Back issues No.2 - 1996 / Case Report  

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Transfusion-Associated Graft-versus-host Disease
Yu-Chang Chan, Yuh-Chiau Chiang, Chi-Cheng Lin, Ren-Feng Lee, Hsu-Po Yeh
Dermatol Sinica 14: 100-106, 1996

Transfusion-associated graft-versus-host disease (TA-GVHD) is a hazardous, often fatal complication to the transfusion of blood components. It often occurs in immunocompromised patients and those who have received blood from related donors. The clinical features of TA-GVHD are characterized by skin rash, diarrhea, hepatic dysfunction and severe bone marrow suppression often during the first two weeks after transfusion. Here we report a case of a full-term female neonate, who developed TA-GVHD after blood exchange transfusion for neonatal hyperbilirubinemia with 500 ml of fresh whole blood from her father. We'd like to call attention to this severe complication of blood transfusion. Besides, we will review the literature and discuss the pathogenesis, risk factors and preventive methods.

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