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Transcriptional effects of inhibiting epidermal growth factor receptor in keratinocytes
Alix Gazel , Miroslav Blumenberg
DERMATOLOGICA SINICA 31 (2013) 107-119
Background
Epidermal growth factor receptor (EGFR) activation is important in human epithelial malignancies, including cutaneous squamous cell carcinoma, lung, colon, pancreatic, and other cancers. Therapies targeting EGFR are currently used to treat such cancers, but one significant drawback to EGFR inhibitor therapies is the associated skin toxicity. This toxicity usually presents as papular or pustular folliculitis, dry skin with pruritus and hair and nail abnormalities. The side effects oft ..................More |
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Changes in distribution and ultrastructure of Langerhans cells in condyloma acuminatum tissues, and analysis of the underlying mechanism
Yong-Zheng Pan , Hui-Ling Wang , Fei Wang , Dan Luo
DERMATOLOGICA SINICA 31 (2013) 120-125
Objective
To determine the changes in distribution and function of Langerhans cells (LCs) in condyloma acuminatum (CA) tissues, as well as the possible underlying mechanism.
Methods
The expression of CD1a and E-cadherin in 26 CA lesions and 10 normal prepuce tissues was determined using the streptavidin peroxidase method. The mRNA expression of CD1a and E-cadherin was determined using reverse transcriptase polymerase chain reaction. The ultrastructure of LCs was observed under a transmissio ..................More |
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Use of a purse-string suture method and blunt-ended dissector in arthroscopic surgery for axillary osmidrosis
Lai-San Wong, Erick Chern, Yuta Yen, Wei-Ming Wu
DERMATOLOGICA SINICA 31 (2013) 126-129
Background/Objectives
In recent years, the use of a suction-assisted arthroscopic shaver has become a popular method for the treatment of axillary osmidrosis. The dissection method is essential for creating adequate space for the curettage and suction process of the shaver. However, the traditional dissection process using scissors extends the wound and affects the final cosmetic result. Therefore, we developed a method to minimize the surgical wound to decrease the side-effects related to woun ..................More |
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Stress coping mechanisms in smoking psoriatics
Ilknur Altunay, Nurhan Doner, Sibel Mercan, Gulsen Tukenmez Demirci
DERMATOLOGICA SINICA 31 (2013) 130-133
Background
The link between emotional stress and smoking has previously been investigated and results have suggested that smoking is used as a way of dealing with stress. There are many studies indicating the relationship between smoking and psoriasis or emotional stress and psoriasis. However, to our knowledge, the link between smoking associated with emotional stress and psoriasis has not been shown before. Our aim was to investigate psoriatic patients' abilities to cope with stress, the rela ..................More |
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Kounis syndrome associated with benzathine penicillin G use: A case report
Arif Duran, Tarık Ocak, Serkan Öztürk, Nadir Goksugur
DERMATOLOGICA SINICA 31 (2013) 134-136
Kounis syndrome is a life-threatening medical condition that causes severe allergic reaction and acute coronary syndrome. Benzathine penicillin G is one of the most widely used antibiotics in clinical practice, but it can enhance both allergic and hypersensitivity complications. In this report, we describe the case of a 42-year-old man admitted to our hospital who presented with cryptic tonsillitis accompanied by angioneurotic edema, chest pain, and electrocardiographic variations. The patient w ..................More |
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Palmar purpuric lichen nitidus—clinicopathological and dermoscopic findings
Chun-Yu Cheng, Cheng-Sheng Chiu, Yu-Huei Huang
DERMATOLOGICA SINICA 31 (2013) 137-139
Lichen nitidus (LN) is an uncommon dermatosis of unknown etiology. LN confined to the palms is an unusual presentation and only a few cases have been reported. The clinical features may mimic pompholyx, pitted keratosis, and porokeratotic eccrine ostial and dermal duct nevus. We herein report a rare case of palmar purpuric LN with characteristic dermoscopic findings.
