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Study on Cutaneous Physio-Immuno-Pathological Status in Tinea Pedis
Kan-Tang Fang, Shoh-Cheng Shih, Chung Hsing Chang, Ji-Chen Ho
Dermatol Sinica 13: 127-134, 1995

This study examined 10 cases of tinea pedis to assess the dermato-physiological, immunological and pathological status of lesion sites as compared to 10 normal control subjects. There was no significant change in involucrin, filaggrin or number of stratum corneum cell layers. A possible mechanism for these changes is that profuse sweat gland secretions predispose to alkalinization of skin which promotes fungal growth, and the decrease of sebum and amino acid of stratum corneum may attribute to that pathogens consuming amino acids and sebum as nutritions. Slight increase in IL-1 αlevels seen in infected areas could be due to a fungus-stimulated immune reaction in the stratum croneum.

   
   
 
 
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