Back issues No.2 - 2013  
  Original Study
  Efficacy and safety of etanercept in the treatment of recalcitrant psoriasis: An open-label, retrospective, observational study in Taiwan
Yi-Fang Wu, Yi-Chin Shin, Chih-Hsun Yang, Yu-Huei Huang

Background Psoriasis is a chronic inflammatory disease affecting the quality of life of patients. Traditional treatments are limited by adverse side effects. Etanercept is a biological agent used as an alternative treatment for psoriasis. Methods This open-label, observational study conducted in Taiwan involved 22 patients with recalcitrant psoriasis who received a 24-week treatment with etanercept—50 mg twice weekly (BIW) during the first 12 weeks and 25 mg BIW in the next 12 weeks. Psor ..................More
  Histopathologic and immunohistochemical distinction of condyloma and seborrheic keratosis in the genitofemoral area
Yu-Hung Wu, Pa-Fan Hsiao, Chi-Kuan Chen

Background Making a clinical and histological distinction between condyloma and seborrheic keratosis in the genitofemoral area can be difficult. This study aimed to find reliable histological and immunohistological criteria to diagnose these entities. Methods We retrospectively studied genitofemoral skin biopsy specimens obtained between January 2004 and December 2007 that had been diagnosed as showing condyloma or seborrheic keratosis. The histological findings were assessed and immunohist ..................More
  Efficacy and safety of a single treatment using a 10,600-nm carbon dioxide fractional laser for mild-to-moderate atrophic acne scars in Asian skin
Pa-Fan Hsiao, Yang-Chih Lin, Cheng-Chieh Huang, Yu-Hung Wu

Background Ablative laser therapy with carbon dioxide is effective for acne scars; however, the long downtime limits its use, especially in types III and IV skin. The fractional ablative 10,600-nm carbon dioxide laser system reportedly maximizes efficacy and minimizes side effects. The goal of this study was to evaluate the efficacy and safety of an ablative 10,600-nm carbon dioxide fractional laser system in a single treatment session on atrophic acne scars in Asian patients. Methods Twent ..................More
  Recurrent herpes labialis among health school students in Kahramanmaraş, Turkey: A cross-sectional survey
Mustafa Celik, Mustafa Haki Sucakli, Ekrem Kirecci, Hasan Ucmak, Hasan Cetin Ekerbicer, Perihan Ozturk

Objective The aim of this study was to determine the epidemiologic characteristics of, and the treatments used for, recurrent herpes labialis (RHL) in health students. Methods A cross-sectional study was conducted with the participation of 333 nursing and midwifery students. Data on the sociodemographic characteristics of the participants, their history of RHL, and the treatments were collected by means of a standard self-reported questionnaire form. Results The point prevalence of RHL ..................More
  Brief Report
  Secondary intention healing with satisfactory outcome after nodular basal cell carcinoma excision on the face
Jia-Ming Yeh, Chun-Yen Ou, Julia Yu-Yun Lee, Tak-Wah Wong

Secondary intention healing on concave areas of the face may provide acceptable cosmetic outcome after tumor excision but is underused. We evaluated cosmetic outcome and tumor recurrence of this technique in 10 patients with nodular basal cell carcinoma and one patient with basosquamous carcinoma on the face. The average size of these tumors was 1 cm. Subjective evaluations included patients' satisfaction on the degree of wound pain, ease of wound care, and satisfaction with cosmetic outcome. Ob ..................More
  Case Report
  Early stage mycosis fungoides with focal CD30-positive large cell transformation
Po-Ju Lai, Yu-Ping Hsiao, Jeng-Dong Hsu, Shiow-Jiuan Wey

Mycosis fungoides (MF) is typically an indolent disease except when large cell transformation (LCT) occurs. The incidence of LCT has been reported to range from 6% to 23% under the criterion of the presence of more than 25% of large cells in a biopsy of typical MF lesions. LCT is more common in advanced-stage MF, but very rarely found in its early stage. Herein, we present a 45-year-old woman with patch stage MF (Stage IB) who developed a papule within one patch, which revealed large cell transf ..................More
  Use of etanercept to treat toxic epidermal necrolysis in a human immunodeficiency virus-positive patient
Yung-Yi Lee, Jui-Hung Ko, Chia-Hung Wei, Wen-Hung Chung

Toxic epidermal necrolysis (TEN) is an uncommon and severe cutaneous adverse drug reaction that causes disseminated necrosis of epidermal cells and mucocutaneous detachment. Here, we report the case of a 32-year-old man with human immunodeficiency virus infection who presented with generalized violaceous macules and blister formation 4 days after the administration of mefenamic acid and amoxicillin for a dental procedure. Additional symptoms included oral ulcers and conjunctivitis. Results of sk ..................More
  Cutaneous Mycobacterium intracellulare infection presenting as multiple asymptomatic papulonodules in an immunocompetent adult: A case report and review of the literature
Yen-Yun Tsai, Po-Ren Hsueh, Cheng-Hsiang Hsiao, Tsen-Fang Tsai

