Back issues No.1 - 1995 / Case Report  

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Skin Carcinoma With Neuroendocrine Differentiation
Eric J. Gagne, W. P. Daniel Su, Mark R. Pittekow
Dermatol Sinica 13: 1-12, 1995

A rapidly growing tumor on the face of an 87-year-old woman was excised for histopathologic evaluation. The tumor consisted of a poorly differentiated carcinoma with unusual neuroendocrine differentiation. Focal and prominent immunoreactivity for neuron-specific enolase, synaptophysin, and chromogranin was among the distinctive features. Ultrastructural examination demonstrated neurosecretory granules. Additional morphologic findings included clusters of clear cell differentiation. These findings indicate that this peculiar malignant tumor is distinct from typical neuroendocrine carcinoma of skin (Merkel cell carcinoma). We believe that this tumor represents a unique cutaneous neoplasm with histologic potential for neuroendocrine differentiation. Its recognition broadens the concept of cutaneous neuroendocrine tumors.

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