Back issues No.4 - 2012  
  Editorial View
  Skin as an immune organ
Guest Editor:Chia-Yu Chu
DERMATOLOGICA SINICA 30 (2012) 119–120

Over the past 20 years, the discovery that keratinocytes are immunologically active cells has reinforced the concept that the skin is an active immune organ.1 It is clear that the epidermis can function as an immunologic tissue. This is critically important to its function as a barrier to external toxins and microbes. Moreover, recent findings on the roles of antimicrobial peptides, Toll-like receptors, antigen-presenting cells, regulatory T (Treg), and interleukin-17 (IL-17)-producing T helper ..................More
  Galectins and cutaneous immunity
Huan-Yuan Chen , Chia-Hui Lo , Chi-Shan Li , Daniel K. Hsu , Fu-Tong Liu
DERMATOLOGICA SINICA 30 (2012) 121-127

Galectins are highly expressed in epithelial cells and immune cells. In skin, they can be detected in keratinocytes, melanocytes, dendritic cells, macrophages, and T cells. Galectins are present outside and inside the cells and thus may exhibit different functions through extracellular and intracellular actions. Galectins can be involved in the pathogenesis of inflammatory skin diseases by affecting growth, apoptosis, maturation, activation, and motility of keratinocytes and immune cells. Expres ..................More
  Pathophysiology of chemokines and chemokine receptors in dermatological science: A focus on psoriasis and cutaneous T-cell lymphoma
Chih-Hung Lee , Sam Tzen-Yue Hwang
DERMATOLOGICA SINICA 30 (2012) 128-135

Skin is an immunological organ with a delicate immunological network that governs the homeostasis and homing of the pro- and anti-inflammatory immune cells. Dysregulated immune response may result in psoriasis, a common inflammatory skin disease. Inappropriate immune surveillance, on the other hand, may cause the development of cutaneous lymphomas. Such homing of the immune cells likely depends on the interactions of chemokine and its receptors. Chemokine receptors and their corresponding chemok ..................More
  T helper type 17 in psoriasis: From basic immunology to clinical practice
Hsien-Yi Chiu , Yu-Pin Cheng , Tsen-Fang Tsai
DERMATOLOGICA SINICA 30 (2012) 136-141

Psoriasis is a chronic inflammatory disease mediated by a complex interplay between immune system and keratinocytes. Initially considered as a keratinocyte proliferation/differentiation disorder, an immune dysregulation was confirmed after the successful treatment of psoriasis with cyclosporine. The ying–yang theory, or T helper type 1 (Th1)/Th2 concept, was then introduced to explain the rarity of atopic dermatitis in patients with psoriasis and the aggravation of psoriasis after interferon- ..................More
  Pathomechanism of atopic dermatitis in the perspective of T cell subsets and skin barrier functions – “Which comes first, the chicken or the egg?”
Kenji Kabashima
DERMATOLOGICA SINICA 30 (2012) 142-146

Atopic dermatitis (AD) is a common skin condition that is characterized by a complex, heterogeneous pathogenesis. The possible candidates for its pathogenesis include skin barrier abnormality and allergy/immunology aspects. It has long been asked, “Which comes first, the barrier dysfunction or the allergy/immunology abnormality?” Recently, direct evidence of a link between the incidence of AD and loss-of-function mutations in the gene encoding Filaggrin has been discovered. This finding sugg ..................More
  The pharmacological mechanisms of omalizumab in patients with very high IgE levels—Clues from studies on atopic dermatitis
Tse Wen Chang , Jiun-Bo Chen , Chia-Yu Chu
DERMATOLOGICA SINICA 30 (2012) 147-153

Seventeen case series investigating the effects of omalizumab on patients with atopic dermatitis included patients whose pretreatment serum IgE was above 700 IU/ml, the upper inclusion limit specified in the product label. In all, 107 patients received omalizumab at doses of ≤375 mg every 2 weeks, which is recommended for patients with IgE <700 IU/ml. Among them, 87 improved in clinical symptoms and some did so after the first dose. Among these 87 patients, 35 and 12 had pretreatment serum IgE ..................More
  Epicutaneous sensitization with protein antigen
I-Lin Liu , Li-Fang Wang
DERMATOLOGICA SINICA 30 (2012) 154-159

In the past few decades there has been a progressive understanding that epicutaneous sensitization with protein antigen is an important sensitization route in patients with atopic dermatitis. A murine protein-patch model has been established, and an abundance of data has been obtained from experiments using this model. This review discusses the characteristics of epicutaneous sensitization with protein antigen, the induced immune responses, the underlying mechanisms, and the therapeutic potentia ..................More
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