Back issues No.3 - 1997 / Case Report  

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Cutaneous Rosai-Dorfman Disease: Report of a Case Treated with Isotretinoin
Ya-Huey Chuang, Heng-Leong Chan, Tseng-Tong Kuo
Dermatol Sinica 15: 186-193, 1997

We report a case of Rosai-Dorfman disease (RDD) confined to the skin. The patient was a 55-year-old woman, she presented with a history of gradual onset of multiple, nonternder, indurated plaques, and firm, subcutaneous nodules during 2 year-period. No fever, weight loss, or night sweating was experienced. Skin biopsy revealed a dense, nodular, dermal infiltrate composed of large histiocytes admixing with plasma cells, lymphocytes, and neutrophils and occasional emperipolesis. The diagnosis was further confirmed by positive immunoreactivity of the large histiocytes to S-100 protein. Physical examination, chest roentgenography, and computed tomographic scan of her abdomen showed no evidence of lymph node involvement. She was treated with isotretinoin (10 mg three times a day) and the skin lesions improved rapidly within 2 weeks. The therapy was continued for 2 months and no new skin kesions developed over a 6-month follow-up period.

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