Back issues No.3 - 1994 / Original Study  

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Extramammary Paget's Disease of Male External Genitalia - A Study of 16 Cases and Its Relationship to Extracutaneous Malignancy -
Chung-Ren Tseng, Jau-Shiuh Chen, Chun-An Hsu, Shyh-Dyi Chung, Shu-Ling Hu
Dermatol Sinica 12: 101-110, 1994

We collected 16 cases of patients with extramammary Paget's disease (EMPD) of male external genitalia during 1977 to 1992 from the Cancer Registry, Office of Medical Record, National Taiwan University Hospital. The age ranged from 59 to 84 years, with a mean of 66.9 years. Average duration between onset of disease and diagnosis is 4.4 years. Thirteen cases received surgical intervention, and three of them had local recurrence. Two other cases had lymph node metastasis; they received conservative treatment and radiotherapy, respectively. Both of them died within one year. The other one, having extensive involvement of perineal, perianal, scrotal areas and inner thighs, received topical topical treatment with 5-FU, and died 9 years after diagnosis. Except the 3 mortality and 2 lost follow-up cases, the remaining 11 cases received cancer servey, and no extracutaneous malignancy was found in all of them. All cases of EMPD of male external genitalia published in English literatures since 1962 and in one recently published Japanese paper, along with our own 11 cancer surveyed cases, were collected to study the relationship between EMPD of male external genitalia and extracutaneous malignancy. We suggest that, if EMPD of male external genitalia does not involve glans penis and perianal skin, and does not have lymph node metastasis, it is unlikely to find extracutaneous malignancy, therefore, cancer survey is unnecessary. On the contrary, if EMPD involves glans penis, it is highly possible to find another malignancy of genitourinary system, and further cancer survey of genitourinary system is indicated.

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