Back issues No.3 - 1995 / Original Study  

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Retinoid Dermatitis Clinical Experience of Topical Tretinoin in 118 women-
Chen-Nai Wang, Heng-Leong Chan
Dermatol Sinica 13: 135-144, 1995

Since April 1993 to March 1994, we prospctedly collected the clinical data in consecutive 118 female who were treated with 0.05% tretinoin cream for acne, melasma or winkles. The cream was topically applied to face befored bed for 6 months. The range of age was from 24 years to 69 years. The overall incidence of retinoid dermatitis was 76% and the rate was reverted to the age. In most of the patients, retinoid dermatitis started within 2 weeks of treatment and persisted for 1 to 3 weeks and the severity was from mild to moderate. The symptoms of retinoid dermatitis included desquamation (77%), erythema(67%), itching (42%) and irritation (39%). Seven patients(6%) could not tolerate the reaction and discontinued the treatment. Another five patients (4%) got hyperpigmentation of face in the first month of treatment course and then the skin became paler in the end of the second month. In summary, well understanding the clinical picture of retinoid dermatitis could provide us the better application for patients' skin care.

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