Back issues No.3 - 1995 / Case Report  

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Cowdens Disease with Huge Hepatic Hemangioma
Te-Hsuan Li, Shyh-Dyi Chuang, Shiou-Hwa Jee, Bor-Luen Chiang
Dermatol Sinica 13: 187-196, 1995

Cowden's disease, or multiple harmatoma syndrome, a genodermatosis with an apparent autosomal dominant inheritance, is characterized by multiple harmatomatous neoplasms of ectodermal, endodermal and mesodermal origin. A 37-year-old man, presenting the characteristic features of Cowden's disease including cutaneous facial papules of trichilemmoma, acral keratosis, palmoplantar keratosis and multinodular goiter, is reported. The patient also had a huge hepatic hemangioma, a condition not previously mentioned in reports of Cowden's disease. The natural killer cell activity in the patient was decreasd. In the facial papules, no elements of human papillomavirus could be demonstrated by either the polymerase chain reaction or the immunostain with anti-papillomavirus antibody.

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