Back issues No.2 - 1996 / Case Report  

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Madelungs Disease
Jiunn-Yih Chen, Sheau-Chiou Chao, J. Yu-Yun Lee
Dermatol Sinica 14: 89-94, 1996

Madelung's disease (benign symmetric lipomatosis) is a rare disease of undetermined cause charactrized by symmetric diffuse deposits of adipose tissue around the neck, suboccipital region, proximal extremities, and upper trunk. This disease usually affects middle-aged, non-obese alcoholic men.A 59-year-old man with a history of alcoholism and alcoholic liver disease noticed progressive enlargement of the arms and upper trunk in the past 2 months. Physical examination showed symmetric, diffuse, non-tender, lipomatous lesions involving the upper trunk and upper arms. Laboratory data were significant for hyperuricemia. Histopathology of the lipomatous tissue revealed prominent subcutaneous tissue consisting of small but mature adipocytes. The clinicopathological features were typical for Madelung's disease. The pathogenesis of the disease is discussed.

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