Back issues No.4 - 1995 / Case Report  

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von Recklinghausens Disease Associated with Neurofibrosarcoma
Yih-Shun Chen, Yong-Chai Lee, Su-Tzu Huang, Kuo-Chia Yang, Kun-Tu Yeh
Dermatol Sinica 13: 257-263, 1995

This 25-year-old male patient had presented with typical cutaneous features of von Recklinghausen's disease for more than ten years. Rcently, he noted a new skin lesion over left infra-scapular area, which had clinical characteristics of more rapid growth, deeper situation, larger size and harder consistency in comparison with other neurofibromas. Histopathologic examination revealed neurofibrosarcoma with chondroid and osseous metaplasia. Sarcomatous change within a neurofibroma is not common. But it is a key point of ling term follow-up for patients with von Recklinghausen's disase.

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