Back issues No.3 - 1997 / Case Report  

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Primary Cutaneous Rosai-Dorfman Disease
Chin-Lung Yang, Hsuan-Ying Huang, Ji-Chen Ho, Wei-Jen Chen
Dermatol Sinica 15: 194-199, 1997

Rosai-Dorfman disease (RDD)(Sinus histocytosis with massive lymphadenopathy) is a systemic proliferation of cells that resemble the sinus histiocytes of lymph nodes. Cutaneous lesions are usually associated with nodal or other extranodal location. We herein describe a female with RDD clinically limited to the skin. The patient presented with asymptomatic dermal nodules on the abdominal wall. Histologically, the lesion consisted of a proliferation of large histiocytes cytoplasmic positivity in the histiocytes. No other foci could be detected by thorough physical examination. Primary cutaneous Rosai-Dorfman disease is rarely reported in the literature.

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