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Erythema Toxicum Neonatorum
Chung-Dar Liao, Ren-Bin Tang, Ling-Yoeu Yang, I-Lin Shieh, Betau Hwang
Dermatol Sinica 9: 23-38, 1991

From July 1, 1989 to June 30, 1990, we collect 52 cases of erythema toxicum neonatorum from pediatric baby room at Taipei Veteran General Hospital. Twenty-eight cases are male and twenty-four female. The time of onset of skin rash after birth in our study are: <12hrs: 5.8%, 12-24hrs: 11.5%,24-48hsrs: 67.3%, and >48hrs: 15.4%. The total duration of skin lesion are 12-24hrs: 13.5%, 24-48hrs: 44.23%, 48-72hrs: 25% and>72hrs: 11.5%. There are no significant difference between incidence of erythema toxicum neonatorum and sex, nativity, birth season, meconium stain, the way of delivery, blood type , Hepatitis-B marker, milk-feeding, phototherapy and family history. The newborns of erythema toxicum neonatorum with atopic family history have more significant early onset and more longer duration of existence of existence of skin rash compared with those without atopic family history. The total eosinophil count (TEC) of maximal eruption after birth of both atopic group and nonatopic group babies show significant higher than that of normal babies group (p<0.001), and the TEC of initial onset and maximal eruption of skin rash after birth are significantly higher in babies of atopic group compared with those of nonatopic group (p<0.01 and p<0.001), while the eosinophil differential count (%) of initial onset and maximal eruption of skin rash after birth between two groups show no significant difference (p<0.05 and p<0.1). It seems that, TEC shows more correlation with clinical skin manifestation of babies than the eosinophil differential count(%). There are no significant change of IgE between both atopic and nonatopic groups. The elevation of TEC during skin rash onset and the Wright stain of the pustule skin lesion which show many eosinophil infiltration suggest that "Erythema Toxicum Neonatorum" is closely related to "Allergy".

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