Disseminated cutaneous nontuberculous mycobacteria infection is rare in immunocompetent hosts. We report a case of Mycobacterium intracellulare infection in an immunocompetent patient presenting with simultaneously developing multiple asymptomatic cutaneous papulonodules. The possibility of lung lesions as the primary focus is suspected. We review the literature for other cases of multiple cutaneous M avium complex infections in immunocompetent hosts. There are differences in the virulence of M ..................More
  Dermatopathic lymphadenitis in a patient with pemphigus vulgaris
Jen-Jung Cheng, Han Chang, Hung-Chun Shih, Shiow-Jiuan Wey, Yu-Ping Hsiao

Dermatopathic lymphadenitis (DL) is a reactive lymphoid hyperplasia that commonly involves the regional lymph nodes in patients with chronic dermatoses, such as exfoliative dermatitis, toxic-shock syndrome, pemphigus, psoriasis, eczema, and, in severe cases, mycosis fungoides. Diagnosis of DL depends on the histopathologic characteristics of paracortical T-zone expansion with melanin, hemosiderin, or lipid-laden macrophages. Lymphadenopathies in patients with chronic dermatoses may be due not on ..................More
  Primary cutaneous cryptococcosis in an immunocompetent man: A case report
Ying-Yi Lu, Chieh-Shan Wu, Chien-Hui Hong

Cutaneous cryptococcosis usually develops secondary to hematogenous spread in immunocompromised hosts. Primary cutaneous cryptococcosis (PCC) is a rare condition characterized by localized skin eruptions and positive culture for Cryptococcus neoformans but without dissemination to the internal organs. Herein, we describe a typical case of PCC in an immunocompetent male who presented with a 1-month history of scattered erythematous indurated papules and plaques on his arm and without fever. The h ..................More
  Buschke–Löwenstein tumor (giant condyloma acuminatum) successfully treated by topical photodynamic therapy: a case report
Gong-Yau Chu, Tommy Chih-Chieh Chang, Chung-Hsing Chang

Giant condyloma acuminatum (Buschke–Löwenstein tumor) is a rare sexually transmitted disease caused by human papilloma virus infection in the anogenital area. It is characterized by rapid growth, large size, local destruction, lack of spontaneous resolution, poor response to conservative therapy (e.g., cryotherapy), and a high recurrence rate. Treatment of such tumors remains challenging. We report the case of a 56-year-old Taiwanese man with a 9-month history of the Buschke–Löwenstein tum ..................More
  Blastoid mantle cell lymphoma involving skin and orbit with hypercalcemia: A case report and literature review
Juan Li, Han Ma, Xiuzhen Tong, Chang Su, Dong Zheng, Mei Chen, Chun Lu

Mantel cell lymphoma is one of the small B-cell non-Hodgkin's lymphomas and usually involves lymph nodes, bone marrow, spleen, liver, gastrointestinal tract, and Waldeyer's ring, but rarely skin and orbit. A 53-year-old man presented skin nodules and plaques on the head, trunk, and lower extremities for half a month, and the left periorbital region swelled 4 days ago. Serum calcium and lactate dehydrogenase were increased to 3.12mmol/L (normal 2.03–2.65mmol/L) and 853U/L (normal 71–231U/L), ..................More
  Neutrophilic sebaceous adenitis responsive to oral isotretinoin
Wei-Ting Chou, Tsen-Fang Tsai, Wang-Cheng Ko, Chih-Ming Hung, Yu-Fu Chen
DERMATOLOGICA SINICA 31 (2013) 102–103

Neutrophilic sebaceous adenitis (NSA) was initially described in dogs, with an unclear etiology. Only three human cases have been reported.1, 2, 3 We reported another case in an Asian man, who responded well to oral isotretinoin. The 38-year-old man had suffered from erythematous plaques with satellite papules on bilateral cheeks for 3 months. The lesions started as discrete reddish papules, which gradually enlarged into confluent annular plaques with elevated borders (Figure 1A and B). The r ..................More
  Primary cutaneous diffuse large B-cell lymphoma, leg type mimicking cellulitis
Shien-Tung Pan, Chih-Hsin Wei, Han-Yueh Kuo, Ruey-Yun Huang, Shih-Sung Chuang
DERMATOLOGICA SINICA 31 (2013) 104–106

The skin is the second most common site of primary extranodal non-Hodgkin lymphoma following the gastrointestinal tract. The 2005 World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) scheme recognizes 3 types of primary cutaneous B-cell lymphomas: primary cutaneous marginal zone B-cell lymphoma, primary cutaneous follicular center cell lymphoma, and primary cutaneous diffuse large B-cell lymphoma (DLBCL), leg type (PCLBCL-leg), with the last one carryi ..................More
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