Back issues No.2 - 1996 / Case Report  

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Linear IgA Disease Associated with Pregnancy
Chih-Tsao Chen, Jauh-Jhy Hurng, Tsu-Chyang Chen
Dermatol Sinica 14: 107-112, 1996

A healthy 30-year-old G2P1 female was admitted in the fourth month of pregnancy with pruritic bullous eruption on the back of one month's duration. Skin biopsy showed a subepidermal blister with infiltration of neutrophils and lymphocytes in the surrounding dermal papillae. Direct immunofluorescent study of perilesional skin on the back revealed linear deposition of IgA along the dermo-epidermal junction. Indirect immunofluorescent study detected binding of IgA to the epidermal aspect of 1M NaCl-split skin. Monoclonal antibodies of IgA1 and IgA2 were performed and revealed only deposition of IgA1 along the dermo-epidermal junction. The patient was treated with topical 0.1% amcinonide cream and significant improvement was noted within one month. She delivered a healthy baby at term without any skin lesions noted. Her skin lesions got remission six months postpartum.

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