Back issues No.1 - 1990 / Case Report  

Full Text PDF


Secondary Syphilis with Jarisch-Herxheimer Reaction
Chang-Long Tai, Hsin-Su Yu, Tsu-Chieh Shen, Gwo-Shing Chen
Dermatol Sinica 8: 15-22, 1990

A 34-year-old male patient has had two erythematous flattn plapues on face and many reddish maculopapules on upper trunk which developed about 4 months after extramarital sexual exposure.Clinical course, biopsy findings and strong positive VDRL & TPHA disclosed a picture of "secondary syphilis".After the initial IM injection of 2.4 million units of benzathine penicillin G, generalized rose-red macules developed 3 hours later. Concurrent mild fever, headache & myalgia were also noted. The symptoms subsided within 24 hours. The above clinical & pathological changes are compatible with "Jarisch-Herxheimer reaction (JHR)" originally described by Jarisch in 1895 and Herxheimer & Kraus in 1902.The pathophysiologic changes and pathogenesis of this reaction are reviewed. In addition, differential diagnosis betwen JHR penicillin allergy reaction is discussed.

You are visitors    
Copyright © 2008 THE Taiwanese Dermatological Association. All Rights Reserved. Email: Tel:886-2-2518-5126~7 Fax:886-2-2518-5128