Back issues No.4 - 1993 / Case Report  
 
 

Full Text PDF

 

Albinism - A Case with Immunohistochemical Studies
Jin-Wha Kang, Chao-Hsing Kao, Chiung-Chun Pan, Ching-Jer Hsu, Tzu-Man Wu, Hsin-Su Yu
Dermatol Sinica 11: 277-285, 1993

A 47-year-old male was born with depigmentation of whole body, hair and eyes; and had a albinism family history. In recent two years, multiple crusted nodules developed on sun exposed area. Biopsies taken from above lesions revealed either carcinoma in situ or invasive squamous cell carcinoma (SCC). Besides, the SCC-free depigmented skin biopsy showed markedly actinic aging. The dopa reaction of hair bulb showed positive response. The serum level of tyrosine was normal. The melanocyte culture obtained from patient's skin revealed decreased cellular dopa reaction and tyrosinase activity. By direct immunofluorescence with Ks8.12 antibody, it revealed increased existance of keratin 16. A marked depletion of OKT6-positive epidermal Langerhans cells was noted.Considering the clinical expressions, histopathological and laboratory studies, this case was a typical tyrosinase positive oculocutaneous albinism presented with prominant photodamage and multiple skin cancers on sun exposure area.

   
   
 
 
You are visitors    
Copyright © 2008 THE Taiwanese Dermatological Association. All Rights Reserved. Email: dermatol.sinica@gmail.com Tel:886-2-2518-5126~7 Fax:886-2-2518-5128