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Factor X IIIa and CD34 in the Differential Diagnosis of Dermatofibroma and Dermatofibrosarcoma Protuberans
Hsiu-Chin Chen, Bee-Fan Chen, Jeng-Jer Chen, Hsin-Yi Su
Dermatol Sinica 14: 15-21, 1996

We use anti-Factor XIIIa and anti-CD34 antibodies for the differential diagnosis for dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP). We stained 24 DFs and 24 DFSPs. 21 DFs (87.5%) contained>10% Factor XIIIa reactive tumor cells. In DFSP, most cases (>90%) had no reactive tumor cells. Human progenitor cell antigen (CD34) was found in 22 DFSPs (>90%) that had>10% reactive tumor cells. In DF, the reactivity of most cases for CD34 was negative (75%) , and only 6 cases had<10% positive reactive tumor cells. When used together with other histopathological criteria, FXIIIa and CD34 antibodies can be extremely useful markers in differentiating between DF and DFSP.

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