was to analyze the epidemiological and clinical factors of patients with late-onset vitiligo and compare these to patients with early-onset vitiligo. Methods Eight hundred and twenty-five consecutive patients with vitiligo were examined from March 2003 through May 2006. The patients were divided into late-onset (disease onset ..................More
  Case Report
  Porocarcinoma in situ showing follicular differentiation: A case report
Chia-Lan Ou , Chien-Jui Cheng , Kuo-Hsien Wang

Poroid neoplasm is a skin appendage tumor that has both benign and malignant counterparts. It has traditionally been regarded as of eccrine origin and has four types: intraepidermal poroma (hidroacanthoma simplex), poroma, dermal duct tumor, and poroid hidradenoma. Here we describe the case of a 64-year-old woman who had a verrucous, erythematous to brownish tumor on her left buttock for many years. Histopathology revealed an intra-epidermal poroid tumor with both benign and malignant parts. The ..................More
  Concomitant occurrence of acneiform eruption, alopecia areata, and urticaria during adalimumab treatment in a patient with pustulosis palmoplantaris: Case report and literature review
Guan-Yi He , Tsen-Fang Tsai

Adalimumab is a fully human immunoglobulin G1 monoclonal antibody against tumor necrosis factor (TNF)-α that is increasingly used for the treatment of many autoimmune diseases. However, it has also been reported that adalimumab can induce many adverse cutaneous reactions, including paradoxical psoriasiform eruptions. We describe a patient with pustulosis palmoplantaris who developed four cutaneous adverse reactions, including eczematous lesions, acneiform eruption, alopecia areata, and urticari ..................More
  Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literature
Pai-Shan Cheng , Shih-Sung Chuang , Tseng-Tong Kuo , Feng-Jie Lai

Pigmented epithelioid melanocytoma (PEM), or animal-type melanoma, is an unusual variant of melanoma which has been reported to have indolent behavior and a relatively good prognosis. We report a 12-year-old girl with PEM on the third finger web of her right hand. Histopathologically, it was composed of heavily pigmented dermal epithelioid and spindled melanocytic tumor cells. A sentinel lymph node biopsy was negative, and no recurrence was noted 1 year later. We reviewed 173 previously publishe ..................More
  Congenital erythropoietic porphyria
Wen-Hao Lee , Wei-Chun Tai , Po-Yuan Wu
ATOLOGICA SINICA 30 (2012) 62-65

Congenital erythropoietic porphyria (CEP), or “Günther disease”, is a rare variant of porphyria. It is an autosomal recessive disease caused by deficient uroporphyrinogen III synthase (URO-III-synthase), the fourth enzyme in the heme biosynthetic pathway. We herein report a case of a man with the typical clinical presentations of hyper- and hypo-pigmentation and blister formation over sun-exposed areas, mutilation of the fingers, dark-purple urine, and erythrodontia with pinkish fluorescenc ..................More
  Transient zinc deficiency syndrome in a breast-fed infant due to decreased zinc in breast milk (type II hypozincemia of infancy): A case report and review of the literature
Wei-Li Yang , Chao-Kai Hsu , Sheau-Chiou Chao , Ching-Yuang Huang , Julia Yu-Yun Lee

Type II hypozincemia of infancy is a rare, hereditary zinc deficiency occurring in infants while exclusively on breast feeding. It is caused by defective transfer of zinc into breast milk. Only a few dozen cases have been reported. A 6-month-old, full-term, breast-fed female infant presented with a 3-week history of erythematous to dusky red papules and annular plaques over the perioral and diaper area as well as the digits. The eruption was accompanied by poor appetite and irritable crying. Ser ..................More
  Histiocytoid Sweet syndrome: Report of two cases and review of the literature
Ching-Fu Huang , Bai-Yao Wu , Fang-Yih Liaw , Wei-Ming Wang , Chien-Ping Chiang

Histiocytoid Sweet syndrome (SS) is a rare inflammatory disease that has recently been described as a variant of classic SS. Histopathologically, histiocytoid SS is characterized by papillary dermal edema with infiltration of histiocyte-like cells into the upper dermis. These microscopic features may be similar to those of leukemia cutis, which involves infiltration of malignant blasts into the dermis. However, the treatment and clinical prognosis of these two conditions are quite different. Her ..................More
  Dendritic cell neurofibroma with pseudorosettes: One case report and literature review
Hsin-Yin Huang , Yu-Hung Wu , Ya-Ju Hsieh

Dendritic cell neurofibroma with pseudorosettes is a recently proposed, rare variant of neurofibroma. It has a distinctive histopathological finding that is composed of two types of cells that form a pseudorosette, which may be easily misdiagnosed as other neural tumor. Here, we report one typical case in order to raise awareness of this entity. Keywords: dendritic cell neurofibroma, neurofibroma, peripheral nerve sheath tumor, pseudorosettes ..................More
  Dermoscopic features of discoid lupus erythematosus
Tsung-Ming Tsai , Kuo-Chia Yang , Tsung-Hua Tsai

An otherwise healthy 38-year-old man presented with skin lesions over his scalp and face of several months’ duration. The lesions were exacerbated after sun exposure. Physical examination showed many erythematous to brownish alopecia patches located on his scalp (Figure 1A) and atrophic plaques on his face (Figure 1B). Laboratory studies including hematologic tests, erythrocyte sedimentation rate, anti-nuclear antibody, and routine urine tests were within normal limits. Anti-dsDNA was 10 KIU/L ..................More
  Resident Forum
  Multiple brownish warty papulonodules on left dorsal hand
Che-Yi Chou, Shih-Wei Yeh

A 56-year-old nonobese man presented with progressive thickening and darkening of the left dorsal hand for 3 months. The patient denied any history of systemic disease, such as diabetes mellitus or other endocrinopathies, and there was no family history of malignancy. He reported no systemic symptoms such as weight loss, general malaise or melena, with the exception of a 1-month history of low back pain. Physical examination revealed multiple brownish warty papules and nodules over the left dors ..................More
  Multiple hypertrophic purpuric to erythematous papuloplaques on four limbs of a 38-year-old man
Yung-Yi Lee, Jui-Hung Ko, Mei-Ching Lee, Jheng-Wei Lin

A 38-year-old healthy man presented with a 6-month history of mildly pruritic skin lesions on joints of four limbs. Initially, the itchy erythematous papules developed from extensor aspects of the joints, then the papules gradually progressed to violaceous plaques. He denied any trauma history or chronic scratching on the cutaneous lesions. On physical examination, there were multiple purpuric to erythematous hypertrophic, oval-shaped, and well-demarcated plaques with varying size on the extenso ..................More
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