Back issues No.4 - 1990 / Case Report  

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Benign Cephalic Histiocytosis
Chung-Wen Ko, Whei-Mi Lien, Kou-Chang Chou, Kai-Yam Ng, Tseng-Tong Kuo, Chun-Hsiang Chang
Dermatol Sinica 8: 191-201, 1990

An 8-month-old male infant had an asymptomatic cutaneous eruptin of red-yellowish, plane papules on the face of 6-months' duration. Histopathologic examination revealed well-circumscribed histiocytic infiltrates in the papillary dermis. With special stains, lots of reticulum fibers were noted in the dermis, but lipid, mucopolysaccharides, glycogen, or iron deposits were not observed in the infiltrating histiocytes. Immunohistochemically, these histiocytes were negative for S-100 protein. By electron microscopy, many coated vesicles were seen in all histiocytes, and nearly 10% of these histiocytes contanined clusters of worm-like bodies. Multivesicular bodies and dense bodies could be found occasionally, but Birbeck's granules, laminated bodies, uique phagosomes, and fatty droplets were absent. In addition, there were some desmosome-like structures between opposed cell membranes. A diagnosis of benign cephalic histiocytosis was made on the basis of these clinical, histological, immunohistochemical, and ultrastructural features.

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