Back issues No.1 - 1983 / Case Report  

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Malignant Histiocytosis
Yi-Huei Wang, Chee-Ching Sun, Hsu-Po Yeh, Ming-Yang Lai, Min-Ching Shen, Kuo-Lin In
Dermatol Sinica 1: 45-50, 1983

This 52-year-old female initially noticed fever and painful subcutaneous nodules on her right flank area two months before the first admission. Under the impression of Weber-Christian disease during her hospital stay, aspirin was given, the condition improved and she was discharged. However, the skin lesions and fever recurred and she was admitted again two months later. In addition to hepatomegaly, anemia, leukopenia, abnormal liver function and hypofibrinogenemia, histopathological findings of dermal perivascular and periappendageal histiocytic iniltration with erythrophagocytosis, hepatic sinusoidal histiocytic infiltration with erythrophagocytosis and phagocytosis of erythoid element of bone marrow study were the evidences to diagnose this patient to be a case of malignant histiocytosis.
Although skin manifestation as the presenting symptom of malignant histiocytosis is rare, confronting with a patient with fever and painful subcutaneous nodules, not only the skin pathologic examination is warranted, the pathologic evaluation of the other organs should also be carried out in order not to overlook some diseases including malignant histiocytosis.

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