Back issues No.4 - 1995 / Original Study  

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Low-dose Cyclosporin A in Psoriasis
Tien-Yi Tzung, J. Yu-Yun Lee
Dermatol Sinica 13: 197-204, 1995

A total of 11 patients with severe psoriasis, including 8 plaque type and 3 erythrodermic type, with a baseline of psoriasis area and severe index (PASI) of at least 15 were treated with low-dose cyclosporin A (CysA) ranging from 3 to 4.5 mg/kg/day for 16 weeks. The treatment was classified as "successful" if the PASI was reduced to 25% or less of the baselinee value or below 8. Six of the patients having<50% reduction of PASI at weeks 6 were regarded as "non-responders" and CysA treatment was discontinued in 2 of them.Successful treatment was achieved in 5 patients, all of plaque type. The successful rate was 63% in the plaque type psoriasis. The result was comparable to other series. Relapse occurred during dose tapering in 4 patients. Rebound phenomenon with pustulation was noted in 1 patient after 1 week of interruption of CysA due to elevated liver function tests. Adverse events observed included hypertension, gingival hyperplasia, and hyperbilirubinemia. Questionnaires regarding patients' satisfaction of various systemic treatments received for psoriasis including UVB, methotrexate, etretinate, and CysA showed that the patients were more satisfied with CysA treatment.

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