Back issues No.1 - 1995 / Case Report  

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Clear Cell Squamous Cell Carcinoma
Chung-Wen Ko, Ching-Nan Lin
Dermatol Sinica 13: 33-39, 1995

A 72-year-old male developed a protruding, round-shaped, smooth, and erythematous nodule on the anterior chest wall of 18 months duration. Histopathological examination revealed lobules of 'clear' tumor cells and focal areas of keratinization; with special stains, these clear cells were negative with PAS and alcian blue staining, and oil red O staining on residual formalin-fixed wet tissue also failed to indicate any lipid deposition in the cytoplasm. Immunohistochemically, the tumor cells mostly showed positive reaction for cytokeratin, but did not express CEA or HMB-45. A diagnosis of clear cell squamous cell carcinoma was made on the basis of above histochemical and immunohistochemical features.

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