Back issues No.4 - 1989 / Case Report  

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Herpes Gestationis
Jon-Ton Shei, Jen-Hong Yang, Han-Nan Liu
Dermatol Sinica 7: 255-261, 1989

Herpes gestationis, a rare autoimmune cutaneous disase, occurs during pregnancy and after delivery. We report such a case of 30 year-old with the 4th pregnancy. At the 7 th month of her pregnancy, she developed intensely pruritic erythematous patches, vesicles and bullae around the umbilicus and then gradually spread to the abdomen, trunk and four limbs. Under light microscopy, subepidermal vesicle formation with marked eosinophil infiltration was identified. Direct immunofluorescence study demonstrated linear deposition of C3 along the dermo-epidermal junction. Elctron microscopic study disclosed the separation site at the lamina lucida of basement membrane zone. The HG factor was poitive, After treatment with topical steroids and oral antihistamines, her skin lesion became subsiding. She delivered spontaneously at 38 weeks of gestation with a healthy male baby weighed 2550gm. Immediate postpartum administration of prednisolone was initiated with subsequent complete disappearance of skin lesion. There was no flare up of skin lesion by the time of prsentation.

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