Back issues No.2 - 1997 / Case Report  

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Scleromyxedema: Response to Isotretinoin
Chin-Lung Yang, Ji-Chen Ho, Yu-Wen Cheng
Dermatol Sinica 15: 115-120, 1997

Scleromyxedema, a variant of lichen myxedematosus, is a rare and chronic scleroderma-like cutaneous disorder. Benign monoclonal gammopathy was present in most patient. Frequently, it was associated with extracutaneous manifestation. Treatments usually were unsatisfactory. Herein waxy xolescent papules and thicked indurated plaques or nodules oer bony prominences for more than 3 years. The eruptions worsen in recent one year. Histopathology of the skin with special stains showed large accumulation of acid mucopolysaccharide in dermis both in papule and plaque lesions. Other findings included polyclonal IgG gammopathy, mild myopathy and vocal cord swelling. Obvious effacement of papules and some nodules were observed after 5 months' treatment with isotretinoin (30-50 mg/day). Because of the favorable response to isotretionin in our patient and several other patients in the literature, isotretionin can be recommended as a choice of treatment for scleromyxedema.

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