Keywords: dermoscopy, lichen nitidus, palm ..................More |
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Atypical fibroxanthoma-like amelanotic malignant melanoma: A case report and literature review
Chao-Kai Hsu, Sheau-Chiou Chao, Shyh-Jou Shieh, Julia Yu-Yun Lee
DERMATOLOGICA SINICA 31 (2013) 140-144
Atypical fibroxanthoma (AFX)-like malignant melanoma is very rare. Here, we report a case of amelanotic AFX-like melanoma in a 72-year-old Taiwanese woman presenting with two separate, asymptomatic, enlarging erythematous nodules within a large hypopigmented patch on her left cheek. Histologically, both lesions showed cellular nodules in the reticular dermis separated from the overlying flattened epidermis by a zone of solar elastosis or fibrosis. The tumor consisted of sheets of atypical epithe ..................More |
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Verrucous porokeratosis (porokeratosis ptychotropica) with dermal amyloid deposits
Yen-Fen Yu, Yu-Hung Wu
DERMATOLOGICA SINICA 31 (2013) 145-148
We report the case of a 43-year-old man with numerous pruritic verrucous papules and plaques on buttocks, natal cleft, penis, and scrotum for decades. He had already been diagnosed as having psoriasis or condyloma in different clinics, and received various topical medications and liquid nitrogen cryotherapy without improvement. On histopathology, there were several parakeratotic columns of cornoid lamella in the compact hyperkeratotic stratum corneum. The papillary dermis had amyloid deposition, ..................More |
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Actinomycetoma caused by Nocardia otitidiscaviarum: Report of a case in Taiwan with long-term follow-up
Min-Hui Chi , Rosaline Chung-Yee Hui , Chin-Fang Lu , Li-Cheng Yang , Shu-Ying Li
DERMATOLOGICA SINICA 31 (2013) 149-153
Actinomycetoma is a chronic granulomatous infection, with Nocardia species being one of the infecting pathogens. Infections caused by N. otitidiscaviarum are relatively rare compared with those caused by other Nocardia species. Conventional methods for the diagnosis of nocardiosis based on phenotypic characterization of the strains (e.g., morphology, histopathology) are relatively time consuming and nonspecific. Molecular techniques have become the better choice for prompt and accurate identific ..................More |
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Tegafur/gimeracil/oteracil (TS-1) induced Stevens–Johnson syndrome: Case report
Satoko Minakawa , Yasushi Matsuzaki , Koji Nakajima , Hajime Nakano , Daisuke Sawamura
DERMATOLOGICA SINICA 31 (2013) 154-156
TS-1 is an oral fluoropyrimidine anticancer drug that contains tegafur, gimeracil, and oteracil. A 78-year-old Japanese male who was diagnosed with carcinoma of the oral floor (rT4aN0M0) was prescribed a standard dose of TS-1 (80 mg/day). On Day 8 after administration of TS-1, an eruption developed. There was erythema, along with vesicles and erosions involving the lip, face, neck, trunk, limbs, and genitals. The drug-induced lymphocyte stimulation test (DLST) for TS-1 was negative on the 23rd d ..................More |
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Pagetoid reticulosis with a keloid-like appearance
Tsung-Ting Hsieh , Jen-Yu Wang , Yu-Hung Wu
DERMATOLOGICA SINICA 31 (2013) 157–158
A 31-year-old Vietnamese woman presented with a 10-year history of asymptomatic plaques on her left ankle that had slowly increased in size. She denied prior trauma to this area. The lesion did not respond to topical corticosteroid treatment. Her general health was good without other diseases and she was not taking any medication. On examination, two erythematous, well-demarcated plaques with an irregular edge were seen on her left ankle (Figure 1A and B). The clinical appearance was similar to ..................More |
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Autologous fibroblast therapy of the scar: A preclinical report
Shih-Wei Yeh , Mei-Yue Huang
DERMATOLOGICA SINICA 31 (2013) 159–160
Surgical revision, dermabrasion, and laser therapy have been developed to improve scar over the past years. However, they were often associated with undesirable side effects such as erythema and hyperpigmentation. These side effects can be circumvented by autologous fibroblast injection, which provides a better control of the number of cells delivered and the depth of their placement. In this report, we describe a 31-year-old man presented with a traumatic forehead scar treated by autologous fib ..................More |
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A case of facial hyperkeratosis induced by a cosmeceutical containing alpha-hydroxy acid and sunlight overexposure successfully treated using oral acitretin
Tsai-Ching Chou, Chung-Hsing Chang
DERMATOLOGICA SINICA 31 (2013) 161–162
Chemical peels cause destruction of the epidermis and subsequent repair. Postpeel care is important.
An 18-year-old man presented with progressive erythematous keratotic papules with associated greasy debris bilaterally on the cheeks, postauricular, and submandibular areas, and to a lesser extent the bridge of the nose and forehead, that had been present for the past 4 months (Figure 1). He was otherwise in good health and denied any similar symptoms or hereditary keratotic dermatosis among h ..................More |
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Herpes vegetans
Yen-Fen Yu, Yu-Hung Wu
DERMATOLOGICA SINICA 31 (2013) 163–164
lymphocytic lymphoma and was currently taking 2 mg chlorambucil every other day for disease control. Both tumors were eroded. One of the tumors adjacent to the scrotum was covered with a thin crust, and the other tumor on his right groin wept with serous fluid (Figure 1A–C). Owing to the suspicion of squamous cell carcinoma, an excisional biopsy of the groin lesion was performed. The pathology revealed ulceration and granulation tissue with densely and diffusely mixed cell infiltration. Multin ..................More |
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Neutrophilic dermatosis of the hands
Ching-Fu Huang, Wei-Ming Wang
DERMATOLOGICA SINICA 31 (2013) 165–167
A 78-year-old Taiwanese woman presented with fever and painful skin lesions over both palms for 2 weeks. Her medical history was unremarkable. On physical examination, infiltrating and juicy vesicular eruptions on violaceous bases were noted over the palms as well as on the ventral and lateral aspects of the fingers (Figure 1). Very few lesions extended to the dorsal aspect of the fingers. In addition, no mucosal lesions were found. Laboratory studies on admission revealed leukocytosis and neutr ..................More |
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