Back issues No.4 - 1993 / Original Study  

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Dry Ice Cryotherapy for Nevus of Ota
Jau-Shiuh Chen, Chun-Hsiang Chang
Dermatol Sinica 11: 235-244, 1993

We use dry ice to treat 30 patients with nevus of Ota since 1987. Dry ice was applied to lesions with firm pressure for half a second to 4 seconds, once every 2 to 8 weeks (average 4 weeks). Total treatment duration ranged from 5 to 42 months. We found that better clinical responses were expected about 10 months after starting treatment. Excluding 8 cases considered inadequate duration of therapy (<10 months), 73% (16/22) of patients had more than 70% pigment clearing and 86% (19/22) of patients had more than 50% pigment removal. Transient hyper-and hypo-pigmentation occurred in 63% (19/30) and 23% (7/30) of patients, respectively. Seven cases complained of increased acne formation which could be controlled easily. Minimal texture changes were noticed in 3 cases. Comparing to the expense of Q-switched ruby laser for nevus of Ota, dry ice cryotherapy costs much less. In conclusion, dry ice cryotherapy is an economic and effective cosmetic treatment for nevus of Ota.

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